Patient Medication Information: uses, side effects, how to take - Teva-Diltiazem Xc
What is TEVA-DILTIAZEM XC used for?
- the treatment of mild to moderate high blood pressure. TEVA-DILTIAZEM XC is normally used in patients who have tried other treatments for their blood pressure, but did not receive benefits, or had bad side effects.
- the management of effort associated angina (chest pain). TEVA-DILTIAZEM XC can be used with other chest pain medicines when those medicines do not provide enough benefit on their own.
How does TEVA-DILTIAZEM XC work?
TEVA-DILTIAZEM XC belongs to a group of drugs called “calcium channel blockers” or “calcium antagonists”.
- TEVA-DILTIAZEM XC relaxes the arteries, which allows blood to flow freely through them. This helps to lower blood pressure.
- TEVA-DILTIAZEM XC increases the supply of oxygen to the heart muscle. This helps to control chest pain.
What are the ingredients in TEVA-DILTIAZEM XC?
Medicinal ingredients: Diltiazem Hydrochloride
Non-medicinal ingredients: Candelilla wax, colloidal silicon dioxide, corn starch, ethylcellulose, microcrystalline cellulose, eudragit, hypromellose, lactose monohydrate, magnesium stearate, polysorbate, polyethylene oxide, povidone, sugar, talc, titanium dioxide, triacetin
TEVA-DILTIAZEM XC comes in the following dosage forms:
180 mg, 240 mg, 300 mg and 360 mg tablets
Do not use TEVA-DILTIAZEM XC if:
you are pregnant or plan to become pregnant.
- you are a woman of child-bearing potential, unless you and your doctor have decided you should take TEVA-DILTIAZEM XC.
- you are allergic to diltiazem or any of the non-medicinal ingredients in TEVA-DILTIAZEM XC.
- you have very low blood pressure (less than 90 mmHg systolic).
- you have a very slow heartbeat (40 beats/min or less).
- you have any heart rhythm disorders and do not have a pacemaker.
- you have had a heart attack and now have heart failure due to fluid in your lungs.
- you are taking a medicine called dantrolene used for severe muscle spasms or severe fever.
- you are taking a medicine called ivabradine, which is used for heart failure.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take TEVA-DILTIAZEM XC. Talk about any health conditions or problems you
may have, including if you:
- have had a recent heart attack.
- have heart, liver or kidney disease.
- have high blood sugar or diabetes.
- are breastfeeding or planning to breastfeed.
- are 65 years of age or older.
- have a history of heart failure, new shortness of breath, slow heartbeat or low blood pressure. Cases of kidney injury in patients with such conditions have been reported.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with TEVA-DILTIAZEM XC:
- Antifungal medications with a name ending in “azole”;
- Medications used to control the immune system such as cyclosporine;
- Sleeping pills; such as benzodiazepines (midazolam, triazolam);
- Other blood pressure medications: alpha antagonists, beta blockers;
- Heart medications such as amiodarone, digoxin, digitalis, flecainide, nifedipine, propafenone, quinidine, verapamil, ivabradine;
- Anaesthetics;
- Lithium and imipramine used for some types of mental illness;
- Drugs that dilate the blood vessels such as short and long acting nitrates;
- Medications used to control seizures such as carbamazepine, phenobarbital, phenytoin;
- Warfarin used to prevent blood clots;
- Cholesterol lowering medications called “statins” such as simvastatin;
- Theophylline used for breathing problems;
- Terfenadine or ranitidine used for allergies;
- Medications used to control stomach ulcers such as cimetidine;
- Certain antibiotics should not be taken with TEVA-DILTIAZEM XC such as erythromycin, rifampin. Check with your pharmacist if you are not sure;.
- Products that contain calcium such as multivitamins with minerals;
- Drugs to treat inflammation such as corticosteroids, methylprednisolone;
- Dantrolene used for severe muscle spasms or severe fever;
- Acetylsalicylic acid (ASPIRIN®) or drugs used to thin blood;
- X-ray contrast agents.
Alcohol
Drinking alcohol while taking TEVA-DILTIAZEM XC may cause low blood pressure when you go from lying or sitting to standing up. This is more likely to occur after the first dose or when the dose is increased. Tell your doctor if you experience dizziness, light-headedness, fainting decreased blood pressure or increased heart rate.
Grapefruit juice
Drinking grapefruit juice while taking TEVA-DILTIAZEM XC may cause headache, irregular heartbeat, edema (swelling), unexplained weight gain and chest pain. Tell your doctor if this happens to you. Your doctor may recommend that you avoid grapefruit juice while taking TEVA-DILTIAZEM XC.
How to take TEVA-DILTIAZEM XC:
- Take TEVA-DILTIAZEM XC once daily at bedtime.
