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Tigecycline for Injection: Uses, Side Effects and Dosage

Status:
Prescription (Rx) Facts
Strength:
50 mg
Active ingredient:
ATC code:
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Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - Tigecycline for Injection

What is TIGECYCLINE FOR INJECTION used for?

TIGECYCLINE FOR INJECTION is an antibiotic medicine. It is used to treat the following serious bacterial infections in adults:

  • skin infections
  • abdomen infections
  • community acquired pneumonia (lung infections caught outside of hospitals or other health care facilities)

Antibacterial drugs like TIGECYCLINE FOR INJECTION treat only bacterial infections. They do not treat viral infections. Although you may feel better early in treatment, TIGECYCLINE FOR INJECTION should be used exactly as directed. Misuse or overuse of TIGECYCLINE FOR INJECTION could lead to the growth of bacteria that will not be killed by TIGECYCLINE FOR INJECTION (resistance). This means that TIGECYCLINE FOR INJECTION may not work for you in the future.

How does TIGECYCLINE FOR INJECTION work?

TIGECYCLINE FOR INJECTION belongs to the class of medicines called tetracycline antibiotics. It works by helping to stop the growth of bacteria responsible for your infection.

What are the ingredients in TIGECYCLINE FOR INJECTION?

Medicinal ingredient: Tigecycline

Non-medicinal ingredients: L-arginine, hydrochloric acid, sodium hydroxide.

TIGECYCLINE FOR INJECTION comes in the following dosage forms:

TIGECYCLINE FOR INJECTION comes as a powder to be mixed with a specific liquid and injected slowly into a vein.

TIGECYCLINE FOR INJECTION is supplied as a 5 mL single-dose glass vial.

Each TIGECYCLINE FOR INJECTION vial contains 50 mg of tigecycline powder.

Do not use TIGECYCLINE FOR INJECTION if:

  • you are allergic to tigecycline,
  • you are allergic to any other ingredients of TIGECYCLINE FOR INJECTION (see What are the ingredients in TIGECYCLINE FOR INJECTION?),
  • you are allergic to other tetracycline antibiotics such as doxycycline, minocycline, and tetracycline.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take TIGECYCLINE FOR INJECTION. Talk about any health conditions or problems you may have, including if you:

  • have other infections.
  • have liver problems.

  • are pregnant or planning to become pregnant. TIGECYCLINE FOR INJECTION may cause fetal harm.

  • are breastfeeding or planning to breastfeed. It is not known if tigecycline passes into breast milk. There is a possibility of permanent staining of the teeth of the child.

Children

TIGECYCLINE FOR INJECTION is for use in adults aged 18 and over. There is no experience with the use of tigecycline in children under 18 years of age. TIGECYCLINE FOR INJECTION may cause enamel loss and staining in developing teeth.

Other warnings you should know about:

While taking TIGECYCLINE FOR INJECTION

  • If you develop a racing heartbeat (palpitations) or faint, contact your doctor immediately.

  • Do not drive or operate machinery. TIGECYCLINE FOR INJECTION may cause side effects such as dizziness.

  • Follow your healthcare professional’s instructions carefully.
  • If your condition does not improve in a few days or if it gets worse, contact your healthcare professional.

  • TIGECYCLINE FOR INJECTION may make your skin more sensitive to sunlight than it is normally. To protect your skin from sunburn, you should:

    • Wear protective clothing and sunglasses
    • Limit your time in the sun especially between 11 a.m. and 4 p.m.
    • Use sunscreen
    • Avoid using tanning beds

  • TIGECYCLINE FOR INJECTION may cause a condition in which the pressure inside the skull is increased (Pseudotumor cerebri). If you experience any of these symptoms, call your healthcare professional immediately:

    • Severe headache
    • Buzzing sound in the ears (tinnitus)
    • Severe dizziness
    • Vision changes
    • Severe nausea
  • If you develop severe diarrhea during your treatment with TIGECYCLINE FOR INJECTION or over 2 months after your treatment is finished, call your healthcare professional immediately (see What are possible side effects from using TIGECYCLINE FOR INJECTION? Section below).
  • Do not use any medicine to treat your diarrhea without first checking with your doctor.
  • Your healthcare professional may order some blood tests for you before and while you are on treatment with TIGECYCLINE FOR INJECTION.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with TIGECYCLINE FOR INJECTION:

