Zepbound: Uses, Side Effects and Dosage

Serious warnings and precautions box

What ZEPBOUND is used for:

ZEPBOUND is used together with a low calorie diet and exercise :

• to help lose weight and keep the weight off over a long term. It is used in adults who have a body mass index (BMI) that is:

  • 30 kg/m² or higher (obesity), or

  • between 27 kg/m² and 30 kg/m² (overweight). These patients will also have at least one other health problem related to weight such as:

    • high blood pressure,
    • high levels of fats in the blood,
    • pre-diabetes,
    • diabetes,
    • obstructive sleep apnea, or
    • heart disease
• to treat obstructive sleep apnea (OSA) in adults with moderate to severe OSA and obesity.

How ZEPBOUND works:

Tirzepatide, the medicinal ingredient in ZEPBOUND acts on two different receptors (GIP and GLP-1) in the body to increase feelings of fullness, and decrease feelings of hunger. This leads to less appetite and lower intake of calories. ZEPBOUND also reduces food cravings for high sugar and high fat foods and reduces the brain response that is related to these types of foods.

• Tirzepatide, the medicinal ingredient in ZEPBOUND, increased the risk of developing thyroid C-cell tumors in rats. It is not known if the risk seen in rats applies to humans. It is uncertain if ZEPBOUND may increase your risk for developing thyroid C-cell tumors, including medullary thyroid carcinoma.

• Do not use ZEPBOUND if you:

  • have a personal or family history of Medullary Thyroid Cancer (MTC);
  • have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• Your healthcare professional will speak to you about the risk and symptoms of thyroid tumors.

The ingredients in ZEPBOUND are:

Medicinal ingredient: tirzepatide

Non-medicinal ingredients: benzyl alcohol (preservative), glycerin, hydrochloric acid solution, phenol (preservative), sodium chloride, sodium hydroxide solution, sodium phosphate dibasic heptahydrate, and water for injection.

ZEPBOUND comes in the following dosage form:

Solution in a multi-dose prefilled pen (KwikPen) containing 4 doses: 2.5 mg/0.6 mL, 5 mg/0.6 mL, 7.5 mg/0.6 mL, 10 mg/0.6 mL, 12.5 mg/0.6 mL, and 15 mg/0.6 mL

Do not use ZEPBOUND if:

• you are allergic to tirzepatide or to any ingredient in ZEPBOUND or component of its container. This includes benzyl alcohol, which is used as a preservative.
• you or a member of your family has ever had Medullary Thyroid Cancer (MTC).
• you have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
• you are pregnant.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you use ZEPBOUND. Talk about any health conditions or problems you may have, including if you:

• have a heart condition that causes an increase in heart rate
• experienced severe allergic reactions and swelling when taking GLP-1 receptor agonist medicines like liraglutide or semaglutide
• have severe problems with your stomach (gastroparesis) or food digestion
• have liver problems
• have serious kidney problems
• use insulin or medicines that stimulate the pancreas to make insulin
• have previously attempted to take your own life or have had thoughts of suicide

Other warnings you should know about:

Gastrointestinal (stomach and intestine) problems

• ZEPBOUND slows stomach emptying so food passes more slowly through your stomach.
• Gastrointestinal problems including nausea, vomiting and diarrhea have been reported in people who use ZEPBOUND. These symptoms are sometimes severe. Tell your healthcare professional if you have stomach problems that are severe or will not go away.

Gallbladder Disease

• You may suddenly develop symptoms of gallbladder disease while using ZEPBOUND.
• Gallbladder disease can include inflammation of the gallbladder (cholecystitis), or gallstones blocking the bile duct (biliary colic).
• Symptoms may include sudden and intensifying pain in your abdomen, your right shoulder, or between your shoulder blades. Seek immediate medical attention if you experience severe abdominal pain, yellowing of your skin, or high fever with chills. If you think you might have a problem with your gallbladder, consult your healthcare professional.

Benzyl alcohol

• Benzyl alcohol is a preservative used in ZEPBOUND multi-dose prefilled pen (KwikPen). Benzyl alcohol can cause you to develop metabolic acidosis (acid in the blood). Metabolic acidosis can develop when large amounts of benzyl alcohol build-up in your body. Talk to your healthcare professional if you:

  • are taking other medications containing benzyl alcohol.
  • have liver or kidney problems.

Children and Adolescents

ZEPBOUND is not recommended in children and adolescents under 18 years.

Pregnancy

• If you are pregnant, able to get pregnant or think you are pregnant, there are specific risks you should discuss with your healthcare professional.
• Using ZEPBOUND while you are pregnant may harm your unborn baby.
• Avoid becoming pregnant while you are using ZEPBOUND.
• Use effective birth control during treatment.

• If you are already using a birth control that is taken by mouth:

  • Switch to a different type of birth control medicine, or
  • Add a barrier method of birth control (e.g., condoms). Use this method for 4 weeks when beginning treatment with ZEPBOUND and for 4 weeks after each time your dose is increased.
• If you wish to become pregnant, you should stop using ZEPBOUND at least 1 month before trying to get pregnant.

