Mar-Ranitidine: Uses, Side Effects and Dosage

Patient Medication Information: uses, side effects, how to take - Mar-Ranitidine

What the medication is used for:

What it does:

When it should not be used:

What the medicinal ingredient is:

What dosage form it comes in:

WARNINGS AND PRECAUTIONS

INTERACTIONS WITH THIS MEDICATION

PROPER USE OF THIS MEDICATION

Usual Adult dose:

Overdose:

HOW TO STORE IT

REPORTING SIDE EFFECTS

MORE INFORMATION

to heal ulcers in the stomach, or the part that
it empties into (the duodenum).
to prevent stomach ulcers which may be
caused by medicines called non-steroidal anti-inflammatory drugs (NSAIDs), often used to treat arthritis
to prevent ulcers from bleeding
to heal or stop problems caused by acid in
the food pipe (esophagus) or too much acid into the stomach. This can cause pain or discomfort sometimes known as indigestion or heartburn
to stop acid coming up from the stomach
while under anaesthetic during an operation

MAR-RANITIDINE belongs to a group of medicines called H₂-receptor blockers. It works by reducing the amount of acid in your stomach.

Don’t take MAR-RANITIDINE (ranitidine hydrochloride) tablets if you are allergic (hypersensitive) to ranitidine or any other ingredients in MAR-RANITIDINE(see What the nonmedicinal ingredients are).

Ranitidine hydrochloride

What the important nonmedicinal ingredients are: Castor oil, colloidal silicon dioxide, croscarmellose sodium, hydroxypropyl methyl cellulose, magnesium stearate, microcrystalline cellulose, talc and titanium dioxide.

MAR-RANITIDINE is available as tablets, 150 mg and 300 mg

Before you use MAR-RANITIDINE talk to your doctor or pharmacist if:

have stomach cancer
you have kidney disease, your doctor may lower your dose of Mar-Ranitidine
have a rare condition called acute porphyria
(a blood disease)
have lung disease
are diabetic
have any problems with immune system
have had stomach ulcers before and you are taking non-steroidal anti-inflammatory drugs (NSAIDs)
are taking any other medications including
NSAIDs (See Interactions with this Medication)

Under rare circumstances supervised by the doctor, H2 receptor antagonists such as ranitidine hydrochloride might be used for long periods. Long term use of H2 receptor antagonists may prevent normal absorption of vitamin B12 from the diet and could lead to vitamin B12 deficiency. Talk to your doctor.

Tell your doctor or pharmacist if you are taking any other medicines, if you’ve taken any recently, or if you start taking new ones. This includes medicines bought without a prescription. Some medicines can affect how MAR-RANITIDINE works, or make it more likely that you’ll have side effects. MAR-RANITIDINE can also affect how some other medicines work.

Drugs that may interact with MAR-RANITIDINE include:

Procainamide or N-acetylprocainamide
(used to treat heart problems)
warfarin (used to thin the blood)
Triazolam (used to treat insomnia)
Midazolam(a sedative that may be given just before an operation)
Ketoconazole (used to treat fungal infections)
Atazanavir Delaviridine (used to treat HIV)

Gefitnib (used to treat lung cancer)
Non-steroidal anti-inflammatory drugs
(NSAIDs) (used to treat pain and inflammation)
Sucralfate (used to treat ulcers). Your doctor
may advise that you take high doses or oral sucralfate (e.g. 2g) at least 2 hours after MAR-RANITIDINE administration.

Always take MAR-RANITIDINE exactly as your doctor has told you to. Check with your doctor or pharmacist if you are not sure.

The usual dose is either:

150 mg in the morning and 150 mg in the
evening or,
300 mg at bedtime

Your exact dose will depend on your particular stomach condition. Your doctor will tell you the dose you should take.

Swallow each tablet whole with some water.

If you take too much MAR-RANITIDINE, contact your doctor or pharmacist for advice. If possible, show them the MAR-RANITIDINE pack.

