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Fosaprepitant for Injection: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
150 mg
Active ingredient:

Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - Fosaprepitant for Injection

ABOUT THIS MEDICATION

What the medication is used for:

Fosaprepitant for Injection, in combination with 5-HT3 antagonists and dexamethasone, is indicated for the prevention of nausea and vomiting associated with your cancer chemotherapy treatment.

What it does:

Fosaprepitant for Injection is a member of a class of medicines called neurokinin 1 (NK1) receptor antagonists. Fosaprepitant when administered intravenously is rapidly converted to aprepitant. Aprepitant works by blocking neurokinin, a substance in the brain that causes nausea and vomiting.

When it should not be used:

Do not take Fosaprepitant for Injection if you are allergic to fosaprepitant dimeglumine, aprepitant or any of the other ingredients of Fosaprepitant for Injection.

Do not take Fosaprepitant for Injection with pimozide, terfenadine, astemizole, or cisapride. Taking Fosaprepitant for Injection with these medications could result in serious or life-threatening problems.

What the medicinal ingredient is:

Fosaprepitant dimeglumine

What the important non-medicinal ingredients are: Lactose monohydrate, polysorbate 80, edetate disodium, sodium hydroxide and/or hydrochloric acid (for pH adjustment), water for injection.

What dosage forms it comes in:

Powder for injection. Each vial contains 150 mg of fosaprepitant.

WARNINGS AND PRECAUTIONS

Serious Warnings and Precautions

Drug interactions may occur with:

  • Medicines that are likely to be broken down mainly by the liver. This may increase the levels of the medication in your blood.
  • Warfarin. It may affect your blood test results.
  • Hormonal contraception (birth control medicines). It may reduce the effectiveness of the birth control you are taking. Discuss with your physician regarding use of an alternate or backup method of birth control during and for 1 month after the last dose of Fosaprepitant for Injection.

Possible serious side effects:

  • Severe allergic (hypersensitivity) reactions during or soon after infusion. Signs include swelling (face, eyes, lips, tongue, throat and skin), rash, itching, redness of the face and skin, difficulty in breathing and swallowing, and serious drop in blood pressure.

BEFORE you use Fosaprepitant for Injection talk to your physician or pharmacist if you:

  • have any past or present medical problems
  • have liver problems
  • have any allergies

  • drive a car or operate machinery

  • are pregnant or plan to become pregnant

  • are breast-feeding or plan to breast-feed

Use in children

Fosaprepitant for Injection should not be given to children under 18 years of age.

Use in the elderly

No dosage adjustment is necessary.

INTERACTIONS WITH THIS MEDICATION

Tell your physician about all medicines that you are taking or plan to take, even those you can get without a prescription or herbal products.

IMPORTANT: PLEASE READ

Your physician may check that your medicines are working properly together if you are taking other medicines such as:

  • anti-anxiety drugs (such as alprazolam, midazolam)
  • birth control medicines (which may not work as well)
  • ketoconazole (an antifungal)
  • rifampin (an antibiotic)
  • paroxetine (a medicine used to treat a certain type of depression)
  • diltiazem (a medicine used to treat high blood pressure)
  • dexamethasone, methylprednisolone (steroid medicines used for a variety of conditions)
  • warfarin (a blood thinner)
  • tolbutamide (a medicine used to treat diabetes)
  • phenytoin (a medicine used to treat seizures)
  • some chemotherapy medications such as ifosfamide

PROPER USE OF THIS MEDICATION

Fosaprepitant for Injection may be taken with or without food.

Usual dose:

Fosaprepitant for Injection 150 mg given on Day 1 only.

  • Day of chemotherapy: Fosaprepitant for Injection 150 mg will be given to you intravenously approximately 30 minutes before you start your chemotherapy treatment.

Overdose:

If you think you, or a person you are caring for, have taken too much Fosaprepitant for Injection, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms.

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

Like all prescription drugs, Fosaprepitant for Injection may cause side effects. Just because side effects have occurred in other patients does not mean you will get them. If you experience any side effects that bother you, please contact your doctor or pharmacist.

Side effects include:

  • low white blood cell counts
  • diarrhea
  • stomach pain
  • constipation

  • upset stomach

    • nausea
    • vomiting
    • fatigue
    • dizziness
    • weakness
    • loss of appetite
    • joint pain
    • taste disturbance
    • headache
    • urinary tract infection
    • dehydration
    • pain and/or tingling in the limbs
    • anxiety
    • nose bleeds
    • hiccups
    • low red blood cell counts
    • chest pain
    • shortness of breath
    • sores in the mouth

Infusion site reactions (ISR) at or near the infusion site have happened with fosaprepitant.

Most severe ISR have happened with a certain type of chemotherapy medicine that can burn or blister your skin with side effects, including pain, swelling, redness and hardening at the site of infusion. Death of skin tissue has happened in some people getting this type of chemotherapy medicine. Tell your healthcare provider right away if you get any infusion site side effects.

Side effects seen with fosaprepitant capsules may also be seen with fosaprepitant.

  • upset stomach and pain
  • trouble sleeping (insomnia)
  • hair loss (alopecia)
  • fever
  • ringing in the ears
  • slow heart rate
  • ulcers
  • disorientation

Ask your physician or pharmacist for more information. Both have a more complete list of side effects. Tell your physician or pharmacist promptly about these or any other unusual symptoms.

IMPORTANT: PLEASE READ

SERIOUS SIDE EFFECTSAND WHAT TO DO ABOUT THEM
Symptoms / EffectsTalk to your healthcare professionalStop taking drug and get immediate medical help
Only if severeIn all cases
UncommonAllergic reactions, which may be sudden and/or serious, and may include: swelling (face, eyes, lips, tongue, throat and skin), rash, itching, redness of the face/skin, difficulty in breathing/ swallowing, and serious decrease of blood pressure.✓
UncommonStevens- Johnson syndrome/toxic epidermal necrolysis (severe skin reactions, blistering)✓
UncommonUrticaria (severe rash, itching, swelling of the hands and feet)✓

This is not a complete list of side effects. For any unexpected effects while taking Fosaprepitant for Injection, contact your physician or pharmacist.

HOW TO STORE IT

Vials: Sterile powder for intravenous use. Store at 2°C to 8°C. Do not freeze. Protect from light.

Keep Fosaprepitant for Injection and all medicines safely away from children.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada.html) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice

MORE INFORMATION

If you want more information about Fosaprepitant for Injection:

  • Talk to your healthcare professional
  • Find the full product monograph that is prepared for healthcare professionals and includes this Consumer Information by visiting the https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html or by calling Juno Pharmaceuticals Corp. at 1-855-819-0505.

To report an adverse event related to Fosaprepitant for Injection, please contact 1-866-663-1747.

Juno Pharmaceuticals Corp.

402-2233 Argentia Road,

Mississauga, ON, L5N 2X7

Last revised: JUL 11, 2024

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02549379

Revision date stated in the text: July 11, 2024

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Fosaprepitant for Injection

Rx or OTC
Prescription (Rx)?
DIN 02549379
Schedule(s) PRESCRIPTION
Active ingredient(s) Fosaprepitant (fosaprepitant dimeglumine) 150 MG
Dosage form(s) Powder For Solution
Route(s) of administration Intravenous
Company JUNO PHARMACEUTICALS CORP.
Current status Marketed
Current status date August 7, 2025

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.