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M-Metformin (Mantra Pharma, 1000 mg): Uses, Side Effects and Dosage

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1000 mg
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Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - M-Metformin (Mantra Pharma, 1000 mg)

Serious Warnings and Precautions

Lactic Acidosis

  • M-METFORMIN may cause lactic acidosis. This is a serious condition when there is too much lactic acid in your body. It may cause death.

  • The risk of lactic acidosis is higher if you have:

    • liver, kidney or heart problems, including heart failure.
    • drink a lot of alcohol. You should not drink alcohol while taking M-METFORMIN.

  • Stop taking M-METFORMIN right away and talk to your healthcare professional if you have these symptoms:

    • discomfort, muscle pain, difficult or fast breathing, extreme tiredness, weakness, upset stomach, stomach pain, feeling cold, low blood pressure or slow heartbeat.

  • M-METFORMIN can also cause diarrhea, nausea, upset stomach, bloating, gas or loss of appetite.

    • If any of these side effects come back after you are on the same dose of M-METFORMIN for many days or weeks, tell your healthcare professional right away. These symptoms may be due to lactic acidosis.
  • Lactic acidosis must be treated in the hospital. Your healthcare professional will decide the best treatment options for you.

What is M-METFORMIN used for?

M-METFORMIN is used to improve blood sugar levels in adults with type 2 diabetes mellitus. It is used in addition to proper diet, exercise and weight loss. M-METFORMIN can be used with other antidiabetic medicines or by itself.

How does M-METFORMIN work?

  • M-METFORMIN helps to control your blood sugar. It is believed to help your body respond better to the insulin it makes naturally.
  • High blood sugar can be lowered by diet and exercise, by a number of medicines taken by mouth, and by insulin shots.
  • While you take M-METFORMIN, continue to exercise and follow the diet advised by your healthcare professional for your diabetes.

What are the ingredients in M-METFORMIN?

Medicinal ingredient: metformin hydrochloride

Non-medicinal ingredients: crospovidone, magnesium stearate, povidone and starch pregelatinised. Tablet coating is comprised of hypromellose, polyethylene glycol, and titanium dioxide.

M-METFORMIN comes in the following dosage forms:

Tablets; 1000 mg

Do not use M-METFORMIN if you:

  • have Type I diabetes that is unstable and/or insulin-dependent;
  • have metabolic acidosis (including diabetic ketoacidosis, or a history of ketoacidosis with or without coma;
  • have a history of lactic acidosis (too much acid in the blood);
  • have severe liver or kidney problems;
  • regularly drink alcohol;
  • are going to get an injection of dyes (iodinated contrast materials) for medical imaging;
  • Have heart system collapse(blood circulation failure) or heart problems that can cause hypoxemia (low oxygen in the blood);
  • are stressed, have a severe infection, or are experiencing trauma;
  • will have surgery and during recovery after your surgery;
  • suffer from severe dehydration (have lost a lot of water from your body) or shock;
  • are hypersensitive or allergic to metformin or any other ingredient in this medicine or component of the container;
  • are pregnant or planning to become pregnant;
  • are breastfeeding.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take M-METFORMIN. Talk about any health conditions or problems you may have, including if you:

  • have liver or kidney problems;
  • have a history of kidney problem;
  • are 80 years or older and you have NOT had your kidney function tested;
  • have metabolic acidosis (e.g. diabetic ketoacidosis);
  • have had a recent heart attack;
  • have had recent stroke;
  • have a serious infection;
  • are dehydrated;
  • are scheduled for surgery;
  • are scheduled for and x-ray or scanning procedures;
  • are pregnant, breast-feeding or planning to become pregnant;
  • have vitamin B12 or folic acid deficiency;
  • drink alcohol;
  • have hormone problems (adrenal or pituitary glands);
  • have low blood sugar;
  • have a low daily calorie intake.

Other warnings you should know about:

Vitamin B12 levels:

  • M-METFORMIN can cause your vitamin B12 levels to be low. This can cause peripheral neuropathy (nerve damage).