  • anticoagulants (blood thinners) such as warfarin
  • contraceptive pill (birth control pill). Talk to your doctor about the need for an additional method of contraception while receiving TIGECYCLINE FOR INJECTION.
  • drugs that weaken the immune system such as tacrolimus or cyclosporine. Taking TIGECYCLINE FOR INJECTION may lead to increased levels of these drugs in your body. Tell your healthcare professional if you are taking tacrolimus or cyclosporine so that blood levels can be checked before, during and after taking TIGECYCLINE FOR INJECTION. The dose of tacrolimus or cyclosporine may be adjusted while you are taking TIGECYCLINE FOR INJECTION.

How to take TIGECYCLINE FOR INJECTION:

  • Your healthcare professional will give TIGECYCLINE FOR INJECTION by intravenous infusion (slow drip through a needle into a large vein) over a period of 30 to 60 minutes.

Usual dose:

The usual adult dose of TIGECYCLINE FOR INJECTION is 100 mg for the first dose, followed by 50 mg every 12 hours.

The length of your treatment depends on the type of infection you have and how your body responds to TIGECYCLINE FOR INJECTION.

Overdose:

Missed Dose:

If you are concerned that you may have missed a dose, talk to your doctor or nurse immediately.

What are possible side effects from using TIGECYCLINE FOR INJECTION?

These are not all the possible side effects you may have when taking TIGECYCLINE FOR INJECTION. If you experience any side effects not listed here, tell your healthcare professional.

Side effects may include:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Dizziness
  • Skin rash
  • Itching
  • Headache
  • Abdominal discomfort

If you experience symptoms such as severe diarrhea (bloody or watery) with or without fever, abdominal pain, or tenderness, you may have Clostridium difficile colitis (bowel inflammation). If this occurs, stop taking TIGECYCLINE FOR INJECTION and contact your healthcare professional immediately.

If you think you, or a person you are caring for, have taken too much TIGECYCLINE FOR INJECTION, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms.

Serious side effects and what to do about them

Symptom / effectTalk to your healthcare professionalStop taking drug and get immediate medical help
Only if severeIn all cases
UNCOMMON

Injection site reaction (pain,

redness, inflammation)

√

Vein irritations from the injection

(including pain, inflammation, swelling and clotting)

√
Fever√
Chills√
Chest pain√

Decreased platelets (cells in the blood that help the blood clot)

  • Unusual bruising or bleeding
  • Pinpoint red spots on the skin
√
Jaundice (dark urine, yellowness of skin or eye)√

Inflammation of the pancreas

(severe upper stomach pain, often with nausea and vomiting)

√
Serious Skin Reactions (Stevens Johnson syndrome): flu-like symptoms (fever, headache, cough, body aches, etc.) followed by skin blisters or peeling√
Allergic reactions (e.g. rash, difficulty breathing, tightening of chest, swelling of lips, tongue or throat, etc.)√

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Storage:

The healthcare professional will store the product under appropriate conditions. Keep out of reach and sight of children.

If you want more information about TIGECYCLINE FOR INJECTION:

  • Talk to your healthcare professional
  • Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug- product-database.html; the manufacturer’s website www.pharmaris.com, or by calling 1-866-913- 7955.

Last Authorized: MAY 4, 2022

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health- canada/services/drugs-health-products/medeffect-canada.html) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02484749

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The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Tigecycline for Injection

Rx or OTC
Prescription (Rx)?
DIN 02484749
Schedule(s) PRESCRIPTION
Active ingredient(s) Tigecycline 50 MG
Dosage form(s) Powder For Solution
Route(s) of administration Intravenous
Drug class (WHO ATC)
  1. J Antiinfectives for systemic use
    1. J01 Antibacterials for systemic use
      1. J01A Tetracycline antibiotics
        1. J01AA Tetracyclines
          1. J01AA12 Tigecycline
Company PHARMARIS CANADA INC
Current status Approved
Current status date May 6, 2022

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.