Breastfeeding

• ZEPBOUND may pass into your breast milk. Talk to your healthcare professional about the potential risks of breastfeeding your baby while taking ZEPBOUND.

Driving and Using Machines

• Low blood sugar (hypoglycemia) may affect your ability to concentrate. Avoid driving or using machines if you have any signs of low blood sugar.

Pancreas Problems

• Using ZEPBOUND can cause an inflamed pancreas (acute pancreatitis).
• Tell your healthcare professional if you have or have had pancreas problems such as inflammation of the pancreas.
• Your healthcare professional will monitor you for symptoms of acute pancreatitis. Speak to your healthcare professional immediately if you have severe pain in the stomach area or back which does not go away.

Serious Allergic Reactions

• Stop using ZEPBOUND and get medical help right away if you have any symptoms of a serious allergic reaction. This can include itching, rash, or difficulty breathing. See “What are possible side effects from using ZEPBOUND” for more symptoms of an allergic reaction.

Blood Tests

• Your blood sugar levels should be monitored at the start of treatment if you are taking ZEPBOUND with anti-diabetic medicines known as sulfonylurea or insulin. Monitoring your blood sugar levels will help reduce the risk of developing hypoglycemia (low blood sugar).
• Your healthcare professional will monitor your blood sugar levels periodically during your treatment with ZEPBOUND.

Kidney Problems

• During treatment with ZEPBOUND, you may experience feeling sick (nausea) or being sick (vomiting), and diarrhea. These side effects can cause dehydration (loss of fluids). Dehydration can lead to problems with your kidneys, such as sudden kidney failure.
• It is therefore important to drink plenty of fluids to prevent dehydration.
• Talk to your healthcare professional if you have any questions or concerns.

Eye problems

• Diabetic Eye Disease (Retinopathy) in Patients with Type 2 Diabetes Mellitus:

  • Quick improvements in blood sugar control may cause a temporary worsening of diabetic eye disease. You may need medical treatment. It could also lead to a loss of vision.
  • Tell your healthcare professional if you have diabetic eye disease (retinopathy) or if you experience vision problems during treatment with ZEPBOUND.

• Non-arteritic anterior ischaemic optic neuropathy (NAION):

  • If you experience a sudden loss of vision or rapidly worsening eyesight during treatment with ZEPBOUND, urgently contact your healthcare professional. This may be caused by NAION. Your healthcare professional will refer you for an eye examination by an ophthalmologist and you may have to stop your treatment with ZEPBOUND.

Malnutrition

• Nutrition problems, sometimes severe, have been reported in people who use ZEPBOUND. This can cause you to lose too much weight and have low vitamin, mineral and/or protein levels.
• While you are using ZEPBOUND, your healthcare professional may give you guidance on nutrition and/or recommend you take vitamins or supplements.

Food or Liquid Getting into Lungs During Anesthesia

• Some patients using medicines like ZEPBOUND have had problems with food or liquid from their stomach getting into their lungs while under general anesthesia or deep sedation. Tell your healthcare professional that you are using ZEPBOUND before you have a procedure that requires general anesthesia or deep sedation.

Depression or Thoughts of Suicide

• Pay attention to changes in your mood, behaviours, feelings, or thoughts. Call your healthcare professional right away if you have any:

  • thoughts or behaviours of harming or killing yourself
  • changes to your mental health that are new, worse, or worry you.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with ZEPBOUND:

• birth control medicines that are taken by mouth. If you take these medicines while you are using ZEPBOUND, the birth control may not work as well.
• diabetes medicines known as a sulfonylurea (e.g., glyburide, gliclazide, glimepiride) or insulin. Combining these medicines with ZEPBOUND might increase the risk of getting low blood sugar. Your healthcare professional may tell you to lower your regular dose of these drugs when adding ZEPBOUND treatment.
• medicines that may increase your heart rate.
• other incretin medicines. The use of ZEPBOUND in combination with other GLP-1 receptor agonists or with DPP-4 inhibitors has not been studied and ZEPBOUND should not be used in combination with those drugs.

How to inject ZEPBOUND:

• ZEPBOUND is an injection that is given subcutaneously. Do not inject it into a vein or muscle.
• Inject ZEPBOUND once per week at any time of the day, with or without food; however, always inject on the same day each week. Set a reminder on a calendar to remind yourself of your weekly injection.
• Each month you will use: 1 multi-dose prefilled pen (KwikPen). Each KwikPen contains enough medication for 4 doses.
• Read the Instructions for Use and watch the instructional video before injecting ZEPBOUND. These provide directions on how to inject ZEPBOUND correctly.
• Before using ZEPBOUND, your healthcare professional will train you on how to properly inject the medication. Do not use ZEPBOUND without having received this training. If you do not understand the instructions or have any questions, talk with your healthcare professional.
• Use ZEPBOUND exactly as your healthcare professional has told you. Do not change your dose or stop using ZEPBOUND without talking to your healthcare professional.
• While you are using ZEPBOUND, you should eat about 500 calories less than you normally do. You should also do at least 150 minutes of moderate exercise each week.
• The KwikPen has glass parts. Handle it carefully. If you drop the KwikPen on a hard surface, do not use the medicine. Use a new KwikPen for your injection.
• The best places to give yourself the injection are your stomach area (abdomen) or upper leg (thigh). Another person should give you the injection in the back of your upper arm.