In the event of overdose, contact a health care practitioner, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

SIDE EFFECTS AND WHAT TO DO WITH THEM

Side effects may include:

allergic reactions
skin rash
inflammation of blood vessels (vasculitis)
inflammation of the pancreas (pancreatitis)
inflammation of the liver (hepatitis),
sometimes with yellowing of the eyes or skin (jaundice)
inflammation of the kidney (interstitial
nephritis)
slow, fast or irregular heartbeat
- diarrhea, constipation, nausea, vomiting, stomach pain
- feeling confused, depressed, or excited, or seeing, or hearing things that are not really there (hallucinations), trouble sleeping (insomnia); feeling sleepy (somnolence)
- joint or muscle pain, malaise, uncontrolled movement
- headache, dizziness, blurred vision
- unusual hair loss or thinning (alopecia)
- unable to get or maintain an erection
  (impotence)
- unusal secretion of breast milk or breast enlargement in men

If you have any concerns about side effects, tell your doctor, nurse or pharmacist.

Side effects that may show up in blood tests:

change to liver function
low levels of white blood cells
decrease in number of blood platelets (cells that help blood to clot)
decrease in number of all types of blood cells
small increase in the level of creatinine (a waste product) in your blood.

	SERIOUS SIDE EFFECTS, HOW OFTEN THEY HAPPEN
	AND WHAT TO DO ABOUT THEM
Symptom / effect Hepatitis Yellowing of the skin or whites of the eyes, dark or tea coloured urine, pale coloured stools/bowel movements, nausea/vomiting, loss of appetite, pain, aching or tenderness on right side below the ribs Cardiovascular Slow, fast or irregular heartbeat		Talk with your doctor or pharmacist		Stop taking drug and call your doctor or pharmacist
		Only if severe	In all cases
					✓
					✓

This is not a complete list of side effects. For any unexpected effects while taking MAR-RANITIDINE, contact your doctor or pharmacist.

Store between 15°C and 30°C. Protect from light and moisture. Do not store in the bathroom. Keep MAR- RANITIDINE out of the reach of children.

You can help improve the safe use of health products for Canadians by reporting serious and unexpected side effects to Health Canada. Your report may help to identify new side effects and change the product safety information.

3 ways to report:

------------------------------------------------------------

Online at MedEffect (http://hc-sc.gc.ca/dhp-mps/medeff/index-eng.php);
By calling 1-866-234-2345 (toll-free)
- By completing a Consumer Side Effects
  Reporting Form and sending it by:
  - Fax to 1-866-678-6789 (toll-free), or
  - Mail to: Canada Vigilance Program
    Health Canada,
    Postal Locator 0701E Ottawa, ON K1A 0K9

Postage paid labels and the Consumer Side Effect Reporting Form are available at MedEffect (http://hc-sc.gc.ca/dhp-mps/medeff/index-eng.php). .

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

This document plus the full product monograph, prepared for health professionals can be obtained by contacting the sponsor, Marcan Pharmaceuticals Inc., at: 1-613-228-2600

Marcan Pharmaceuticals Inc.

77 Auriga Drive, Unit 4

Ottawa, ON K2E 7Z7

Date of Preparation: April 25, 2016

SERIOUS SIDE EFFECTS, HOW OFTEN THEY HAPPEN

AND WHAT TO DO ABOUT THEM

Symptom / effect

Talk with your doctor or pharmacist

Stop taking drug and call your doctor or pharmacist

Only if severe

In all cases

Hypersensitivity
Reaction raised and itchy rash (hives), swelling sometimes of the face or mouth (angioedema), chest pain, shortness of breath, unexplained fever, wheezing, or difficulty in breathing, feeling faint,
especially, when
standing up, collapse

Serious skin Reactions Skin rash, which may blister, and look like small targets (central dark spots surrounded by a paler area, with a dark ring around the edge)