Kerendia: Uses, Side Effects and Dosage

What KERENDIA is used for:

KERENDIA is used in adults:

• along with other medicines to treat chronic kidney disease and type 2 diabetes to:

  • slow the worsening of kidney damage; and
  • lower the risk of dying from heart or blood vessel disease, having a heart attack, and being hospitalized for heart failure.

• along with other medicines to treat heart failure to:

  • lower the risk of dying from heart or blood vessel disease; and
  • reduce hospital stays and emergency visits for heart failure.

How KERENDIA works:

Your body makes a substance called aldosterone. Aldosterone is important to control blood pressure by acting on the kidney and the heart. Sometimes high levels of aldosterone may worsen your kidney and heart function. KERENDIA works by stopping the action of aldosterone and can help prevent damage to your kidneys and heart.

The ingredients in KERENDIA are:

Medicinal ingredient(s): finerenone.

Non-medicinal ingredients: cellulose microcrystalline, croscarmellose sodium, ferric oxide red (only for the 10 mg and 40 mg tablets), ferric oxide yellow (only for the 20 mg and 40 mg tablets), hypromellose 5 cP, lactose monohydrate, magnesium stearate, sodium laurilsulfate, talc, and titanium dioxide.

KERENDIA comes in the following dosage form(s):

Tablet (film-coated): 10 mg, 20 mg, and 40 mg of finerenone.

Do not use KERENDIA if:

• you are allergic to finerenone or any of the other ingredients of this medicine. KERENDIA tablets contain lactose.

• you are taking any medicines known as ‘strong CYP3A4 inhibitors’. Examples include:

  • itraconazole or ketoconazole – used to treat infections caused by a fungus or yeast;
  • ritonavir, nelfinavir, or cobicistat – used to treat HIV infection;
  • clarithromycin – used to treat bacterial infections;
  • telithromycin – used to treat pneumonia;
  • nefazodone – used to treat depression.
• you have Addison’s disease.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take KERENDIA. Talk about any health conditions or problems you may have, including if you:

• have or have had a high level of potassium in your blood (hyperkalemia).
• have severe loss of kidney function (severe renal impairment) or kidney failure (end-stage renal disease).
• have moderate or severe liver damage (moderate or severe hepatic impairment or Child Pugh B or C).

• have one of the following rare hereditary diseases, because KERENDIA contains lactose:

  • galactose intolerance,
  • Lapp lactase deficiency,
  • glucose-galactose malabsorption.
• are pregnant, think you are pregnant, or are planning to become pregnant.
• are breastfeeding or are planning to breastfeed. You should not breastfeed while taking KERENDIA.

Other warnings you should know about:

Pregnancy: KERENDIA may harm your unborn baby. If you become pregnant while taking KERENDIA, tell your healthcare professional right away. KERENDIA should not be taken during pregnancy unless you and your healthcare professional have decided you should. If you are of child-bearing potential, use a reliable method of birth control.

Check-Ups: During treatment with KERENDIA, your healthcare professional will perform regular blood tests to monitor:

• your potassium levels, and
• your kidney function.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

Serious drug interactions:

Serious drug interactions with KERENDIA include:

• medicines known as ‘strong CYP3A4 inhibitors’. These medicines strongly decrease the activity of a class of enzymes in your body, called ‘CYP3A4 enzymes’. Examples include:

  • itraconazole or ketoconazole – used to treat infections caused by a fungus or yeast;
  • ritonavir, nelfinavir, or cobicistat – used to treat HIV infection;
  • clarithromycin – used to treat bacterial infections;
  • telithromycin – used to treat pneumonia;
  • nefazodone – used to treat depression.

Do not take KERENDIA if you are taking any of the medicines noted above.

The following may also interact with KERENDIA:

• Medicines known as ‘weak or moderate CYP3A4 inhibitors’. These medicines decrease the activity of a class of enzymes in your body, called ‘CYP3A4 enzymes’. Examples include:

  • erythromycin – used to prevent and treat bacterial infections;
  • verapamil – used to treat high blood pressure, chest pain, and fast heartbeat;
  • fluvoxamine – used to treat depression and ‘obsessive-compulsive disorder (OCD)’.

