Tobramycin for Injection: Uses, Side Effects and Dosage

What are Tobramycin Injection, USP and Tobramycin for Injection, USP used for?

Tobramycin Injection, USP and Tobramycin for Injection, USP are used to treat certain bacterial infections:

• of the chest and lungs (lower respiratory tract)..
• in the blood.
• of the kidneys and urinary bladder (urinary tract).
• in the brain, spinal cord and nerves (central nervous system).
• of the skin and muscle.

Antibacterial drugs like Tobramycin Injection, USP and Tobramycin for Injection, USP treat only bacterial infections. They do not treat viral infections such as the common cold. Although you may feel better early in treatment, Tobramycin Injection, USP and Tobramycin for Injection, USP should be used exactly as directed. Misuse or overuse of Tobramycin Injection, USP and Tobramycin for Injection, USP could lead to the growth of bacteria that will not be killed by Tobramycin Injection, USP and Tobramycin for Injection, USP (resistance). This means that Tobramycin Injection, USP and Tobramycin for Injection, USP may not work for you in the future.

How does Tobramycin Injection, USP and Tobramycin for injection, USP work?

Tobramycin is an antibiotic. It works by killing or slowing the growth of certain types of bacteria that cause the infection

What are the ingredients in Tobramycin Injection, USP and Tobramycin for Injection, USP?

Tobramycin Injection:

Medical ingredients: Tobramycin

Non-medical ingredients: edetate disodium, phenol, sodium metabisulfite in water for injection. May also contain sodium hydroxide and/or sulfuric acid for pH adjustment.

Tobramycin for Injection:

Medical ingredients: Tobramycin supplied as Tobramycin sulfate

Non-medical ingredients: None

Tobramycin Injection, USP and Tobramycin for Injection, USP come in the following dosage forms:

Tobramycin Injection, USP:

• Liquid for Injection - 10 mg / mL and 40 mg / mL

Tobramycin for Injection, USP:

• Powder for Injection – 1.2g / vial

Do not use Tobramycin Injection, USP and Tobramycin for Injection, USP if:

• you are allergic to tobramycin or any ingredients in the drug (See what are the ingredients in Tobramycin

  Injection, USP and Tobramycin for Injection, USP).

• you are allergic to other aminoglycosides.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Tobramycin Injection, USP or Tobramycin for Injection, USP. Talk about any health conditions or problems you may have, including if you:

• have drug allergies.
• have hearing or balance problems.
• have kidney problems.
• have Myasthenia gravis (a muscle condition).
• have Parkinson’s Disease.

• are pregnant or planning to become pregnant.

• are breastfeeding or planning to breastfeed

Other warnings you should know about:

Tobramycin Injection, USP, Tobramycin for Injection, USP and other similar aminoglycosides have been known to cause hearing and balance problems and kidney problems. Your doctor will observe you carefully for warning signs of these events after giving you Tobramycin Injection, USP or Tobramycin for Injection, USP.

Your doctor may monitor the level of Tobramycin Injection, USP and Tobramycin for Injection, USP in your blood through blood tests, especially if you are taking, or have taken in the recent past, certain medications that can interact with tobramycin.

Tell your healthcare professional about all the medicines you take, or have taken in the recent past, including any drugs (prescription and bon-prescription), vitamins, minerals, natural supplements or alternative medicines.

The following may interact with Tobramycin Injection, USP and Tobramycin for Injection, USP:

• aminoglycosides (e.g. amikacin, streptomycin, neomycin, kanamycin, gentamicin, and paromomycin)
• amphotericin B
• cephaloridine
• cisplatin
• colistin
• decamethonium
• diuretics (specifically potent diuretics)
• polymyxin B
• succinylcholine
• tubocurarine
• vancomycin
• viomycin

How to take Tobramycin Injection, USP and Tobramycin for Injection, USP:

Tobramycin Injection, USP and Tobramycin for Injection, USP are for intramuscular injection or intravenous infusion after dilution. The usual intravenous infusion time is 20 to 60 minutes.

Tobramycin Injection, USP and Tobramycin for Injection, USP will be given to you by a doctor or nurse in a hospital or clinical setting.

Usual dose:

.

Your doctor will give you the most appropriate dose based on your age, weight, the type of infection you have, and any medical conditions you may have.

You may receive Tobramycin Injection, USP or Tobramycin for Injection, USP several times a day over a period of 7 to 10 days. Your doctor may decide to give it to you for a longer period depending on the type and severity of your bacterial infection.

Overdose:

If you think you have taken too much Tobramycin Injection, USP or Tobramycin for Injection, USP, contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms.

Missed Dose:

If you have missed a dose of medication, contact your healthcare professional.

What are possible side effects from using Tobramycin Injection, USP and Tobramycin for Injection, USP?

These are not all the possible side effects you may feel when taking Tobramycin. If you experience any side effects not listed here, contact your healthcare professional.

Stop taking Tobramycin Injection, USP and Tobramycin for Injection, USP and contact your doctor if:

1. a)

   you have symptoms of an allergic reaction such as:

   • rash, hives, itching or skin irritation.
   • reaction at the injection site.
2. b)

   you have severe diarrhea (bloody or watery) with or without:

   • fever
   • stomach pain or tenderness

You may have Clostridium difficile colitis (bowel inflammation). See your doctor right away.

Other side effects include:

• diarrhea
• fever
• headache
• nausea
• tiredness
• vomiting

If you have troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-

  canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or

• Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage

Store in the original container between 15°C and 30°C.

Keep out of reach and sight of children.

If you want more information about Tobramycin Injection, USP and Tobramycin for Injection, USP:

• Talk to your healthcare professional

• Find the full product monograph that is prepared for healthcare professionals and includes this Patient

  Medication Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada.html); Fresenius Kabi Canada’s website (https://www.fresenius-kabi.com/en-ca/), or by calling 1-877-821-7724.

Serious side effects and what to do about them

Fresenius Kabi Canada Ltd. 165 Galaxy Blvd, Suite 100 Toronto, ON M9W 0C8

Last revised: October 23, 2018