Auro-Liothyronine: Uses, Side Effects and Dosage

ABOUT THIS MEDICATION

What the medication is used for

Auro-Liothyronine (liothyronine sodium) is used for the treatment of:

• Mild to severe hypothyroidism (thyroid gland does

  not produce enough hormone);

• Enlarged thyroid gland (simple goiter)

What it does

Auro-Liothyronine (liothyronine sodium) is a synthetic form of a hormone produced by the thyroid gland called triiodothyronine.

When it should not be used

Auro-Liothyronine should not be used if you have:

• a hypersensitivity or allergy to thyroid hormones

  (liothyronine sodium) or to any nonmedicinal ingredients in Auro-Liothyronine;

• uncorrected adrenal gland under-activity;
• acute myocardial infarction (heart attack)

What the medicinal ingredient is

Liothyronine sodium

What the non medicinal ingredients are

Calcium Sulfate, Corn Starch, Gelatin, Magnesium Stearate, Mannitol.

What dosage form it comes in

Auro-Liothyronine is available as round, white to off-white tablets.

The tablets are available in two strengths: 5 micrograms and 25 micrograms. The 5 mcg tablets are white to off white, round, biconvex tablets debossed with “LT” one side of the tablet and “5” on other side. The 25 mcg tablets are white to off white, round biconvex tablets debossed with “LT25” one side of tablet and break line on other side.

WARNINGS AND PRECAUTIONS

Serious Warnings and Precautions

Auro-Liothyronine, like other thyroid hormones, should not be used for the treatment of obesity or for weight loss, either alone or with other medicines. At normal doses, Auro-Liothyronine does not reduce body weight and at higher doses, it can produce serious or even life-threatening side effects.

BEFORE or WHILE YOU USE Auro-Liothyronine, talk to your doctor if you have the following condition:

• any heart problems, such as a heart attack, angina pectoris (chest pain)
• a history problem with thyroid (myxedema), or adrenal or pituitary gland
• kidney disease
• high blood sugar (diabetes)

• decreased development of sexual organs

  (hypogonadism)

• bone thinning (osteoporosis)

• pregnant or planning to become pregnant

• breast feeding
• blood clotting problem

INTERACTIONS WITH THIS MEDICATION

Before or while you use Auro-Liothyronine tell your doctor or pharmacist about all other medications you take including medications that you bought without a prescription, vitamins, and natural products. Particularly if you are taking the following:

• Blood thinner (anticoagulants)
• Medications for high cholesterol levels such as lovastatin, cholestyramine, clofibarate
• Medications for high blood sugar or insulin
• Medications that contain estrogen such as birth control pills
• Amiodarone
• Medicines that contain iodine such as radiographic contrast agents
• Heroin/methadone
• 5-fluorouracil, mitotane, tamoxifen
• Tricyclic antidepressant such as imipramine
• Digoxin (digitalis)
• Cyokines such as interferon-alpha, interleukin-2
• Growth hormones
• Ketamine
• Theophylline
• Diazepam
• Ethionamide
• Metoclopramide
• Perphanazine
• Resorcinol (topical products)
• Para-aminosalicylate sodium

Some medicines may interfere with blood tests done to determine thyroid hormone levels (thyroid function tests). It is important to inform your doctor of all medicines you are taking before and at the time of blood tests.

The following drugs are known to interfere with laboratory tests performed in patients on thyroid hormone therapy:

• Androgens (male hormones)
• Corticosteroids (eg., prednisone, dexamethasone)
• Estrogens and estrogen-containing oral contraceptives (birth control pills)
• Preparations containing iodine
• Salicylates (eg., aspirin)

PROPER USE OF THIS MEDICATION

You should take Auro-Liothyronine as prescribed by your doctor. Treatment is usually started with a low dose of Auro-Liothyronine, then increased gradually according to your response. OPER USE OF

Overdose

Missed dose

If you miss a dose, take it as soon as you remember on the same day. Skip that dose if you do not remember until the next day.

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

Side effects with Auro-Liothyronine may include symptoms of hyperthyroidism as follows: Headache, excessive sweating, fatigue, increased appetite, weight loss, fever, nervousness, anxiety, irritability, insomnia, cardiac arrhythmias (heartbeats which are irregular or too fast), angina pectoris (chest pain), diarrhea and menstrual irregularities.

Tell your doctor about any other side effect that is not included above or if you have any question. Your doctor may ask you stop taking Auro-Liothyronine until the symptoms disappear, and re-start after one or two days at a lower dose.

HOW TO STORE IT

Store between 15^o and 30^o C (59^o and 86^oF)

The product should be stored in the original container.

Keep away from light and moisture.

Keep container firmly closed and away from the reach and sight of children.

Reporting Side Effects

MORE INFORMATION

• Talk to your healthcare professional

• Find the full Product Monograph that is prepared for healthcare professionals and includes this Consumer Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s Website http://www.auropharma.ca, or by calling

  1-855-648-6681.

Last revised: JUL 17, 2024