Patient Medication Information: uses, side effects, how to take - PMS-Pantoprazole (Pharmascience, 40 mg)
What is pms-PANTOPRAZOLE used for?
pms-PANTOPRAZOLE is used to treat stomach acid-related problems such as:
- Reflux esophagitis This is a severe form of heartburn
- Pathological hypersecretory conditions (e.g., Zollinger-Ellison syndrome). These are conditions in which the stomach produces too much acid.
pms-PANTOPRAZOLE is administered:
- mainly in hospitals.
- when you cannot take oral medicines.
- for short-term use (up to 7 days)
How does pms-PANTOPRAZOLE work?
pms-PANTOPRAZOLE is a proton pump inhibitor. It reduces the amount of acid your stomach makes. By reducing the acid, pms-PANTOPRAZOLE reduces the symptoms (e.g., heartburn).
What are the ingredients in pms-PANTOPRAZOLE?
Medicinal ingredients: Pantoprazole Sodium Sesquihydrate
Non-medicinal ingredients: Sodium Hydroxide and Water
pms-PANTOPRAZOLE comes in the following dosage forms:
- Powder for injection: 40 mg pantoprazole (as pantoprazole sodium sesquihydrate) per vial
Your healthcare professional may switch you to pantoprazole tablets. This may occur as soon as you can start taking oral medicines again.
Do not use pms-PANTOPRAZOLE if:
- You are allergic to any of its ingredients (see What are the ingredients in pms-PANTOPRAZOLE).
- You are taking rilpivirine
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take pms-PANTOPRAZOLE. Talk about any health conditions or problems you may have, including if you:
- are taking other medications (see The following may interact with pms-PANTOPRAZOLE)
are pregnant or plan to become pregnant.
- are breastfeeding or plan to breastfeed. Pantoprazole has been found in human breast milk. Talk with your doctor.
- have had any past problems with the amount of zinc in your blood.
suffer these effects:
- severe or persistent diarrhea;
- repeated vomiting;
- vomiting blood;
- dark stools;
- tiredness (anemia);
- difficulty in swallowing.
have low magnesium in the body, which may cause symptoms such as:
- rapid heartbeat;
- dizziness, seizures;
- muscle cramping, twitching or spasms.
- are due to have a specific blood test (Chromogranin A).
Other warnings you should know about:
You will use the lowest dose and shortest time suitable for your condition. Talk to your doctor if you have any concerns about your treatment.
Depending on your condition, your doctor may tell you to use this type of medicine (proton pump inhibitors) for a longer period.
Using proton pump inhibitors for a long time (every day for a year or longer) may increase risks of broken bones of the hip, wrist or spine. Talk to your doctor about this risk.
Long term use of proton pump inhibitors may interfere with the absorption of Vitamin B12 from the diet. This may cause a shortage of Vitamin B12 in your body. Talk to your doctor.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with pms-PANTOPRAZOLE:
Warfarin, atazanavir, nelfinavir, saquinavir/ritonavir, methotrexate.
How to take pms-PANTOPRAZOLE:
Your doctor or nurse will administer pms-PANTOPRAZOLE.
Usual dose:
Your doctor will decide the dose of pms-PANTOPRAZOLE for your condition.
The recommended doses are:
| Condition | Adult Dose | How Often |
| Reflux Esophagitis | 40 mg | Once daily |
| Hypersecretory conditions. This includes Zollinger-Ellison Syndrome. | 80 mg | Every 12 hours |
Overdose:
| If you think you have taken too much pms-PANTOPRAZOLE, contact your healthcare professional, hospital emergency department or regional Poison Control Center immediately, even if there are no symptoms. |
Missed Dose:
Contact your healthcare professional if you feel your doctor or nurse has missed a dose.
What are possible side effects from using pms-PANTOPRAZOLE?
Like all medicines, pms-PANTOPRAZOLE may cause side effects. Side effects have generally been mild and did not last a long time. These are not all the possible side effects you may feel when taking pms-PANTOPRAZOLE.
The most common side effects are:
- headache
- diarrhea
- nausea/vomiting
- general stomach discomfort
Less often the following can occur:
- swelling or bruising at the injection site
- itchiness
- rash
Tell your doctor right away if you have any of these symptoms:
- new or worsening joint pain
- rash on your cheeks or arms that gets worse in the sun
Your symptoms may get worse after stopping your medication. This may occur as your stomach may increase the production of acid.
Serious Side Effects and What to do About Them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |||
|---|---|---|---|---|---|
| Only if severe | In all cases | ||||
| Rare | Disturbances in vision. Most cases reported are not serious. | √ | |||
| Isolated cases | Liver damage. Symptoms include a yellow tinge to the skin and eyes. | √ | |||
| Serious skin reactions. Symptoms include widespread rash, itching, or hives. Peeling of the skin, blisters on the skin, mouth, nose, eyes and genitals are other symptoms. | √ | ||||
| Muscle wasting | √ | ||||
| Clostridium difficile colitis. Symptoms include severe (watery or bloody) diarrhea, fever, and abdominal pain or tenderness. | √ | ||||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
The healthcare professional will store the product appropriately. Store between 15ºC and 30ºC and protect from light. Keep out of reach and sight of children.
If you want more information about pms-PANTOPRAZOLE:
Talk to your healthcare professional
Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website
- (http://www.hc-sc.gc.ca/); the manufacturer’s website www.pharmascience.com, or by calling 1-888-550-6060
Pharmascience Inc.
Montréal, Québec, H4P 2T4
www.pharmascience.com