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Fluconazole Injection (Fresenius Kabi Canada): Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx) Current status: Cancelled Pre Market
Strength:
2 mg
Active ingredient:
ATC code:
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Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - Fluconazole Injection (Fresenius Kabi Canada)

ABOUT THIS MEDICATION

What the medication is used for:

Fluconazole Injection is one of a group of medicines called antifungals.

Fluconazole Injection is prescribed by your doctor and is used to treat infections caused by fungi including yeasts and may also be used to stop you from getting a fungal infection. The most common cause of fungal infection is a yeast called Candida.

What it does:

Fluconazole Injection selectively interferes with the normal sterol production in fungi and helps to stop fungal growth.

When it should not be used:

Do not take Fluconazole Injection if you have ever had an allergic reaction to:

  • any of the ingredients of Fluconazole Injection (see What the nonmedicinal ingredients are)
  • other medicines you have taken to treat a fungal infection.

The symptoms may include itching, reddening of the skin or difficulty in breathing.

Do not take Fluconazole Injection if you are taking any of the following drugs:

  • Erythromycin (an antibiotic for treating infections),
  • Pimozide (for treating schizophrenia) and
  • Quinidine (used for irregular heartbeats).

What the medicinal ingredient is:

fluconazole

What the important non-medicinal ingredients are:

sodium chloride

What dosage forms it comes in:

Fluconazole Injection is available as a sterile aqueous solution for direct infusion.

WARNINGS AND PRECAUTIONS

BEFORE you use Fluconazole Injection talk to your doctor or pharmacist if you:

  • have liver or kidney problems
  • are allergic to any other medicines including those used to treat yeast and other fungal infections
  • have abnormal levels of potassium, calcium or magnesium in your blood

  • are breast-feeding or planning to breast-feed. Fluconazole Injection is excreted in human breast milk. Breast-feeding is not recommended.

  • have heart disease such as heart conditions, blood disorders or any other medical conditions.

  • are driving and using machines. It should be taken into account that occasionally dizziness or seizures may occur.

  • are taking or have taken any other medicines, including medicines obtained without a prescription

  • Use in Children

    Your doctor will decide whether this medication is suitable for your child.

  • Use in Pregnancy

    • Fluconazole may cause permanent harm to your unborn baby and may cause a miscarriage of your pregnancy.
    • If you are pregnant or planning to become pregnant, talk to your doctor.
    • Fluconazole should not be used in pregnancy except in severe or life-threatening infection.
    • Your doctor will decide if Fluconazole should be used in your situation.

If you are a woman of child-bearing potential then:

  • Avoid becoming pregnant during treatment
  • Use effective contraception during
  • treatment and for 1 week after treatment
  • Tell your doctor if you become pregnant during treatment

INTERACTIONS WITH THIS MEDICATION

Drugs that may interact with Fluconazole Injection include:

  • Alfentanil, fentanyl or methadone (used to treat pain);
  • Amiodarone (used for irregular heartbeats)
  • Amitriptyline, nortriptyline (used to treat migraine and other conditions);
  • Amphotericin B and Voriconazole (used to treat fungal infections);
  • Benzodiazepines such as midazolam, triazolam, or similar medicines (used to help you sleep or for anxiety);
  • Calcium channel blockers or losartan (for lowering blood pressure);
  • Carbamazepine or phenytoin (used to control epilepsy);
  • Celecoxib (used to treat some types of arthritis and certain other types of pain);
  • Cimetidine (for heartburn and peptic ulcers);
  • Coumarin-Type or Indanedione Anticoagulants§ (used to thin the blood to prevent blood clots);
  • Cyclophosphamide, or vinca alkaloids (for treating some forms of cancer);
  • Cyclosporine, sirolimus or tacrolimus (to prevent transplant rejection);
  • Halofantrine (to treat malaria);
  • HMG-CoA reductase inhibitors (statins) (for lowering cholesterol);
  • Ibrutinib (for treating some forms of cancer)

