Patient Medication Information: uses, side effects, how to take - Jamp Voriconazole
Serious warnings and precautions box
For more information, see the To help avoid side effects and ensure proper use... including if you: and the Serious side effects and what to do about them sections below. |
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What JAMP Voriconazole is used for:
- JAMP Voriconazole is used to treat certain fungal infections, specifically Aspergillus or Candida infections.
How JAMP Voriconazole works:
JAMP Voriconazole works by killing or interfering with the growth of fungi which helps stop the infection.
The ingredients in JAMP Voriconazole are:
Medicinal ingredient: Voriconazole.
Non-medicinal ingredients: Colloidal silicon dioxide, croscarmellose sodium, hypromellose, lactose monohydrate, magnesium stearate, povidone, pregelatinized starch, starch-maize, titanium dioxide and triacetin.
JAMP Voriconazole comes in the following dosage forms:
Voriconazole tablets: 50 mg and 200 mg.
Do not use JAMP Voriconazole if:
- You are allergic to voriconazole or any of the other ingredients of JAMP Voriconazole (see The ingredients in JAMP Voriconazole are: section above).
- You are taking other medication that must not be taken with JAMP Voriconazole (see the Serious Drug Interactions box below).
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take JAMP Voriconazole. Talk about any health conditions or problems you may have, including if you:
- have a history of heart disease, or an irregular heartbeat.
- have had any drug allergies including allergic reactions to other drugs known as “azoles”.
- have or had liver problems.
- have or had kidney problems.
- think you have galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Check with your healthcare professional before starting to take JAMP Voriconazole tablets since they contain lactose monohydrate.
are pregnant or planning to become pregnant. Do not take JAMP Voriconazole while you are pregnant unless your healthcare professional tells you to do so. Use effective contraception methods if you are of childbearing age. Contact your healthcare professional right away if you become pregnant while taking JAMP Voriconazole.
- are breastfeeding or planning to breastfeed. Do not take JAMP Voriconazole during breastfeeding. It is not known if JAMP Voriconazole passes in breast milk. Ask your healthcare professional for advice before taking any medicine while breastfeeding.
Other warnings you should know about:
While being treated with JAMP Voriconazole:
- tell your healthcare professional immediately if you develop serious skin reactions such as rash, red skin, blistering of lips, eyes or mouth, skin peeling accompanied by fever, and skin lesions.
- avoid strong sunlight while being treated with JAMP Voriconazole. Wear protective clothing and use sunscreen. Tell your healthcare professional if your skin becomes more sensitive to the sun.
- your healthcare professional may wish to monitor the function of your liver and kidneys by doing blood tests.
- JAMP Voriconazole may affect your vision (e.g., make your eyes blurry). Do not drive or perform complex tasks if you have problems with your eyes. You should not drive at night while taking JAMP Voriconazole.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
Serious drug interactions:
The following list of medicines must not be taken during your course of JAMP Voriconazole treatment:
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The following may also interact with JAMP Voriconazole:
- Cyclosporine (a medicine used in transplant patients).
- Tacrolimus (a medicine used in transplant patients).
- Tricyclic antidepressants (medicines used to treat depression).
- Antiarrhythmics (medicines that stabilize heart function, e.g., such as procainamide, amiodarone, quinidine, and sotalol).
- Antipsychotic drugs (medicines used to treat psychotic disorders).
- HIV protease inhibitors (medicines used to treat HIV).
- Macrolide antibiotics (medicines used to treat bacterial infections).
- Methadone (a medicine used to treat pain).
- Oral contraceptives (medicines used for birth control).
- Short-acting opiates (medicines used to treat pain, e.g., alfentanil and sufentanil).
- Long-acting opiates (medicines used to treat pain, e.g., oxycodone and fentanyl).
- Some oral anticoagulants (medicines used to prevent blood clots, e.g., warfarin and coumarin).
- Fluconazole (a medecine used for fungal infections).
- Everolimus (a medicine used for treating advanced kidney cancer and in transplant patients).
- Benzodiazepines (medicines used to treat anxiety, insomnia, and seizures, e.g., alprazolam).
- Calcium channel blockers (medicines used to treat heart conditions).
- Sulfonylureas (medicines used to treat diabetes, e.g., glyburide and glipizide).
- Letermovir (a medicine used to treat viral infections).
- Ivacaftor (a medicine used to treat cystic fibrosis).
- Corticosteroids (medicines used to treat inflammation, e.g., prednisolone, budesonide).
- Lemborexant (a medicine used to treat insomnia).
- Glasdegib (a medicine used to treat acute myeloid leukemia).
- Tretinoin (a medicine used to treat acute promyelocytic leukemia).
- Tyrosine kinase inhibitors (medicines used to treat cancer, e.g., axitinib and bosutinib).
Tell your healthcare professional if you are taking nonsteroidal anti-inflammatories (NSAIDS) (medicines used for treating pain and inflammation) including ibuprofen and diclofenac, as the NSAID dose may have to be adjusted.
