Patient Medication Information: uses, side effects, how to take - Suprane
Serious Warnings and Precautions
Your healthcare professional will monitor you and will take care of you if this happens. |
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What is SUPRANE used for?
SUPRANE is used to keep patients asleep during surgery (general anesthesia). SUPRANE is used in:
- adults who have been put to sleep using another anesthetic.
- children who have been put to sleep using another anesthetic and are intubated (a tube is put down the throat to help you breathe).
How does SUPRANE work?
SUPRANE contains the medicinal ingredient desflurane which belongs to a group of medicines called general anesthetics. Desflurane is a liquid that becomes a gas when put into a special machine. This gas mixes with the oxygen you will be breathing in during surgery. Desflurane works by temporarily reducing the activity of the body’s central nervous system. This causes a loss of consciousness, muscle relaxation and loss of sensation.
What are the ingredients in SUPRANE?
Medicinal ingredients: Desflurane
Non-medicinal ingredients: None.
SUPRANE comes in the following dosage forms:
volatile liquid; 100% v/v
Do not use SUPRANE if:
- you/your child have been told that you/they are allergic to desflurane or other inhaled general anesthetics
- you/your child have a history of liver inflammation (hepatitis) liver problems, jaundice (yellowing of the skin or eyes), unexplained fever or certain types of inflammation reactions after having general anesthetic medicines.
- you/your child or a family member have had malignant hyperthermia (a serious, sometimes deadly, reaction to anesthesia where your body temperature becomes dangerously high and your muscles contract)
- you/your child have been told you should not receive general anesthesia.
it is used to put children to sleep as it can cause beathing problems including:
- coughing,
- holding breath,
- stop breathing for short periods during your normal nightly sleep,
- spasm in the vocal cord that makes it difficult to speak or breathe
- increased mucus.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you/your child are given SUPRANE. Talk about any health conditions or problems you/your child may have, including if you/your child:
are pregnant or think you might be pregnant.
- are breast-feeding or are planning to breastfeed.
- have previously had general anesthesia, particularly if repeated over a short period of time.
- have liver or kidney problems.
- have asthma or have recently had an upper airway infection.
- have heart problems, heart rhythm problems, or are taking medication that may cause heart rhythm problems.
- have diabetes.
- have a tumor that develops in the adrenal gland (pheochromocytoma).
- have cancer.
- have a neuromuscular disease such as Duchenne Muscular Dystrophy.
- are 65 years of age or older.
Other warnings you should know about:
Once you/your child have stopped receiving SUPRANE you/your child should regain consciousness within minutes. Like with other anesthetics, you/your child might notice small changes in your/their mood. This might last for several days after you/your child have had SUPRANE. Talk to your/your child’s healthcare professional is this becomes severe.
Driving and using machines: Give yourself/your child time after being given SUPRANE to see how you/they feel before driving a vehicle or using machines. After receiving SUPRANE, it may take at least 24 hours for you/your child to become fully alert.
Monitoring: Your/your child’s healthcare professional will monitor your/your child’s health while you/they receive SUPRANE. Your/your child’s healthcare professional will monitor your/their:
- blood pressure
- heart rate
- breathing
Tell your/your child’s healthcare professional about all the medicines you/your child take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
Serious Drug Interactions If you/your child have muscular disease such as Duchenne Muscular Dystrophy, taking SUPRANE and succinylcholine may cause an increase of blood potassium levels and heart rhythm problems. |
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The following may interact with SUPRANE:
- other anesthetics
- midazolam, used to induce sedation and relieve anxiety and muscle tension
- opioid medicines, such as fentanyl (used to treat severe pain)
- nitrous oxide
- muscle relaxants
- beta blockers, used to treat high blood pressure and heart problems
- monoamine oxidase inhibitors, used to treat depression, anxiety and migraines
- amphetamines, used to speed up the body’s system
- psychostimulants, used to increase alertness, attention and energy
- medicines used to suppress appetite
- ephedrine, use to treat low blood pressure
- isoniazid, an antibiotic used to treat tuberculosis
alcohol
How to take SUPRANE:
- Before being given SUPRANE, you/your child will be given another anesthetic to make you/them go to sleep.
