Jamp Trospium: Uses, Side Effects and Dosage

What the medication is used for:

JAMP Trospium is an antispasmodic agent used to treat overactive bladder. Patients with overactive bladder have these symptoms: a strong need to urinate right away (urgency) with or without urge incontinence (leaking or wetting accidents caused by a sudden, unstoppable urge to urinate), usually with a need to urinate often (frequent bathroom visits), and nocturia (having to urinate frequently during the night).

What it does:

The term “overactive bladder” refers to the involuntary spasm of the bladder muscle (detrusor). Overactive bladder happens when you cannot control your bladder muscle contractions.

When these muscle contractions happen too often or cannot be controlled, you get symptoms of overactive bladder (see “What the medication is used for:”).

JAMP Trospium blocks involuntary contractions of the bladder muscle (detrusor) which allows the muscle to relax giving you better control of your bladder.

JAMP Trospium reduces (see also “What this medication is used for”):

• the strong need to urinate right away
• the number of bathroom visits during the day or night
• the number of wetting accidents

You should begin to notice an improvement in your symptoms in about a week.

When it should not be used:

JAMP Trospium should not be used by patients with or at risk for:

• an inability to empty the bladder (urinary retention);
• delayed emptying of the stomach (gastric retention);
• an eye problem called “uncontrolled narrow-angle glaucoma”;
• a history of any allergic or other severe reaction to JAMP Trospium or any of its components.

What the medicinal ingredient is:

Trospium chloride

What the nonmedicinal ingredients are:

microcrystalline cellulose, lactose monohydrate, povidone, croscarmellose sodium, colloidal silicon dioxide, stearic acid, sucrose, polyethylene glycol, carboxy methyl cellulose sodium, calcium carbonate, talc, ferric oxide yellow, titanium dioxide, hypromellose, glycerin, shellac glaze, ferrosoferric oxide, propylene glycol and ammonium hydroxide.

What dosage forms it comes in:

JAMP Trospium is available as a coated tablet (20 mg).

BEFORE you use JAMP Trospium talk to your doctor or pharmacist if:

• you have trouble emptying your bladder

  (slow urinary stream), because of the risk of urinary retention;

• you have delayed or slow emptying of your stomach because of the risk of gastric retention;
• you have ulcerative colitis (ulcers in the large intestine or colon), intestinal atony or myasthenia gravis (muscle weakness);
• you have an eye problem called “narrow-angle glaucoma” that is being treated;

• you have liver or kidney disease (see “PROPER

  USE OF THIS MEDICATION”, Usual dose);

• you have congestive heart failure, hypokalemia

  (low potassium), or other conditions which may increase the risk of JAMP Trospium affecting your heart rate;

• you have heart disease

• you are pregnant, planning on becoming pregnant or are breast feeding;

The safety and effectiveness of trospium chloride has not been studied in children.

Although uncommon, JAMP Trospium may cause blurred vision and/or drowsiness in some people. Until you know how JAMP Trospium affects you, caution should be exercised when driving or operating heavy machinery.

Consumption of alcohol while taking JAMP Trospium may make drowsiness worse.

Due to decreased sweating, heat prostration (overheating of the body) can occur when drugs such as JAMP Trospium are used in a hot environment.

Drugs that may interact with JAMP Trospium include: anticholinergic agents (such as amantadine, tricyclic antidepressants, quinidine, antihistamines, and disopyramide), beta agonists (such as salbutamol or formoterol), prokinetic agents (such as metoclopramide) and drugs that are eliminated by active renal secretion (such as digoxin, procainamide, pancuronium, morphine, vancomycin, metformin and ABOUT THIS MEDICATION WARNINGS AND PRECAUTIONS

INTERACTIONS WITH THIS MEDICATION

tenofovir).

Tell your doctor or pharmacist about every medication you are taking including those you are taking without a prescription as well as any natural health products (herbal or vitamins).

Interactions with herbal medicines have not been studied.

Taking JAMP Trospium with food reduces the amount of medication that will get into your body. (see “PROPER USE OF THIS MEDICATION”).

Usual dose:

Take one JAMP Trospium 20 mg tablet twice a day on an empty stomach at least one hour before meals. For patients with kidney disease the recommended dose of JAMP Trospium is 20 mg once a day. In geriatric patients 75 years of age and older, the dose may be reduced to 20 mg once daily if twice daily dosing is not well tolerated.

Trospium chloride has not been studied in children.

Overdose:

Overdosage with JAMP Trospium may result in severe anticholinergic effects such as rapid and irregular heartbeat, flushed face, fever, ringing in the ears, and muscle spasms.

If you think you have taken an overdose of JAMP Trospium, go to your nearest emergency room immediately. If possible, bring the package with you.

Missed Dose:

If you miss a dose, take your next dose at the usual time (on an empty stomach at least 1 hour before your next meal). Do not double the next dose to make up for the missed dose.

Common side effects:

In clinical studies, the most common side effects with trospium chloride were dry mouth, constipation and abdominal pain.

Other side effects:

The following less common events may also occur with the use of JAMP Trospium: dyspepsia (upset stomach), nausea, dizziness, flatulence, chest pain, dry eyes, blurred vision, increased heart rate, palpitation, urinary retention, and heat prostration.

Due to decreased sweating, heat prostration (overheating of the body) can occur when drugs such as JAMP Trospium are used in a hot environment. Be sure to consume adequate amounts of liquid if you are in a hot environment for a prolonged period of time.

Tell your doctor or pharmacist if you have any side effects that bother you or don’t go away.

The following events have rarely been reported during trospium chloride use: Anaphylactic, Stevens-Johnson and toxic epidermal necrolysis reactions (rare, life-threatening, allergic reactions), angioedema (serious allergic reaction which can cause swelling of the face or throat), tachycardia (rapid heartbeat), syncope (fainting), myalgia (muscle pain), arthralgia (joint pain), rhabdomyolysis (destruction of muscle tissue), hallucinations, confusion, agitation, and hypertensive crisis (sudden, marked increase in blood pressure). If you think you are experiencing any of these rare effects, stop taking JAMP Trospium immediately and go to the emergency room.

This is not a complete list of side effects. For any unexpected effects while taking JAMP Trospium, contact your doctor or pharmacist.

Store at controlled room temperature 15° to 30°C. Preserve in tight containers, protect from light. Keep out of reach and sight of children.

REPORTING SUSPECTED SIDE EFFECTS

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction

  Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or

• Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

PROPER USE OF THIS MEDICATION

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

HOW TO STORE IT

If you want more information about JAMP Trospium:

• Talk to your healthcare professional

• Find the full product monograph that is prepared for healthcare professionals and includes this Consumer Information by visiting the Health Canada website (https://health-

  products.canada.ca/dpd-bdpp/index-eng.jsp); or by calling 1-866-399-9091

Boucherville, Québec

J4B 5H3

Last Approved: October 15, 2020

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