If you take 10 mg, 20 mg or 40 mg of KERENDIA while taking any of these medicines, you may get too much of the active substance, finerenone, in your blood. You may have more side effects.

• Medicines known as ‘moderate or strong CYP3A4 inducers’. These medicines increase the activity of a class of enzymes in your body, called ‘CYP3A4 enzymes’. Examples include:

  • rifampicin – used to treat bacterial infections;
  • carbamazepine, phenytoin, or phenobarbital – used to treat seizures;
  • St. John’s Wort (a herbal product) – used to treat depression;
  • efavirenz – used to treat HIV infection.

If you take 10 mg, 20 mg or 40 mg of KERENDIA while taking any of these medicines, you may not get enough of the active substance, finerenone, in your blood. KERENDIA may not work as expected.

• Medicines that may increase the level of potassium in your blood. Examples include:

  • ‘water pills’ – used to remove excess water from your body in urine (potassium-sparing diuretics), such as amiloride or triamterene;
  • other medicines like finerenone, such as eplerenone or spironolactone;
  • trimethoprim, or a combination of trimethoprim and sulfamethoxazole – used to treat bacterial infections;
  • potassium supplements.

If you take 10 mg, 20 mg or 40 mg of KERENDIA while taking any of these medicines, you may get too much potassium in your blood (hyperkalemia). This may be unsafe for you.

• Medicines known as ‘sensitive CYP3A4 or CYP2C8 substrates’ that have a small difference between a helpful dose and a harmful dose. Examples include:

  • cyclosporin or tacrolimus– used to help prevent the body from attacking a transplanted organ;
  • paclitaxel – used to treat various types of cancer.

If you take 40 mg of KERENDIA while taking either of these medicines, some of these medicines may not work as expected and you may have unwanted side effects. Your healthcare professional should review your other medications and decide on possible changes.

• Grapefruit or grapefruit juice.

How to take KERENDIA:

• Always take KERENDIA exactly as your healthcare professional has told you.
• Try to take KERENDIA at the same time every day.

• You can take KERENDIA with a glass of water, with or without food. However, do not eat grapefruit or drink grapefruit juice while taking KERENDIA.

• If you cannot swallow the whole tablet, you can crush the tablet and mix it with water or soft foods (e.g., applesauce). Take the mixture right away.

Usual dose:

Your healthcare professional will decide the best dose for you. This will depend on your condition, current health, if you are taking other medicines, and how you react to KERENDIA.

The usual dose is 1 tablet per day.

The maximum dose of KERENDIA is:

• 20 mg per day for type 2 diabetes and chronic kidney disease.
• 40 mg per day for heart failure.

Your healthcare professional will perform blood tests during your treatment to see how you react to KERENDIA. Depending on the results, your healthcare professional may change your dose.

Overdose:

If you think you, or a person you are caring for, have taken too much KERENDIA, contact a healthcare professional, hospital emergency department, regional poison control centre, or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

Missed dose:

Do not take 2 tablets on the same day to make up for a missed dose. If you forget to take your dose and it is still the same day, take the tablet as soon as you remember. If it is the next day, skip the missed dose and take your next dose as scheduled.

Possible side effects from using KERENDIA:

These are not all the possible side effects you may have when taking KERENDIA. If you experience any side effects not listed here, tell your healthcare professional.

Side effects of KERENDIA may include:

• Itchy skin

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting side effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

• Store the KERENDIA bottles or blisters at room temperature (15°C to 30°C).
• Do not use this medicine after the expiry date stated on the product labels.
• Do NOT throw away any medicines in the garbage, down the sink or in the toilet. Ask your pharmacist how to throw away expired or unused KERENDIA. These measures will help protect the environment.
• Keep out of sight and reach of children.

If you want more information about KERENDIA:

• Talk to your healthcare professional.

• Find the full Product Monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website (http://www.bayer.ca) or by calling Bayer Medical Information at 1-800-265-7382 or emailing canada.medinfo@bayer.com.

  Bayer Inc.

  2920 Matheson Blvd East,

  Mississauga, Ontario

  L4W 5R6

  Canada

Date of Authorization: 2026-01-19

© 2026, Bayer Inc.

® TM see www.bayer.ca/tm-mc