How to take JAMP Voriconazole:
JAMP Voriconazole has been prescribed for you. Do not allow anyone else to take it. This product should only be taken under the supervision of a healthcare professional.
Usual dose:
Usual Adult Dose:
Your healthcare professional will determine your dose depending on your weight and the type of infection (or suspected infection) you have.
Always take JAMP Voriconazole exactly as directed by your healthcare professional. You should check with your healthcare professional if you are unsure. Never change the dose yourself.
Your healthcare professional will prescribe a higher dose of JAMP Voriconazole on your first day of treatment. This will help your body quickly obtain an effective blood level of the antifungal.
JAMP Voriconazole tablets:
| Infection Type | First 24 hours | After the first 24 hours | ||||||||
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| 40 kg or more | Less than 40 kg | 40 kg or more | Less than 40 kg | |||||||
| Aspergillus | 400 mg twice a day (two 200 mg tablets) | 200 mg twice a day (one 200 mg tablet) | 200 mg twice a day (one 200 mg tablet) | 100 mg twice a day (two 50 mg tablets) | ||||||
| Candida | ||||||||||
JAMP Voriconazole tablets must be taken at least one hour before or two hours after a meal. Swallow the tablet whole with some water.
If you have liver disease, your healthcare professional may prescribe a lower dose of JAMP Voriconazole. Your healthcare professional may order periodic blood tests to monitor your liver function during JAMP Voriconazole treatment.
Continue taking JAMP Voriconazole until your healthcare professional tells you to stop. Do NOT stop treatment early because your infection may not be cured. Patients with a weakened immune system or those with difficult infections may require long-term treatment to prevent the infection from returning.
Overdose:
| If you think you, or a person you are caring for, have taken too much JAMP Voriconazole, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms. |
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Take your bottle of JAMP Voriconazole tablets with you.
Missed Dose:
If you miss taking a dose of JAMP Voriconazole, just take the next dose when it is due. Do NOT take a double dose to make up for the forgotten dose.
Possible side effects from using JAMP Voriconazole:
These are not all the possible side effects you may have when taking JAMP Voriconazole. If you experience any side effects not listed here, tell your healthcare professional.
Side effects may include:
- fever,
- rash,
- nausea,
- vomiting,
- diarrhea,
- headache,
- swelling of the extremities (hands and feet),
- stomach pain,
- dizziness,
- itchiness,
- weakness,
- back pain,
- chest pain,
- flu-like symptoms,
- facial swelling,
- tingling,
- cough,
- hair loss,
- pain and irritation of the eyes,
- sensitivity to light and sun (photosensitivity).
Patients taking JAMP Voriconazole alone or taking JAMP Voriconazole along with corticosteroids long-term have experienced adrenal problems with symptoms of dizziness, fatigue, loss of appetite, nausea and vomiting.
Serious side effects and what to do about them
| Frequency/Side Effect/Symptom | Talk to your healthcare professional | Stop taking the drug and get immediate medical help | |||
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| Frequency/Side Effect/Symptom | Talk to your healthcare professional | Stop taking the drug and get immediate medical help | |||
| Only if severe | In all cases | ||||
| Only if severe | In all cases | ||||
| Uncommon | |||||
| Bone and joint pain | √ | ||||
| Hallucination | √ | ||||
| Heart failure (heart does not pump blood as well as it should): shortness of breath, fatigue and weakness, swelling in ankles, legs and feet, cough, fluid retention, lack of appetite, nausea, rapid or irregular heartbeat, reduced ability to exercise. | √ | ||||
Hyponatremia (low levels of sodium in the blood): nausea, vomiting, confusion, weakness, fatigue, cramps, decreased consciousness, seizures. | √ | ||||
| Irregular heartbeat | √ | ||||
Kidney problems: nausea, vomiting, fever, swelling of hands and feet, fatigue, thirst, dry skin, irritability, dark urine, increased or decreased urine output, rash, weight gain (from retaining fluid), loss of appetite, abnormal blood test results, drowsiness, confusion. | √ | ||||
Liver problems: yellowing of the skin, itching, feeling more tired than usual or like you have the flu, stomach pains or nausea and vomiting. | √ | ||||
| Pancreatitis (inflammation of the pancreas): persistent abdominal pain and tenderness, vomiting. | √ | ||||
Peripheral neuropathy (nerve damage): burning pain, tingling, numbness, sensitivity to touch, weakness. | √ | ||||
Severe Cutaneous Adverse Reactions (SCAR): severe skin reactions that may also affect other organs:
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| Visual disturbances (eye problems): blurring of vision, reduced vision, colour vision change and increased sensitivity to light. | √ | ||||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
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Storage:
Keep out of reach and sight of children.
Store JAMP Voriconazole tablets at room temperature, 15-30°C. Do not use after the expiry date stated on the packaging.
If you want more information about JAMP Voriconazole:
- Talk to your healthcare professional;
- Find the full Product Monograph that is prepared for healthcare professionals and includes the Patient Medication Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); or by calling 1-866-399-9091.
JAMP Pharma Corporation
1310 rue Nobel
Boucherville, Québec
J4B 5H3, Canada