- TEVA-DILTIAZEM XC can be taken with or without food.
- It is important to take TEVA-DILTIAZEM XC at night, at approximately the same time.
- DO NOT chew or crush TEVA-DILTIAZEM XC tablets.
Usual dose:
High Blood Pressure: the usual starting dose is 180 mg to 240 mg once a day. Maximum daily dose: 360 mg once a day.
Chest Pain (angina): your doctor will decide the best dose for you. The usual starting dose is 180 mg once a day. Your dose may be slowly increased (over 7 to 14 days). Maximum daily dose: 360 mg once a day.
Overdose:
| If you think you, or a person you are caring for, have taken too much TEVA-DILTIAZEM XC, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms. |
Missed Dose:
If you miss a dose, take it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and take your next dose as scheduled. Do not take two doses at the same time.
What are possible side effects from using TEVA-DILTIAZEM XC?
These are not all the possible side effects you may feel when taking TEVA-DILTIAZEM XC. If you experience any side effects not listed here, tell your healthcare professional.
- headache, dizziness, malaise;
- nausea (feeling like vomiting);
- flushing (facial redness) or feeling unusually warm;
- rash;
- temporary swelling;
- unusual tiredness and weakness;
- upset stomach or indigestion.
TEVA-DILTIAZEM XC can cause abnormal blood test results. Your healthcare professional will decide when to perform blood tests and will interpret the results.
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |||
|---|---|---|---|---|---|
| Only if severe | In all cases | ||||
| Common | |||||
| Allergic reaction: rash, hives, swelling of the face, lips, tongue or throat, difficulty swallowing or breathing | √ | ||||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help |
|---|
| Only if severe | In all cases | ||
|---|---|---|---|
| Fast, slow or irregular heartbeat | √ | ||
| Hypotension (low blood pressure): dizziness, fainting, light-headedness, blurred vision, nausea, vomiting, fatigue (may occur when you go from lying or sitting to standing up). | √ | ||
| Peripheral edema: (swelling of the legs or hands): swollen or puffy legs, ankles or hands, feeling heavy, achy or stiff | √ | ||
| Respiratory tract infection: (a cold): runny or stuffy nose, sore throat, cough, sinus congestion, body aches, headache, sneezing, fever, generally feeling unwell | √ | ||
| Uncommon | |||
| Angina (chest pain): discomfort in the shoulder, arm, back, throat, jaw or teeth; pain or pressure in the chest | √ | ||
| Depression: (sad mood that won’t go away): difficulty sleeping or sleeping too much, changes in appetite or weight, feelings of worthlessness, guilt, regret, helplessness or hopelessness, withdrawal from social situations, family, gatherings and activities with friends, reduced libido (sex drive) and thoughts of death or suicide. If you have a history of depression, your depression may become worse | √ | ||
| Eye problems: blurred vision, loss of vision in the eye, increased sensitivity of the eyes to light, eye pain or redness, swelling and itching of the eyelids | √ | ||
| Heart block (a disease in the electrical system of the heart): light-headedness, fainting, irregular heartbeat | √ | ||
| Heart failure: shortness of breath, fatigue and weakness, leg swelling in legs, ankles and feet, cough, lack of appetite, nausea, rapid or irregular heartbeat, reduced ability to exercise | √ | ||
| Hyperglycemia: (high blood sugar): increased thirst and hunger, frequent urination, thirst, and hunger headache, blurred vision, fatigue | √ | ||
| Rare | |||
| Kidney problems: nausea, vomiting, fever, swelling of extremities, fatigue, thirst, dry skin, irritability, dark urine, increased or decreased urine output, blood in the urine, rash, weight gain (from retaining fluid), loss of appetite, | √ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help |
|---|
| Only if severe | In all cases | ||
|---|---|---|---|
| abnormal blood test results, mental status changes (drowsiness, confusion, coma) | |||
| Liver problems: yellowing of the skin or eyes, dark urine, stomach pain or swelling, nausea, vomiting, unusual tiredness | √ | ||
| Severe skin reactions: fever, severe rash, swollen lymph glands, flu-like feeling, blisters and peeling skin that may start in and around the mouth, nose, eyes and genitals and spread to other areas of the body, yellow skin or eyes, shortness of breath, dry cough, chest pain or discomfort, feeling thirsty, urinating less often, less urine | √ | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
- Store tablets at room temperature (15-30°C).
Keep out of reach and sight of children.
If you want more information about TEVA-DILTIAZEM XC:
- Talk to your healthcare professional
- Find the full Product Monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://health-products.canada.ca/dpd-bdpp/index-eng.jsp); the manufacturer’s website http://www.tevacanada.com; or by calling 1-800-268-4127 ext. 3; or email druginfo@tevacanada.com.