  • Medicines for treating infections (antibiotics)

    such as azithromycin, erythromycin, rifampin or rifabutin;

  • Non-steroidal anti-inflammatory drugs (such as acetylsalicylic acid and ibuprofen) that are used to treat pain and fever;
  • Olaparib (for treating some forms of cancer);
  • Oral Contraceptives;
  • Prednisone (used to treat many types of inflammatory and allergic conditions);
  • Saquinavir or zidovudine, also known as AZT (used in HIV-infected patients);
  • Sulfonylureas and other Oral Hypoglycemics

(medicines for diabetes);

  • Theophylline (used to control asthma);
  • Tofacitinib (used to treat rheumatoid arthritis);

  • Tolvaptan (used to treat some type of kidney

    disease)

  • Vitamin A (as a trans-retinoid acid used to treat acne);
  • Water tablets (diuretics), such as hydrochlorothiazide, (used to treat fluid retention and high blood pressure).

§Indanedione Anticoagulants not commercially available in Canada

PROPER USE OF THIS MEDICATION

Usual dose:

Take Fluconazole Injection only as directed by your doctor.

Overdose:

If you think you have taken too much Fluconazole Injection, contact your health care professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.
  • •

Missed Dose:

If a dose of this medication has been missed, it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do not double dose.

  • •

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

  • •
  • Like all medicines, Fluconazole Injection may cause some side effects.

  • The most common side effects are:

    • Headache,
    • Skin rash,
    • Abdominal pain,
    • Diarrhea,
    • Nausea and vomiting.
SERIOUS SIDE EFFECTS, HOW OFTEN THEY HAPPEN AND WHAT TO DO ABOUT THEM
Symptom / effectTalk with your doctor or pharmacistStop taking drug and get immediate medical help
Only if severeIn all cases

Exfoliative skin disorders: Severe skin reactions, such as a rash that causes blistering, itching all over the body, reddening of the

skin or itchy red spots, swelling of eyelids, face or lips, peeling or lost skin

√

Hepatic necrosis (death of liver cells which may cause abdominal pain and dark urine, fever, light-colored stool, and jaundice (a yellow appearance to the skin and

white portion of the eyes))

√
Heart conditions: Unstable or irregular heartbeat (e.g. QT prolongation, torsade de pointes)√
Allergic Reaction with symptom such as swelling of the face, throat, mouth, extremities, difficulty in breathing, rash or itching√

This is not a complete list of side effects. For any unexpected effects while taking Fluconazole Injection, contact your doctor or pharmacist immediately.

HOW TO STORE IT

Store at 15 oC to 30 oC. Do not freeze.

Keep out of reach and sight of children.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

MORE INFORMATION

If you want more information about Fluconazole Injection:

  • Talk to your healthcare professional
  • Find the full Product Monograph that is prepared for healthcare professionals and includes this Consumer Information by visiting the Health Canada website (https://health-products.canada.ca/dpd-bdpp/index-eng.jsp); the manufacturer's website (https://www.fresenius-kabi.ca), or by calling 1-877-821-7724.

Fresenius Kabi Canada Ltd.

165 Galaxy Blvd, Suite 100

Toronto, ON M9W 0C8

Last Revised: January 7, 2021

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02248731

Revision date stated in the text: January 7, 2021

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Fluconazole Injection (Fresenius Kabi Canada)

Rx or OTC
Prescription (Rx)?
DIN 02248731
Schedule(s) PRESCRIPTION
Active ingredient(s) Fluconazole 2 MG
Dosage form(s) Solution
Route(s) of administration Intravenous
Drug class (WHO ATC)
  1. J Antiinfectives for systemic use
    1. J02 Antimycotics for systemic use
      1. J02A Antimycotics for systemic use
        1. J02AC Triazole derivatives, systemic antimycotics
          1. J02AC01 Fluconazole
Company FRESENIUS KABI CANADA LTD
Current status Cancelled Pre Market
Current status date June 28, 2021

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.