Patient Medication Information: uses, side effects, how to take - Solystat (Pendopharm Division of Pharmascience, 1 G, 250 mg)
ABOUT THIS MEDICATION
What the medication is used for:
SOLYSTAT is used to remove high amounts of potassium from the blood.
What it does:
SOLYSTAT attaches to the extra potassium in the body, particularly in the large intestine, so it can be removed from the body in the stool.
When it should not be used:
Do not take SOLYSTAT if:
- You have a bowel obstruction (blocked intestine).
- You have low levels of potassium in your blood.
- If you are allergic to sodium polystyrene sulfonate
Do not use SOLYSTAT in newborn babies who have slowed movements in their gut (caused by other medications or following surgery).
Do not give SOLYSTAT by mouth to newborn babies. SOLYSTAT should only be given rectally to newborns.
What the medicinal ingredient is:
Sodium polystyrene sulfonate
What the non-medicinal ingredients are:
Powder for suspension: None
Oral suspension: Sorbitol, methylparaben, propylparaben
What dosage forms it comes in:
- Powder for suspension (for oral or rectal use)
- Oral suspension (for oral use)
WARNINGS AND PRECAUTIONS
BEFORE you use SOLYSTAT, talk to your doctor, nurse or pharmacist if you have or have had any medical conditions, especially the following:
- Heart problems
- High blood pressure
- Problems with your bowel movements such as delayed bowel movements or constipation
- Severe burns
- Low blood volume, which can occur with dehydration or bleeding
- Have been told you have an electrolyte imbalance. SOLYSTAT therapy can worsen these imbalances. Your doctor may want to check the levels of the electrolytes in your blood more frequently during treatment.
- Are undergoing dialysis or have any kidney problems
- Edema (swelling of the face, hands or feet with fluid)
- You require low salt diet.
You are pregnant, think you are pregnant, or intend to become pregnant.
- You are breastfeeding. It is not known if SOLYSTAT passes into breast milk.
- You are taking a sweetener called sorbitol (a «sugar-free» sweetener used to sweeten food).
- You have problems with your bowel, bowel movements or delayed bowel movements (constipation) caused by drugs or following a surgery.
When taken by mouth, avoid taking SOLYSTAT at the same time as other orally administered medications (see “PROPER USE OF THIS MEDICATION”).
Magnesium containing laxatives should not be used with SOLYSTAT.
INTERACTIONS WITH THIS MEDICATION
As with most medicines, interactions with other drugs are possible. Tell your doctor, nurse or pharmacist about all the medicines you take, including drugs prescribed by other doctors, vitamins, minerals, natural supplements or alternative medicines (non-prescription drugs or over the counter drugs).
When taken by mouth, SOLYSTAT may interfere with how other oral medicines are absorbed (see “PROPER USE OF THIS MEDICATION”).
IMPORTANT: PLEASE READ
The following may interact with SOLYSTAT:
- Digoxin, a medicine used for heart problems.
- Laxatives such as magnesium hydroxide or aluminum carbonate
- Thyroxine, a medicine for hypothyroidism
- Lithium, a medicine which can be used to treat bipolar disorder.
- Antacids containing aluminum or magnesium
- Sorbitol (a ‘sugar free’ sweetener used to sweeten food).
- Immunosuppressant drugs
- Drugs that slow the stomach from emptying (drugs such as anticholinergics or narcotics)
PROPER USE OF THIS MEDICATION
Usual dose:
SOLYSTAT Powder for Suspension can be given by mouth or in the rectum.
SOLYSTAT Oral Suspension is given only by mouth.
The amount of SOLYSTAT you need to take will depend upon the amount of potassium in your blood.
Once the mixture of SOLYSTAT Powder for Suspension has been prepared, it should be used straight away. If it needs to be stored, it should be stored for no longer than 24 hours. Do not heat SOLYSTAT.
Your doctor will decide exactly how much SOLYSTAT you need to take. The usual doses are:
ORAL DOSING
When taken by mouth, SOLYSTAT should be taken at least 3 hours before or 3 hours after other oral medications. For patients with gastroparesis (a condition preventing your stomach from emptying properly), a 6-hour separation should be considered. Consult your health care provider for recommendations (see “WARNINGS AND PRECAUTIONS” and “INTERACTIONS WITH THIS MEDICATION”).
SOLYSTAT Powder for Suspension is usually given by mouth mixed in a small amount of water. It can also be mixed with food or sweetened liquid. Do NOT mix SOLYSTAT with orange juice or fruit juice which contains potassium.
- SOLYSTAT Oral Suspension does not require any preparation before use. Shake the bottle well before drinking.
Be careful not to inhale SOLYSTAT Powder for Suspension accidentally. Breathing in the powder may cause coughing and shortness of breath.
