Jamp Ketorolac: Uses, Side Effects and Dosage

Heart and blood vessel problems:

• JAMP Ketorolac can cause heart and blood vessel problems like heart attacks, stroke, blood clots, high blood pressure and heart failure. These can lead to death.
• The risk of having heart problems is higher if you take JAMP Ketorolac for long periods of time and / or at higher doses and / or in people who have heart disease.
• Tell your healthcare professional if you have or had heart attacks, chest pain, heart disease, stroke, heart failure, high blood pressure or diabetes.

Stomach and intestine (gastrointestinal) problems:

• JAMP Ketorolac can cause stomach and intestine problems like ulcers, inflammation, bleeding, holes / perforation, blockage or pain.

Talk to your healthcare professional about any medical conditions you have and medicines you are taking.

Pregnancy:

• DO NOT take JAMP Ketorolac if you are pregnant and in a later stage of pregnancy (28 weeks or later).
• If you are pregnant and in an earlier stage of pregnancy (less than 28 weeks) only take JAMP Ketorolac if you are told to do so by your healthcare professional.
• Medicines like JAMP Ketorolac may cause harm to you and your baby. Your healthcare professional will need to closely monitor your health and that of your baby (including your amniotic fluid levels) if they prescribe JAMP Ketorolac during this time.
• Tell your healthcare professional right away if you become pregnant, think you may be pregnant or want to get pregnant during your treatment with JAMP Ketorolac.

• after surgery (including dental procedures) or giving birth. The maximum duration of treatment is 5 days.
• for an injury causing muscle or joint pain. The maximum duration of treatment is 7 days.

• JAMP Ketorolac belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It can reduce the chemicals produced by your body which cause pain and swelling.
• JAMP Ketorolac only treats the symptoms and relieves pain and inflammation as long as you take it. JAMP Ketorolac does not cure the illness or stop it from getting worse.

Serious Drug Interactions

Do not take JAMP Ketorolac with:

• acetylsalicylic acid (ASA) or other NSAIDs, used to treat pain, fever and inflammation (e.g., celecoxib, diclofenac, ibuprofen, indomethacin, ketorolac, meloxicam, naproxen);
• pentoxifylline (also known as oxpentifylline), used to improve blood circulation;
• probenecid, used to treat gout.

Taking JAMP Ketorolac with these medicines may cause serious drug interactions. Ask your healthcare professional if you are unsure you are taking these medicines.

• antacids, used to treat symptoms of excess stomach acid.
• medicines used to treat depression (antidepressants), like citalopram, fluoxetine, paroxetine, sertraline, and lithium.
• medicines used to treat high blood pressure, like enalapril, lisinopril, perindopril, ramipril, candesartan, irbesartan, losartan, and valsartan.
• medicines used to lower extra fluid levels (diuretics), like furosemide, and hydrochlorothiazide.
• medicines used as blood thinners or to prevent blood clots, like warfarin, clopidogrel, heparin, and dextrans.
• medicines used to treat seizures or epilepsy (antiepileptics), like carbamazepine and phenytoin.
• cyclosporin and tacrolimus, used to lower the risk of organ transplant rejection.
• methotrexate and pemetrexed, used to treat different cancers.
• digoxin, used to treat heart disorders.
• corticosteroids, used to treat inflammation, like glucocorticoids such as prednisone.
• mifepristone, used for abortions. JAMP Ketorolac should not be taken for 8 to 12 days after taking mifepristone.
• medicines used to treat bacterial infections (antibiotics), like aminoglycosides and quinolone antibiotics.
• opioids, used to relive pain.
• thiothixene, used to treat schizophrenia.
• alprazolam, used to manage symptoms of anxiety.
• zidovudine, used to prevent and treat human immunodeficiency virus HIV.
• medicines used to treat muscle spasms and back pain (muscle relaxants).
• alcohol.

