Patient Medication Information: uses, side effects, how to take - Midamor
Serious warnings and precautions box
What MIDAMOR is used for:
MIDAMOR is used:
- alone or with other diuretics to treat adults with liver disease who have swelling caused by a build-up of fluid in the belly (ascites) and in the tissues (edema).
with other diuretics to treat:
- swelling caused by a build up of fluid in the tissues due to heart problems or
- high blood pressure (hypertension) in adults who have low levels of potassium in their blood (hypokalemia) or who need to maintain normal levels of potassium.
MIDAMOR may cause high levels of potassium in your blood (hyperkalemia) when taken alone or with diuretics. This may be more likely to happen if you:
Your healthcare professional will perform check-ups and tests to monitor the levels of potassium in your blood. Talk to your healthcare professional right away if you have:
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How MIDAMOR works:
MIDAMOR is a potassium conserving drug (antikaliuretic drug). It helps the body lose excess salt but keep a normal amount of potassium (an electrolyte) in the blood.
The ingredients in MIDAMOR are:
Medicinal ingredients: Amiloride hydrochloride
Non-medicinal ingredients: Croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline cellulose and yellow ferric oxide.
MIDAMOR comes in the following dosage form(s):
Tablets: 5 mg
Do not use MIDAMOR if:
- you are allergic to amiloride hydrochloride or any of the other ingredients in MIDAMOR.
- you have high levels of potassium levels in the blood.
- you are taking any other potassium conserving drugs or potassium supplements.
- you have difficulty urinating or produce no urine (anuria).
- you have kidney failure, severe or
- you have worsening kidney disease or problems with your kidneys because of diabetes (diabetic nephropathy).
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take MIDAMOR. Talk about any health conditions or problems you may have, including if you:
- have diabetes.
- have liver, heart or kidney problems.
- have cardiopulmonary disease (disease involving both the lungs and heart).
- are taking other diuretics or “water pills”.
- have low sodium and chloride levels in your blood.
- have high blood urea nitrogen (BUN) levels.
- have high creatinine levels in blood.
- have lactose intolerance.
- are pregnant or planning to become pregnant.
- are breastfeeding.
- are 65 years of age or older.
Other warnings you should know about:
Pregnancy: It is not known if MIDAMOR can harm an unborn baby. Tell your healthcare professional if you are pregnant or think you may be pregnant before your treatment with MIDAMOR. You and your healthcare professional will decide if you should be given MIDAMOR during pregnancy.
Breastfeeding: It is not known if MIDAMOR passes into breast milk and may harm your baby. Your healthcare professional will decide if you should stop breastfeeding or stop taking MIDAMOR.
Check-ups and testing: While you are taking MIDAMOR, your healthcare professional will do check-ups and tests to monitor:
- the level of electrolytes (such as potassium), creatine and urea nitrogen in your blood
- acid-base balance
- health of your kidneys
Driving and using machines: MIDAMOR can cause low blood pressure, dizziness, weakness, sleepiness and problems with your vision. Do not drive a car or do other tasks that require special attention if you feel any of these effects.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
Serious drug interactions:
Do not take MIDAMOR with:
Taking MIDAMOR with any of these medicines may cause serious drug interactions. Ask your healthcare professional if you are unsure you are taking these medicines. |
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The following may also interact with MIDAMOR:
- lithium used to treat bipolar disease.
- angiotensin-converting-enzyme inhibitors used to treat high blood pressure and heart failure.
- cyclosporine or tacrolimus used to suppress the body’s immune response, or prevent organ transplant rejection.
How to take MIDAMOR:
- Take MIDAMOR exactly as your healthcare professional tells you. Talk to your healthcare professional if you are not sure.
- It is recommended to take your dose at the same time every day.
Usual dose:
Your healthcare professional will determine the dose that is right for you. Your dose will depend on how much potassium is in your blood and other diuretics you are taking.
To treat swelling in adults with liver disease: 1 tablet (5 mg) per day. Do not take more than 4 tablets (20 mg) in a day.