Your doctor will regularly check the potassium, calcium and magnesium levels in your blood. The doctor may change the dose or stop the SOLYSTAT depending on what the results of these blood tests are.
Adults, including the elderly:
- SOLYSTAT Powder for Suspension: 15 grams (about 4 level teaspoons) one to four times daily as indicated above.
- SOLYSTAT Oral Suspension: 15 grams (60 mL) one to four times daily as indicated above.
Children:
You should follow the dosing recommended by your doctor.
For children, SOLYSTAT Powder for Suspension is preferably given with a drink (NOT a fruit juice because of the high potassium content) or a little jam or honey.
Newborn babies (neonates)
SOLYSTAT should not be given by mouth.
RECTAL DOSING
Rectal dosing only applies to SOLYSTAT Powder for Suspension. The enema is usually given by a doctor or nurse.
Adults:
Children and newborn babies (neonates):
IMPORTANT: PLEASE READ
Overdose:
Taking too much SOLYSTAT may reduce your potassium in your blood below the normal level. If you take too much of this medication, you may feel irritable, confused, have muscle weakness, have diminished reflexes or paralysis.
If you think you, or a person you are caring for, have taken too much SOLYSTAT, contact a healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.
Missed Dose:
Do not take a double dose to make up for the dose you have missed. If it is almost time for the dose, skip the dose you missed and take the next dose when you are meant to.
SIDE EFFECTS AND WHAT TO DO ABOUT THEM
These are not all the possible side effects you may have when taking SOLYSTAT. If you experience any side effects not listed here, tell your healthcare professional
Side effects may include:
- Nausea and vomiting
- Diarrhea
- Loss of appetite
| SERIOUS SIDE EFFECTS, AND WHAT TO DO ABOUT THEM | ||||||
|---|---|---|---|---|---|---|
| Symptom / effect | Talk with your healthcare professional | Stop taking drug and get immediate medical help | ||||
| Only if severe | In all cases | |||||
| UNKNOWN FREQUENCY | ||||||
| Constipation: bloating and swelling of the abdomen. | x | |||||
| Abdominal pain (pain in your stomach and rectum) | x | |||||
| Stomach irritation and bleeding: vomit that looks like coffee grounds. | x | |||||
| Rectal bleeding: | x | |||||
| black bloody or tarry stools. | |||
|---|---|---|---|
| Allergic reaction: difficulty swallowing or breathing, wheezing, feeling sick to your stomach and throwing up, hives or rash, swelling of the face, lips, tongue or throat. | x | ||
| Hypernatremia (high level of sodium:(swelling | x | ||
| Hypokalemia (low level of potassium in the blood): muscle weakness, muscle spasms, cramping, constipation, feeling of skipped heart beats or palpitations, fatigue, tingling or numbness. | x | ||
| Hypocalcemia (low level of calcium): feeling nervous or unable to relax, having fits, or muscle cramps. | x | ||
| Fecal impaction (blocked colon from a mass of stool) following rectal administration, particularly in children: abdominal pain, nausea and vomiting, liquid stool, urge to move bowels, loss of appetite, weight loss, malaise | x | ||
| Bowel obstruction or gastrointestinal stenosis (the bowel or part of the gastrointestinal tract is partially or fully blocked): cramping, severe stomach pain, | x | ||
IMPORTANT: PLEASE READ
| vomiting, bloating, constipation, inability to pass stool or gas, loss of appetite, swelling of the abdomen. | |||
|---|---|---|---|
| Gastrointestinal necrosis and bowel perforation: severe stomach pain, chills, fever, nausea vomiting, bleeding from your rectum, swelling of the stomach, constipation, diarrhea, fever fainting, low uring and confusion | x | ||
| Gastrointestinal Ischemia / Ischemic Colitis (slow or no blood flow to the intestines): abdominal cramps, abdominal pain, bright red bowel movement, weight loss, diarrhea, nausea bloating. | x | ||
Peritonitis (swelling of the lining of the belly or stomach): abdominal pain or tenderness, bloating, fever, nausea and vomiting, loss of appetite, diarrhea, thirst, low urine, cannot pass stool or gas, fatigue, confusion. | x | ||
| Gastrointestinal Necrosis | |||
This is not a complete list of side effects. For any unexpected effects while taking SOLYSTAT, contact your doctor or pharmacist.
HOW TO STORE IT
Powder for Suspension
Store between 15°C and 30°C. Store in a well-closed container. Keep out of reach and sight of children.
Oral Suspension
Store between 15°C and 30°C. Store in a well-closed container. Protect from freezing and from excessive heat. Keep out of reach and sight of children.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
|---|
MORE INFORMATION
If you want more information about SOLYSTAT:
- Talk to your healthcare professional
- Find the full Prescribing Information that is prepared for healthcare professionals and includes this Consumer Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website (www.pendopharm.com); or by calling 1-888-550-6060.
Last revised: December 5, 2024
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