Mar-Ibuprofen XR: Uses, Side Effects and Dosage

What the medication is used for:

MAR-IBUPROFEN XR provides fast & effective temporary relief of pain lasting longer than 6 hours.

MAR-IBUPROFEN XR relieves pain from inflammation associated with arthritis or physical overexertion, headaches including tension headache and mild to moderate migraine pain, minor aches and pain associated with muscles, joints, backache, aches and pain due to the common cold, relief of toothache and pain of dental extractions and menstrual pain, in addition to reducing fevers lasting for more than 6 hours.

Clinical studies show fast and long lasting pain relief for up to 12 hours.

What it does:

MAR-IBUPROFEN XR (Ibuprofen) is a non-steroidal anti-inflammatory drug (NSAID) that can reduce the chemicals produced by your body which cause pain and inflammation.

MAR-IBUPROFEN XR can only relieve pain and reduce swelling as long as you continue to take it.

When it should not be used:

Do not take MAR-IBUPROFEN XR if you have or are:

• active or recurrent stomach ulcer, gastrointestinal (GI) bleeding, or active inflammatory bowel disease (e.g. Crohn’s, colitis),
• taking acetylsalicylic acid (ASA) or any other NSAIDs including any other ibuprofen product,

• allergic/hypersensitive to ASA, ibuprofen, other salicylates, other NSAIDs or any of MAR-IBUPROFEN XR ingredients (Refer to the non-medicinal ingredients on outer carton or composition section),

  • nasal polyps (swelling of the inside of the nose), or allergic manifestations such as asthma, anaphylaxis (sudden severe life threatening allergic reaction), urticaria/hives, rhinitis (stuffed or runny nose that may be due to allergies), skin rash or other allergic symptoms,
  • dehydrated (significant fluid loss) due to vomiting, diarrhea or lack of fluid intake,
  • diagnosed with severe high blood pressure or have severe coronary artery disease,
  • right before or after heart surgery,
  • serious liver or kidney disease
  • Systemic Lupus Erythematosus,

  • or if you are in your third trimester of pregnancy.

MAR-IBUPROFEN XR should NOT be used in patients under 18 years of age since the safety and effectiveness have NOT been established.

What the medicinal ingredient is:

Ibuprofen

What the important nonmedicinal ingredients are:

Colloidal silicon Dioxide, Croscarmellose Sodium, Hydroxypropylmethyl cellulose, Maize starch, Microcrystalline cellulose, Sodium lauryl sulphate, Stearic acid.

Coating material ingredients: Opadry white (YS-1- 7040) contains Polyethylene Glycol Hydroxypropylmethyl cellulose, Talc, Titanium Dioxide

What dosage forms it comes in:

Each bi-layer tablet contains ibuprofen, 600 mg.

The first layer dissolves quickly to relieve pain fast. The second layer is time-released to give relief that lasts up to 12 hours. One MAR-IBUPROFEN XR tablet provides the same amount of medication as 200 mg of standard (immediate release) ibuprofen given every 4 hours.

ABOUT THIS MEDICATION

BEFORE you use MAR-IBUPROFEN XR talk to your doctor or pharmacist if:

• you have previous or current stomach ulcers, diabetes, high blood pressure, heart failure, heart disease or thyroid disease, asthma, kidney or liver disease, glaucoma, blood clotting disorder (such as hemophilia), any other serious disease, are under doctor’s care for any serious condition, you are trying to conceive, pregnant or breastfeeding or are taking any other drug including over the counter drugs.

Use with caution in the elderly.

Long-term continuous use may increase the risk of heart attack or stroke.

The use of NSAIDs, like Mar-Ibuprofen XR, in the second trimester of pregnancy should be restricted to the lowest dose necessary for the shortest possible duration.

At 20 weeks or later in pregnancy, your use of NSAIDs may need to be monitored by a doctor due to the rare risk of kidney problems in the unborn baby which may result in decreased amniotic fluid volume and other complications.