- SUPRANE is administered by inhalation and is given to you/your child by a healthcare professional.
Usual dose:
Your/your child’s healthcare professional will decide what dose of SUPRANE you/your child will receive. The dose will vary depending on your/your child’s age, weight, and the type of operation that you/your child are having.
Overdose:
| SUPRANE is given to you/your child by a healthcare professional. The healthcare professional will care for you/your child in the event of an overdose. |
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What are possible side effects from using SUPRANE?
These are not all the possible side effects you/your child may have after being given SUPRANE. If you/your child experience any side effects not listed here, tell your/your child’s healthcare professional.
Side effects when you/your child wake up may include:
- headache
- cough
- nausea
- vomiting
- excessive production of saliva
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| COMMON | |||
Breathing problems: Difficulty breathing/choking/shortness of breath, wheezing | ✓ | ||
| Heart rate problems: change in heartbeat (slow, rapid or irregular heartbeat) | ✓ | ||
| Hypertension (high blood pressure): shortness of breath, fatigue, dizziness or fainting, chest pain or pressure, swelling in your ankles and legs, bluish colour to your lips and skin, racing pulse or heart palpitations | ✓ | ||
| Inflammation of pharynx (back of the throat): sore throat | ✓ | ||
| UNCOMMON | |||
| Agitation: excitement, nervousness, an urge to move | ✓ | ||
| Dizziness | ✓ | ||
| Hemorrhage (bleeding disorders): bruising, bleeding, vomiting or | ✓ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| coughing blood, fatigue and weakness | |||
| Hyperkalemia (high level of potassium in the blood): muscle weakness, abnormal heart rhythms | ✓ | ||
| Hypoxia (decreased oxygen in your blood): shortness of breath, bluish colour to lips or fingers. | ✓ | ||
| Myalgia (severe muscle pain): aching muscles, tenderness or weakness that you can’t explain | ✓ | ||
| Myocardial infarction (heart attack): pressure or squeezing pain in the chest, jaw, left arm, between the shoulder blades or upper abdomen, shortness of breath, dizziness, fatigue, light-headedness, clammy skin, sweating, indigestion, anxiety, feeling faint and possible irregular heartbeat | ✓ | ||
| UNKNOWN | |||
| Allergic reaction: rash, itching, hives, swelling of the face, lips, tongue or throat, difficulty breathing or swallowing | ✓ | ||
| Convulsion: temporary confusion, a staring spell, | ✓ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| stiff muscles, twitch, shiver, uncontrollable jerking movements of the arm(s) and legs, loss of consciousness or awareness | |||
| High blood sugar: frequent urination, thirst, and hunger or rise in blood glucose if measured | ✓ | ||
| Hypotension (low blood pressure): dizziness, fainting, light-headedness, blurred vision, nausea, vomiting, fatigue (may occur when you go from lying or sitting to standing up) | ✓ | ||
| Jaundice (build up of bilirubin in the blood): yellowing of the skin and eyes, dark urine, light coloured stool, itching all over your body | ✓ | ||
| Malignant hyperthermia: sudden fever with stiffness, pain and weakness in your muscles | ✓ | ||
If you/your child have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your/their daily activities, tell your/your child’s healthcare professional.
REPORTING SIDE EFFECTS
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
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Storage:
SUPRANE should only be administered in an adequately equipped facility. SUPRANE must be kept out of reach and sight of children. It is stored at or below 30°C (86°F).
If you want more information about SUPRANE:
- Talk to your healthcare professional.
- Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drugproduct-database.html); the manufacturer’s website (www.baxter.ca), or by calling 1-888-719-9955.
Baxter and Suprane are registered trademarks of Baxter International Inc.