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Advil Day/Night Convenience Pack: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Over-the-counter (OTC) Current status: Cancelled Post Market
Strength:
200 mg / 200 mg / 25 mg
Active ingredients:
ATC code:
Similar drugs:

Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - Advil Day/Night Convenience Pack

ABOUT THIS MEDICATION

Advil Liqui-Gels (Daytime)

Temporary relief of mild to moderate migraine headaches including associated symptoms of nausea, and sensitivity to light and sound.

Fast and effective temporary relief of muscle aches and pain, joint and body pain, backache, muscle sprains and strains, pain of inflammation associated with conditions including arthritis and physical or athletic overexertion (e.g. sprains or strains), headache including tension headache, dental pain and menstrual pain.

Advil Nighttime

For fast and effective temporary relief of occasional mild to moderate nighttime pain and accompanying sleeplessness, due to minor aches and pains associated with joints, muscles, backache, headache and toothache as well as pain of migraine and arthritis.

For longer sleep, uninterrupted by temporary pain.

Only for temporary mild to moderate pain that causes sleeplessness. If this is not the case, do not use.

What it does:

Contains: ibuprofen (a pain reliever for short term use). Advil Nighttime contains one extra ingredient, diphenhydramine hydrochloride (a sleep-aid for sleeplessness). Pain relief from ibuprofen helps to fall asleep, and diphenhydramine helps to stay asleep.

When it should not be used:

Do not use if you have/are:

  • allergic/hypersensitive to ibuprofen or other non-steroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA) or other salicylates, diphenhydramine or to any ingredient in the formulation or component of the container, or any of Advil Nighttime ingredients (Refer to

    • the nonmedicinal ingredients on outer carton or composition section)
    • active peptic ulcer, or recurrent stomach ulcer, gastrointestinal (GI) bleeding or active inflammatory bowel disease (e.g. Crohn’s, colitis)..
    • Nasal polyps (swelling of the inside of the nose), or allergic manifestations such as asthma, anaphylaxis (sudden severe life threatening allergic reaction), uticaria/hives, rhinitis (stuffed or runny nose that may be due to allergies), skin rash or other allergic symptoms,
    • Taking ASA, acetaminophen, or other NSAIDs, such as naproxen or other ibuprofen product.
    • dehydrated (significant fluid loss) due to vomiting, diarrhea or lack of fluid intake
    • heart problems, such as high blood pressure or severe coronary artery disease,
    • Right before or after heart surgery.
    • serious liver or kidney disease,
    • high potassium in the blood,
    • Systemic Lupus Erythematosus

    • In your third trimester of pregnancy

Do not use Advil Nighttime if you have/are:

  • Pain that does not keep you from sleeping.
  • Sleeplessness but are not in pain.
  • Taking antihistamines and or diphenhydramine containing products, (e.g. for cough & cold, sleep aids, etc.), monoamine oxidase inhibitors (MAOIs)

What the medicinal ingredients are:

Advil Liqui-Gels: Ibuprofen (present as free acid and potassium salt)

Advil Nighttime: Ibuprofen (present as free acid and potassium salt) and diphenhydramine hydrochloride.

What the nonmedicinal ingredients are:

Advil Liqui-Gels: FD&C green no. 3, gelatin, lecithin (soy), medium chain triglycerides, pharmaceutical ink, polyethylene glycol, potassium hydroxide, purified water, sorbitan, sorbitol.

Advil Nighttime: Coconut oil, D&C red no. 33, FD&C blue no. 1, gelatin, pharmaceutical ink, polyethylene glycol, potassium hydroxide, purified water, sorbitan, and sorbitol.

What dosage forms it comes in:

Advil Liqui-Gels: Each liquid filled capsule contains ibuprofen 200 mg (present as free acid and potassium salt).

Advil Nighttime: Each Liqui-Gel (gelatin capsule) contains ibuprofen 200 mg (as free acid and potassium salt) and diphenhydramine hydrochloride 25 mg.

WARNINGS AND PRECAUTIONS

Serious Warnings and Precautions

  • Caution in patients prone to gastrointestinal tract irritation, including those with a history of peptic ulcer. The chance of stomach bleeding is higher if you are: age 60 or older, have had stomach ulcers or bleeding problems, take a blood thinner or steroid drug, take with other drugs containing an NSAID ASA, ibuprofen, naproxen, or prescription anti-inflammatory drugs, have 3 or more alcoholic drinks every day while using this product.
  • Patients at risk of kidney problems, including the elderly or those using diuretics.
  • Use during pregnancy or nursing should be avoided.
  • Stop use immediately if you have difficulty or pain when urinating.
  • Advil Nighttime causes sedation or sleepiness. Not for daytime use.

BEFORE use, talk to your doctor or pharmacist if you have/are:

  • previous or current stomach ulcers, diabetes, thyroid disease, mild to moderate kidney disease, mild to moderate liver disease, heart disease, glaucoma, breathing problems or chronic lung disease (such as asthma, emphysema or chronic bronchitis), blood clotting disorder (such as hemophilia), difficulty in urination due to prostate enlargement or bladder neck obstruction, any other serious condition, are taking any other prescription or over-the-counter drug, including any other anti-inflammatory medication
  • Autoimmune disease (e.g., lupus)
  • High blood pressure
  • Over 65 years of age
  • You are trying to conceive, in your first or second trimester of pregnancy or if you are breastfeeding
  • Sleeplessness due to mild to moderate pain persists continually for more than 5 days.

Insomnia may be a symptom of a serious underlying medical condition other than pain.

While taking Advil Nighttime, do not drive motor vehicle or operate machinery.

Use with caution in the elderly

Long-term continuous use may increase the risk of heart attack or stroke.