Thyroid problems:

  • M-METFORMIN can cause hypothyroidism (low thyroid hormone levels) if:

    • you have thyroid problems or if you are being treated with levothyroxine (a drug used to treat thyroid problems).
  • Your healthcare professional will monitor your thyroid health during treatment.

See the “Serious side effects and what to do about them” table, below, for more information on these and other serious side effects.

Low Blood Sugar:

  • M-METFORMIN rarely causes hypoglycemia (low blood sugar) by itself.

  • Hypoglycemia can happen if you:

    • do not eat enough;
    • drink alcohol;
    • take other medicines to lower blood sugar;
    • have hormone (adrenal or pituitary gland) or liver problems.

Check-ups and testing: You will have regular visits with your healthcare professional, before, during and at the end of your treatment. They will:

  • Do blood and urine tests to check your blood health and sugar levels.
  • Check that your heart, eyes, thyroid and liver are working properly.
  • Check your kidney health before starting treatment and during treatment with M-METFORMIN.

Patients older than 65 years old:

  • You should not take M-METFORMIN if you are older than 80 years old unless certain tests are done to check your kidney health.

Pregnancy and breastfeeding:

Female patients

  • Do not take M-METFORMIN if you are pregnant. It may harm your unborn baby.
  • Tell your healthcare professional right away if you become pregnant or think you may be pregnant during your treatment with M-METFORMIN.
  • Do not breastfeed while you are taking M-METFORMIN.

Driving and using machines: Do not drive or operate machines if you develop hypoglycemia (low blood sugar levels).

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with M-METFORMIN

  • Other diabetes medicines like glyburide, insulin, and rosiglitazone;
  • intravenous contrast dyes (such as intravenous urogram, intravenous cholangiography, angiography, and computed tomography (CT) scans with intravascular contrast material);
  • Nifedipine, used to treat high blood pressure, chest pain and Raynaud’s phenomenon;
  • Medicines used to treat heart failure and irregular heartbeats like digoxin;
  • Medicines used to treat pain like morphine;
  • Medicines used to treat irregular heartbeats like procainamide, quinidine;
  • Medicines used to lower stomach acid like ranitidine and cimetidine;
  • Medicine used to treat malaria like quinine;
  • Medicines used to treat bacterial infections (antibiotics) like trimethoprim, vancomycin;
  • Medicines used as blood thinners like phenprocoumon;
  • Medicines used to lower the extra fluid in your body (diuretics), like furosemide, amiloride, triamterene;

  • Medicines that create high blood sugar and may lead to a loss of blood sugar control. Examples include:

    • Thiazide and other diuretics (used to lower the extra fluid in your body);
    • Phenytoin, used to treat epilepsy;
    • Nicotinic acid, used to prevent and treat low niacin;
    • Isoniazid, used to treat active tuberculosis infections;
    • Corticosteroids (anti-inflammatory drugs) like prednisone;
    • Phenothiazines, used to treat mental and emotional disorders;
    • Thyroid hormone drugs, like levothyroxine;
    • Female hormones like estrogens or estrogens plus progestogen;
    • Oral birth control;
    • Sympathomimetics (used to stimulate the sympathetic nervous system);
    • Medicines used to lower blood pressure, like amlodipine, felodipine, veramapil and diltiazem;
    • Medicines for asthma such as salbutamol or formoterol.
  • Medicines used to treat high blood pressure (ACE-inhibitors) like enalapril, lisinopril and quinapril.

How to take M-METFORMIN:

  • Take exactly as your healthcare professional has told you. Check with your healthcare professional if you are not sure.

  • Take by mouth with a meal.

  • Swallow tablets whole with a glass of water. Do not break or crush tablets.

Usual dose:

  • Adults 18 years and older: Your healthcare professional will decide on the best dosage for you based on your condition.

  • Your healthcare professional may lower your dose, stop your treatment for a period of time or recommend that you stop treatment completely. This may happen if you:

    • experience serious side effects, or
    • your disease gets worse.

Overdose:

If you think you, or a person you are caring for, have taken too much M-METFORMIN, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms.

Symptoms of overdose may include:

  • rapid breathing or trouble in breathing;
  • stomach pain;
  • nausea and vomiting followed by diarrhea;
  • drowsiness, weakness, dizziness;
  • headache.