To treat swelling in adults with heart problems: 1 or 2 tablets per day or in divided doses. Do not take more than 4 tablets (20 mg) a day.
To treat high blood pressure in adults: 1 or 2 tablets per day or in divided doses. Do not take 4 tablets (20 mg) a day.
Overdose:
Signs of an overdose may include:
- dehydration
- electrolyte imbalance
| If you think you, or a person you are caring for, have taken too much MIDAMOR, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms. |
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Missed dose:
If you forget to take MIDAMOR, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do NOT take a double dose to make up for the missed dose.
Possible side effects from using MIDAMOR:
These are not all the possible side effects you may have when taking MIDAMOR. If you experience any side effects not listed here, tell your healthcare professional.
Side effects may include:
- nausea
- loss or change in appetite
- diarrhea
- vomiting
- headache
- abdominal pain
- gas pain
- constipation
- weakness
- tiredness
- muscle cramps and pain
- dizziness or spinning sensation
- brain disease
- difficulty in getting and keeping an erection, change in libido
- cough
- shortness of breath
- dry mouth, thirst
- numbness and tingling
- hearing problems (ringing in the ears)
- confusion
- difficult sleeping (insomnia)
- drowsiness
- shakiness (tremors)
- nervousness
- stuffy nose
- problems with your vision
Serious side effects and what to do about them
| Frequency/Side Effect/Symptom | Talk to your healthcare professional | Stop taking this drug and get immediate medical help | |
|---|---|---|---|
| Frequency/Side Effect/Symptom | Talk to your healthcare professional | Stop taking this drug and get immediate medical help | |
| Only if severe | In all cases | ||
| Only if severe | In all cases | ||
| Common | |||
| Encephalopathy (disease or disorder of the brain): confusion or disorientation, trouble thinking, memory loss, changes in personality | √ | ||
| Hyperkalemia (high level of potassium in the blood): muscle weakness, abnormal or slow heart rhythms, significant tingling and muscle contraction, paralysis | √ | ||
| Rare | |||
| Dysuria: pain or burning sensation during urination | √ | ||
| Gastrointestinal (GI) bleeding: (bleeding anywhere along the GI tract between mouth and anus): blood in vomit, black tarry stool, bright red blood in your stool or coming from rectum, rapid pulse, low blood pressure, low urine flow, confusion, weakness, dizziness | √ | ||
| Heart problems: fast or irregular heartbeat, palpitations, chest pain, difficulty breathing, fainting | √ | ||
| Hypotension (low blood pressure): dizziness, fainting, light-headedness, blurred vision, nausea, vomiting, fatigue (may occur when you go from lying or sitting to standing up) | √ | ||
| Increased intraocular pressure (pressure in the eye) | √ | ||
| Jaundice (build up of bilirubin in the blood): yellowing of the skin and eyes, dark urine, light coloured stool, itching all over your body | √ | ||
| Musculoskeletal pain (pain that affects the muscles and tendons along with bones): muscle pain, limb pain, joint pain and bone pain | √ | ||
| Skin rash, itching, loss of hair | √ | ||
| Unknown | |||
| Aplastic anemia (when cells meant to develop into mature blood cells are damaged): fatigue, weakness, pale skin | √ | ||
| Hyperuricemia (high uric acid levels in the blood): intense pain, joint stiffness, redness and swelling | √ | ||
| Hyponatremia (low sodium in the blood): lethargy, confusion, muscular twitching, achy, stiff or uncoordinated muscles, seizure, coma | √ | ||
| Neutropenia (decreased white blood cells): infections, fatigue, fever, aches, pains and flu-like symptoms | √ | ||
| Peptic ulcer: dull or burning stomach pain, heartburn, feeling of fullness or bloating, nausea | √ | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
Store at room temperature (15°C to 30°C).
Keep out of reach and sight of children.
If you want more information about MIDAMOR:
- Talk to your healthcare professional
Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada Drug Product Database website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-
- product-database.html); the manufacturer’s website http://www.aapharma.ca/en/, or by calling 1-877-998-9097.
Date of Authorization: 2025-06-10