Stop use and ask a doctor if

•you show signs of stomach bleeding

•pain worsens or lasts more than 5 days

•fever worsens or lasts more than 3 days

•any new symptoms appear

INTERACTIONS WITH THIS MEDICATION

Do not use Advil Liqui-Gels or Advil Nighttime if you are taking:

  • Daily low dose ASA (81 – 325 mg), without talking to a doctor or pharmacist. Ibuprofen may interfere with the preventive benefits of ASA.

Drugs that may interact with Advil Liqui-Gels or Advil Nighttime include:

Acetaminophen, anticoagulants (blood thinners), apomorphine, alcohol, digoxin, antidiabetic agents (oral) and insulin, diuretics, methotrexate, lithium, probenecid, thyroxine, antibiotics (e.g. cyclosporine), phenytoin, corticosteroids, benzodiazepines, blood pressure medications, depression medications, monoamine oxidase inhibitors (MAOIs), antihistamines (such as allergy medications), tranquilizers, alcohol or other sedating drugs, NSAIDs (including naproxen and ibuprofen), sleep-aids, cold medications

Tell your doctor or pharmacist what prescription drugs you are taking or plan to take.

PROPER USE OF THIS MEDICATION

Usual dose:

Adults and children 16 to 65 years of age: Advil Liqui-Gels (Daytime): Take 1 green Liqui-Gel every 4 hours or 2 green Liqui-Gels every 6-8 hours at the first sign of symptoms as needed. Advil Nighttime : Take 1 or 2 blue Liqui-Gels at night, 4-6 hours after the last daytime ibuprofen or diphenhydramine dose. Do not take for more than 5 consecutive days/nights unless directed by a doctor. Do not exceed a combined total of any 6 Advil Liqui-Gels or Advil Nighttime Liqui-Gels in 24 hours, unless directed by a doctor.

Do not give to children under 16 unless directed by a doctor .

Do not use longer than 3 days for a fever or 5 days for pain or cold symptoms.

Overdose:

In case of accidental overdose: stop use and contact a Poison Control Centre,doctor, healthcare practitioner, hospital emergency department immediately, even if there are no symptoms.

Missed Dose:

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take your medicine and skip the missed dose. Do not take twice the recommended dose after a missed dose.

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

Take with food or milk if upset stomach occurs.

If abdominal pain, heartburn, nausea or vomiting, bloating, diarrhea or constipation, ringing or buzzing in the ears, nervousness, sleeplessness, dizziness, any change in vision, fluid retention, shortness of breath, wheezing, any trouble breathing or chest tightness, hives, swelling oritching, skin rashes, skin reddening, blisters, blood in vomit, bloody or black stools, jaundice (yellowing of the eyes or skin due to liver problem), or any other side effect or unexplained symptoms develop while taking Advil Nighttime discontinue use immediately and contact a physician.

Consult your physician if the symptoms of pain or sleeplessness persist for more than 5 days.

Side effects may be minimized by using the smallest dose for the shortest duration of time.

SERIOUS SIDE EFFECTS, HOW OFTEN THEY HAPPEN AND WHAT TO DO ABOUT THEM
STOP USE and consult your doctor immediately if you experience: abdominal pain, allergic reaction (itching, blisters, rashes, skin reddening, etc), any change in vision, blood in vomit, bloody or black stools, bladder pain, hallucinations, or difficulty speaking.

This is not a complete list of side effects. For any unexpected effects while taking Advil Liqui-Gels or Advil Nighttime, contact your doctor or pharmacist.

HOW TO STORE IT

Store at room temperature (15°-30°C).

Keep out of reach of children. This package contains enough medicine to seriously harm a child.

MORE INFORMATION

This document plus the full product monograph, prepared for health professionals can be found by contacting the sponsor, GlaxoSmithKline Consumer Healthcare Inc., Mississauga, ON L5N 6L4 at: 1-888-275-9938 or www.advil .ca.

This leaflet was prepared GlaxoSmithKline Consumer Healthcare Inc.

Product monograph available to doctors and pharmacists upon request.

Last revised: November 4, 2020

REPORTING SUSPECTED SIDE EFFECTS

You can report any suspected adverse reactions associated with the use of health products to the Canada Vigilance Program by one of the following 3 ways:

Report online at www.healthcanada.gc.ca/medeffect

  • $ Call toll-free at 1-866-234-2345

  • $ Complete a Canada Vigilance Reporting Form and:

    • Fax toll-free to 1-866-678-6789, or

    • Mail to: Canada Vigilance Program

      Health Canada

      Postal Locator 0701E

      Ottawa, ON K1A0K9

Postage paid labels, Canada Vigilance Reporting Form and the adverse reaction reporting guidelines are available on the MedEffect™ Canada Web site at www.healthcanada.gc.ca/medeffect.

NOTE: Should you require information related to the management of side effects, contact your health professional. The Canada Vigilance Program does not provide medical advice.

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02410583

Revision date stated in the text: November 4, 2020

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Advil Day/Night Convenience Pack

Rx or OTC
Over-the-counter (OTC)?
DIN 02410583
Schedule(s) NON-PRESCRIPTION DRUGS
Active ingredient(s) Ibuprofen 200 MG, Diphenhydramine hydrochloride 25 MG
Dosage form(s) Kit, Capsule
Route(s) of administration Oral
Drug class (WHO ATC)
  1. M Musculo-skeletal system drugs
    1. M01 Antiinflammatory and antirheumatic products
      1. M01A Antiinflammatory and antirheumatic products, non-steroids
        1. M01AE Propionic acid derivatives, antiinflammatory and antirheumatic products
          1. M01AE51 Ibuprofen, combinations
Company GLAXOSMITHKLINE CONSUMER HEALTHCARE ULC
Current status Cancelled Post Market
Current status date November 7, 2023

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.