Lupin-Letermovir: Uses, Side Effects and Dosage

What is LUPIN-LETERMOVIR used for?

LUPIN-LETERMOVIR is a prescription medicine to help to keep adults 18 years of age and older from getting ill from CMV (cytomegalovirus). CMV is a virus. For most people, CMV doesn’t hurt them. However, if your immune system is weak after you get a stem cell (bone marrow) transplant, you may be at high risk of becoming ill from CMV.

How does LUPIN-LETERMOVIR work?

LUPIN-LETERMOVIR is an antiviral medicine. It stops CMV from multiplying.

What are the ingredients in LUPIN-LETERMOVIR?

Medicinal ingredients: letermovir

Non-medicinal ingredients: Tablets: colloidal silicon dioxide, croscarmellose sodium, magnesium stearate, microcrystalline cellulose and povidone (K 30).

The tablets are film-coated with a coating material containing the following inactive ingredients: Opadry II Pink 32K540095 IH for 480 mg and, Opadry II Yellow 32K520094 IH for 240 mg.

LUPIN-LETERMOVIR comes in the following dosage forms:

Tablet: 240 mg and 480 mg

LUPIN-LETERMOVIR is only available as a tablet. Letermovir injection products from other sources may be prescribed by your healthcare professional.

Do not use LUPIN-LETERMOVIR if you:

• are allergic to letermovir, or any of the other ingredients of LUPIN-LETERMOVIR.

• are taking any of the following medicines:

  • Pimozide (for Tourette’s syndrome).
  • Ergot alkaloids (for migraine headaches).

If you are taking LUPIN-LETERMOVIR with cyclosporine, do not take lovastatin, rosuvastatin, simvastatin, or bosentan.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take LUPIN-LETERMOVIR. Talk about any health conditions or problems you may have, including if you:

• have kidney disease.
• have liver disease.

• are a pregnant woman or trying to get pregnant. It is not known if LUPIN-LETERMOVIR will harm your baby while you are pregnant.

• are breastfeeding or plan to breastfeed. It is not known if LUPIN-LETERMOVIR gets in your breast milk and will be passed to your baby.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with LUPIN-LETERMOVIR:

• If you take any of these medicines, be sure to tell your doctor:

  • Alfentanil, fentanyl (for severe pain)
  • Amiodarone (used to correct irregular heartbeats)
  • Midazolam (used as a sedative)
  • Cyclosporine, tacrolimus, sirolimus (used to prevent transplant rejection)
  • Voriconazole (for fungal infections)
  • Statins, such as atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, simvastatin (for high cholesterol)
  • Omeprazole, pantoprazole (for stomach ulcers and other stomach problems)
  • Glyburide, repaglinide, rosiglitazone (for high blood sugar)
  • Carbamazepine, phenobarbital, phenytoin (for seizures or convulsions)
  • Warfarin (used as a blood thinner or for blood clots)
  • Rifabutin, rifampin (for mycobacterial infections)
  • Bosentan (for high blood pressure in the vessels of the lungs)
  • St. John’s wort (Hypericum perforatum) (an herbal product)
  • Efavirenz, etravirine, nevirapine (for HIV)
  • Modafinil (for wakefulness)
• Know the medicines you take. Keep a list of medicines and show it to your doctor and pharmacist when you get a new medicine.
• You can ask your doctor or pharmacist for a list of medicines that may interact with LUPIN-LETERMOVIR.
• Do not start or stop taking another medicine without telling your doctor first.

How to take LUPIN-LETERMOVIR:

• You can receive LUPIN-LETERMOVIR as tablets by mouth.
• It is important that you do not miss or skip doses of LUPIN-LETERMOVIR.

Usual dose:

If you take the tablets:

• Take 1 tablet once a day.

  • Take it at the same time every day.

  • Take it with or without food.

  • Swallow the tablet whole. Do not break, crush, or chew the tablet.
• Take this medicine exactly how your doctor tells you to take it.
• Keep it in the original package until you are ready to take it.
• Do not stop taking LUPIN-LETERMOVIR without talking to your doctor first.
• Do not run out of your LUPIN-LETERMOVIR.

Overdose:

If you take more LUPIN-LETERMOVIR, than your prescribed dose, call your doctor right away.

If you think you, or a person you are caring for, have taken too much LUPIN-LETERMOVIR, contact a healthcare professional, hospital emergency department, or regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

Missed Dose:

If you forget to take the tablets:

If you forget to take your dose of LUPIN-LETERMOVIR, take it as soon as you remember.

If you do not remember until it is almost time for your next dose, skip your last dose and take the next dose at your usual time.

• Do not take two doses of LUPIN-LETERMOVIR at the same time to make up for a missed dose.
• If you are not sure what to do, call your doctor or pharmacist.

What are possible side effects from using LUPIN-LETERMOVIR?

These are not all the possible side effects you may have when taking LUPIN-LETERMOVIR. If you experience any side effects not listed here, tell your healthcare professional.

Common side effects of LUPIN-LETERMOVIR:

• nausea
• diarrhea
• vomiting

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

• Keep LUPIN-LETERMOVIR in the original package until you are ready to take it.
• Keep LUPIN-LETERMOVIR tablets at room temperature (15°C to 30°C).

Keep out of reach and sight of children.

If you want more information about LUPIN-LETERMOVIR:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html; or by calling 1-844-587-4623.

Date of preparation: APR 20, 2026