Missed Dose:

If you miss a dose of M-METFORMIN:

  • Do not take a double dose to make up for missed dose.
  • Take the next dose at the usual time.

What are possible side effects from using M-METFORMIN?

These are not all the possible side affects you may have when taking M-METFORMIN. Taking M-METFORMIN with meals can help to reduce these side effects. If you experience any side effects not listed here, tell your healthcare professional.

  • diarrhea;
  • nausea, vomiting;
  • upset stomach;
  • abdominal pain, bloating;
  • gas;
  • loss of appetite;
  • weight loss;
  • metallic taste;
  • skin problems: skin reaction, rash, itchy skin.

M-METFORMIN can cause abnormal blood test results. Your healthcare professional will do blood tests during your treatment.

Serious side effects and what to do about them

Symptom / effectTalk to your healthcare professionalStop taking drug and get immediate medical help
Only if severeIn all cases
RARE
Encephalopathy (disease of the brain that severely alters thinking): Possible neurological symptoms include: muscle weakness in one area, poor decision-making or concentration, involuntary twitching, trembling, difficulty speaking or swallowing, seizures.√
Hemolytic anemia (breakdown of red blood cells): symptoms may include fatigue, pale color, rapid heartbeat, shortness of breath, dark urine, chills, and backache.√

Lactic Acidosis (high level of acid in the blood) that can cause death: Feeling very weak, tired, or uncomfortable,

unusual muscle pain, trouble breathing, unusual or unexpected stomach discomfort, stomach pain with nausea and vomiting, or diarrhea, feeling cold, feeling dizzy or lightheaded, suddenly developing a slow or irregular

√

Serious side effects and what to do about them

Symptom / effectTalk to your healthcare professionalStop taking drug and get immediate medical help
Only if severeIn all cases
heartbeat.
Pancreatitis (inflammation of the pancreas): prolonged severe abdominal pain which may be accompanied by vomiting; pain may spread out towards the back.√
Peripheral neuropathy (a result of damage to your peripheral nerves): signs and symptoms might include gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms, sharp, jabbing, throbbing, freezing or burning pain, extreme sensitivity to touch, lack of coordination and falling, muscle weakness or paralysis if motor nerves are affected.√
VERY RARE
Liver problems: yellowing of your skin and eyes (jaundice), right upper stomach area pain or swelling, nausea or vomiting, unusual dark urine, unusual tiredness√
UNKNOWN
Hypothyroidism (underactive/low thyroid): Weight gain, tiredness, hair loss, muscle weakness, feeling cold, dry skin, constipation, puffy face, heavier than normal or irregular menstrual periods, enlarged thyroid gland.√
Photosensitivity (sensitivity to sunlight): itchy, red skin when exposed to sunlight.√

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

•

  • Store at room temperature (15°C to 30°C) in well closed containers.

•

  • Throw away any medication that is outdated or no longer needed. Talk to your pharmacist

    about the proper disposal of your medication.

•

  • Keep out of reach and sight of children.

If you want more information about M-METFORMIN:

•

  • Talk to your healthcare professional

•

  • Find the full product monograph that is prepared for healthcare professionals and includes

    this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); or by contacting Mantra Pharma Inc. at medinfo@mantrapharma.ca or at 1-833-248-7326

1000 rue Du Lux, Suite 201

Brossard, Quebec

J4Y 0E3

Date of preparation: MAY 30, 2024

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02548275

Revision date stated in the text: May 30, 2024

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for M-Metformin (Mantra Pharma, 1000 mg)

Rx or OTC
Prescription (Rx)?
DIN 02548275
Schedule(s) PRESCRIPTION
Active ingredient(s) Metformin hydrochloride 1000 MG
Dosage form(s) Tablet
Route(s) of administration Oral
Drug class (WHO ATC)
  1. A Alimentary tract and metabolism drugs
    1. A10 Drugs used in diabetes
      1. A10B Blood glucose lowering drugs, excl. insulins
        1. A10BA Biguanide blood glucose lower drugs
          1. A10BA02 Metformin
Company MANTRA PHARMA INC
Current status Marketed
Current status date November 14, 2024

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.