Patient Medication Information: uses, side effects, how to take - Persantine Tab 50mg
ABOUT THIS MEDICATION
What the medication is used for:
Persantine tablets are indicated for the prevention of blood clot complications that can occur after prosthetic heart valve surgery.
What it does:
Persantine dilates the blood vessels of the heart muscle and regulates increased blood cell tendency to stick together. It works by preventing excessive blood clotting.
When it should not be used:
Persantine should not be used by patients with allergic reactions to dipyridamole or any component of the drug.
What the medicinal ingredient is:
Dipyridamole
What the important nonmedicinal ingredients are:
Acacia, calcium hydrogen phosphate, carnauba wax, colloidal silica, FDC yellow, magnesium stearate, polyethylene glycol, starch, sucrose, talc, titanium dioxide, white wax, and red iron oxide.
What dosage forms it comes in:
Persantine comes as a tablet to take by mouth. Tablets are 50 mg or 75 mg.
WARNINGS AND PRECAUTIONS
BEFORE you use Persantine talk to your doctor or pharmacist:
$ If you are allergic to dipyridamole or any other drug. $ If you are taking any other prescription or non
prescription drugs, especially aspirin (ASA). $ If you have or ever had any heart problems, a low blood
pressure or history of breathing problems. $ If you are pregnant, plan to become pregnant, or are
breast-feeding. If you become pregnant while taking Persantine, call you doctor.
$ If you are having surgery, including dental surgery, tell
the doctor or dentist you are taking Persantine.
Worsening of symptoms of heart disease have been observed in some patients.
INTERACTIONS WITH THIS MEDICATION
Drugs that may interact with Persantine include: Adenosine, other drugs that prevent blood clotting, blood pressure lowering drugs, and cholinesterase inhibitors.
PROPER USE OF THIS MEDICATION
Usual dose:
The usual dose is 100 mg taken four times daily, one hour before meals.
Sometimes a lower dose of 100 mg daily Persantine is taken together with 1.0 g of acetylsalicylic acid (ASA). Follow the directions given by your doctor carefully, and ask your doctor or pharmacist if you have any questions.
Overdose:
In case of overdose call you doctor immediately or call 911.
Missed Dose:
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
SIDE EFFECTS AND WHAT TO DO ABOUT THEM
Side effects from Persantine at prescribed doses are usually minimal and transient. Mild occasional stomach upset can be avoided by taking the tablets with glass of milk. Tell your doctor if any of these symptoms are severe or do not go away after a while: dizziness, stomach pain, headache, rash, diarrhoea, vomiting, feeling warmth, or weakness. If you experience any of the following call your doctor immediately: unusual bleeding or bruising, chest pain, increased heart rate, low blood pressure, or allergic reactions - difficulty breathing, severe bronchospasm or edema.
On rare occasions, when side effects have been persistent or intolerable stopping the medication has resolved the undesirable side effects. Do not stop taking the tablets without talking to your doctor.
| Symptom / effect | Talk with your doctor or pharmacist | |
| Only if severe or persistent | Call immediately in all cases | |
| Dizziness, stomach pain, headache, rash, diarrhoea, vomiting, feeling warmth, weakness. | T | |
| Unusual bleeding or bruising, chest pain, increased heart rate, low blood pressure, allergic reaction (difficulty breathing, severe bronchospasm or edema). | T | |
This is not a complete list of side effects. For any unexpected effects while taking Persantine, contact your doctor or
Product Monograph Page 22 of 22 pharmacist.
HOW TO STORE IT
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature (15 – 30°C) and away from excess heat and moisture (not in the bathroom). Protect from light and freezing.
Do not let anyone else take your medication.
REPORTING SUSPECTED SIDE EFFECTS
To monitor drug safety, Health Canada collects information on serious and unexpected effects of drugs . If you suspect you have had a serious or unexpected reaction to this drug you may notify Health Canada by:
toll-free telephone: 866-234-2345 toll-free fax: 866-678-6789
By email: cadrmp@hc-sc.gc.ca
By regular mail:
National AR Centre
Marketed Health Products Safety and Effectiveness Information Division
Marketed Health Products Directorate
Tunney’s Pasture, AL 0701C
Ottawa ON K1A 0K9
NOTE: Before contacting Health Canada, you should contact your physician or pharmacist.
MORE INFORMATION
This document plus the full product monograph, prepared for health professionals can be found at:
http://www.boehringer-ingelheim.ca
or by contacting the sponsor, Boehringer Ingelheim Canada Ltd., at:1-800-263-5103, ext. 4633 (Medical Information)