Stop use and ask a doctor if

• you show signs of stomach bleeding
• pain worsens or lasts more than 5 days
• fever worsens or lasts more than 3 days
• any new symptoms appear

Do not use this product if you are taking:

• Daily low dose ASA (81 – 325 mg), without talking to a doctor or pharmacist. Ibuprofen may interfere with the preventive benefits of ASA.
• ASA or other anti-inflammatory medication.

Talk to your doctor or pharmacist if you are taking other medication (prescription or non-prescription) such as any of the following (NOT a complete list):

acetaminophen, anticoagulants (blood thinners), digoxin, oral antidiabetic agents and insulin, diuretics, methotrexate, lithium, protein-bound drugs including probenecid, thyroxine, antibiotics, cyclosporine, phenytoin, corticosteroids or benzodiazepines, other NSAIDs, or medications for high blood pressure.

Usual dose:

Adults ≥ 18 years: Take 1 tablet every 12 hours as needed. Do not exceed 2 tablets in 24 hours, unless directed by a doctor. Do not use longer than 3 days for a fever or 5 days for pain relief. Do not take more than directed or more than 1 tablet at a time.

Do not crush, chew or dissolve the tablet.

INTERACTIONS WITH THIS MEDICATION

WARNINGS AND PRECAUTIONS

Serious Warnings and Precautions

• Caution in those with heart failure, high blood pressure or other conditions that may cause excess fluid collecting in tissues.
• Caution in patients at risk of gastrointestinal tract irritation, including those with a history of peptic ulcer. The chance of stomach bleeding is higher if you are: age 60 or older, have had stomach ulcers or bleeding problems, take a blood thinner or steroid drug, take with other drugs containing an NSAID like acetylsalicylic acid (ASA), ibuprofen, naproxen, or prescription anti- inflammatory drugs, have 3 or more alcoholic drinks every day while using this product.
• Caution in patients at risk of kidney problems, including the elderly or those using diuretics.
• Stop use immediately if you have difficulty or pain when urinating.
• Ibuprofen tablets should not be used during third trimester of pregnancy.
• Talk to your doctor if you are trying to conceive, in your first or second trimester of pregnancy or if breastfeeding.

PROPER USE OF THIS MEDICATION

Overdose:

Missed Dose:

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take your medicine and skip the missed dose. Do not take two doses at the same time.

Take with food or milk if upset stomach occurs. If abdominal pain, heartburn, nausea or vomiting, bloating diarrhea or constipation, ringing or buzzing in the ears, nervousness, sleeplessness, dizziness or any change in vision, itching, fluid retention, shortness of breath, wheezing, any trouble breathing or chest tightness, hives, swelling or itching, skin rashes, skin reddening, blisters, blood in vomit, bloody or black stools, jaundice (yellowing of the eyes or skin due to liver problem), or any other side effect or unexplained symptoms develop while taking MAR-IBUPROFEN XR, discontinue use immediately and contact a doctor.

Side effects may be minimized by using the smallest dose for the shortest duration of time.

This is not a complete list of side effects. For any unexpected effects while taking MAR-IBUPROFEN XR, contact your doctor or pharmacist.

In case of overdose, contact a Poison Control Centre or doctor immediately, even if there are no symptoms.

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

HOW TO STORE IT

Store in tightly closed container at room temperature (15°C-30°C).

Keep out of reach of children. This package contains enough medicine to seriously harm a child.

MORE INFORMATION

More information:

• Talk to your healthcare professional

• Find the full product monograph that is prepared for healthcare professionals and includes the Patient Medication Information by visiting the Health Canada Drug Product Database website (http://hc-sc.gc.ca/index-eng.php); the manufacturer’s website www.marcanpharma.com; or by calling 1‐855‐627‐2261.

  Date of Authorization: 2025-09-26

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting ( http://www.hc-sc.gc.ca/dhp-mps/medeff/report-declaration/index-eng.php) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.