• Take exactly as your healthcare professional has told you. They should recommend the lowest dose possible for your treatment for the shortest time needed.
• Your healthcare professional will check if JAMP Ketorolac is working for you and if it is causing you any unwanted effects. They may change your dose depending on how you respond to JAMP Ketorolac.
• To lessen stomach upset, take this medicine immediately after a meal (with food or milk). However, taking JAMP Ketorolac with food may delay the onset of pain relief. If stomach upset (indigestion, nausea, vomiting, stomach pain or diarrhea) occurs and continues, contact your healthcare professional.
• You should remain standing or sitting upright for about 15 to 30 minutes after taking this medicine. This helps to prevent irritation that may lead to trouble swallowing.
• This medication has been prescribed specifically for you. Do NOT give it to anyone else. It may harm them, even if their symptoms seem to be similar to yours.

• The usual dose is 10 mg every 4 to 6 hours as needed.
• Maximum duration of treatment: 5 days.

• The usual dose is 10 mg every 4 to 6 hours as needed.
• Maximum duration of treatment: 7 days.

• nausea or vomiting;
• abnormally fast, slow or deep breathing;
• abdominal pain, ulcer or bleeding from the stomach or gut;
• kidney problems;
• high blood pressure;
• coma.

• Nausea, vomiting, diarrhea, constipation, stomach upset, heartburn, indigestion, feeling gassy;
• Headache, dizziness, light-headedness;
• Feeling tired, trouble sleeping, abnormal dreams;
• Feeling of burning or prickling of the skin;
• Anxiety, nervousness;
• Thirst, dry mouth, sore throat, changes in tastes;
• Bruises, rash;
• Muscle pain/twitching/weakness;
• Mouth sores;
• Increased sweating;
• Bruising;
• Hair loss;
• Increased sensitivity to light.

Gastrointestinal (GI) problems (bleeding, blockage, holes, ulcers or inflammation in your GI tract): blood in vomit, black tarry or bloody stool, dizziness, stomach pain, bloating, loss of appetite, weight loss, nausea, vomiting, constipation or

diarrhea, chills or fever

Anaphylaxis / hypersensitivity

(severe allergic reactions):

sudden wheeziness and chest

Blood problems (low white and/or red blood cell or platelet count): feeling tired or weak, pale skin, bruising or bleeding for longer than usual if you hurt

yourself, fever, chills

Congestive heart failure (heart does not pump blood as well as it should): shortness of breath, fatigue and weakness, swelling in ankles, legs and feet, cough, fluid retention, lack of appetite, nausea, rapid or irregular

heartbeat, reduced ability to exercise

Cystitis (bladder infection): increased need to urinate, pain in the pelvis or lower back, frequent urination during the night, cloudy urine that may contain blood, burning or pain

urinating

Depression (sad mood that will not go away): difficulty sleeping or sleeping too much, changes

in appetite or weight, reduced sex drive and thoughts of death or suicide.

Kidney disorder / problems (including kidney failure and renal papillary necrosis): nausea, vomiting, fever, swelling of extremities, fatigue, thirst, dry skin, irritability, dark urine, increased or decreased urine output, blood in the urine, rash, weight gain (from retaining fluid), loss of appetite, mental status changes (drowsiness, confusion, coma,

painful urination, chills, back pain)

Liver problems (including hepatitis, liver failure, cholestasis): yellowing of your skin and eyes (jaundice), right upper stomach area pain or swelling, nausea or vomiting,

unusual dark urine, unusual tiredness

Lung problems (including asthma): increased shortness of breath, wheezing, difficulty breathing, cough, chest tightness, irregular heartbeat,

lung infection, chest pain, fever

Myocardial infarction (heart attack): pressure or squeezing pain between the shoulder blades, in the chest, jaw, left arm or upper abdomen, shortness of breath, dizziness, fatigue, light-headedness,

clammy skin, sweating, indigestion, anxiety, feeling faint and possible irregular heartbeat.

Stroke (bleeding or blood clot in the brain): sudden numbness, weakness or tingling of the face, arm, or leg, particularly on one side of the body, sudden headache, blurry vision, difficulty swallowing or speaking, or lethargy, dizziness, fainting, vomiting, trouble

understanding, trouble with walking and loss of balance

Tinnitus (hearing problems): includes ringing, buzzing, clicking or hissing in ears, loss of

hearing

Vertigo (a sense of severe

spinning dizziness, light- headedness)

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.