• Do not use the same site for each injection. Change (rotate) your injection site with each injection to avoid skin problems like thinning, thickening, or lumps. Do not inject:

  • where the skin has pits, is thickened or has lumps
  • where the skin is tender, bruised, scaly or hard
  • into scars or damaged skin
  • into the same injection site used for other medicines.

You may use the same area of the body but be sure to choose a different site in that area.

• Changing the day of the week for your injection:

  • If necessary, you can change the day of the week that you inject ZEPBOUND. If you need to do this, wait at least 3 days after your last injection.

Usual Adult Dose:

• Your healthcare professional will decide the dose that is right for you. You may receive a different dose depending on:

  • whether you are taking medications for diabetes
  • your physical health (e.g., weight, other illnesses, physical activity)
  • your diet

Usual Adult Dose for Chronic Weight Management:

• The recommended starting dose is 2.5 mg injected subcutaneously once per week for 4 weeks.
• After 4 weeks, your dose will go up to 5 mg injected subcutaneously once per week.
• If your dose is increased, it will go up by 2.5 mg at a time after using your current dose for at least 4 weeks until you reach your maintenance dose.
• The recommended maintenance dosage for Chronic Weight Management in adults is 5 mg, 10 mg, or 15 mg injected subcutaneously once per week.
• The maximum recommended dose is 15 mg once per week injected subcutaneously.

Usual Adult Dose for Obstructive Sleep Apnea:

• The recommended starting dose is 2.5 mg injected subcutaneously once per week for 4 weeks.
• After 4 weeks, your dose will go up to 5 mg injected subcutaneously once per week.
• If your dose is increased, it will go up by 2.5 mg at a time after using your current dose for at least 4 weeks until you reach your maintenance dose.
• The recommended maintenance dosage for Obstructive Sleep Apnea in adults is 10 mg, or 15 mg injected subcutaneously once per week.
• The maximum recommended dose is 15 mg once per week injected subcutaneously.

If you have moderate to severe obstructive sleep apnea (OSA): Some people with moderate to severe OSA need to use a positive airway pressure (PAP) machine to help them breathe during sleep. ZEPBOUND is not a replacement for a PAP machine if you need one. If you use a PAP machine, do not stop, or change how you use it on your own. Your healthcare professional will decide whether you should start, continue, or change your PAP therapy while you are using ZEPBOUND.

Overdose:

If you use too much tirzepatide (the medicinal ingredient in ZEPBOUND) you may have gastrointestinal side effects including nausea.

If you think you, or a person you are caring for, have injected too much ZEPBOUND, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844-POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

Missed Dose:

If you miss a dose and it has been:

• 4 days (96 hours) or less since you should have used ZEPBOUND, use it as soon as you remember. Then inject your next dose on your usual day.
• more than 4 days (96 hours) since you should have used ZEPBOUND, skip the missed dose. Then inject your next dose on your usual day.

Possible side effects from using ZEPBOUND:

These are not all the possible side effects you may have when using ZEPBOUND. If you experience any side effects not listed here, tell your healthcare professional.

• Belching
• Bloating of the stomach
• Change in taste
• Constipation
• Decreased appetite
• Diarrhea
• Dizziness
• Dry mouth
• Feeling tired
• Gas (flatulence)
• Hair loss
• Indigestion
• Increased heart rate
• Injection site reactions (bruising, pain, irritation, itching, and rash)
• Low blood pressure
• Nausea
• Reflux or heart burn – also called gastro-esophageal reflux
• Stomach pain
• Unusual skin sensations - such as burning, tingling or pricking
• Vomiting

ZEPBOUND can cause abnormal blood test results. Your healthcare professional will do blood tests during your treatment and will interpret the results.

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (www.canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

Store ZEPBOUND in a refrigerator at 2°C to 8°C up to the expiration date. Do not use ZEPBOUND beyond the expiration date.

If needed, each multi-dose prefilled pen can be stored unrefrigerated at temperatures below 30°C for up to 30 days.

Do not freeze ZEPBOUND. Do not use ZEPBOUND if frozen.

Protect ZEPBOUND from light.

Each ZEPBOUND multi-dose prefilled pen (KwikPen) contains 4 doses. Discard your KwikPen after using it once per week for 4 weeks (4 doses). Put all used KwikPens into a puncture-resistant (sharps) container, or discard them in accordance with local requirements, once all the doses have been used. There may be some medicine still left in the KwikPen after the 4 weekly doses were given.

Keep out of reach and sight of children.

If you want more information about ZEPBOUND:

• Talk to your healthcare professional.
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada Drug Product Database website: (https://health-products.canada.ca/dpd-bdpp/); the manufacturer’s website www.lilly.ca, or by calling 1-888-545-5972.

ZEPBOUND^® and KwikPen^® are registered trademarks of Eli Lilly and Company.

Date of Authorization: 2026-06-11

B4.0-NL-ZEP-0004-CA-PMI-20260604

INSTRUCTIONS FOR USE

^PrZEPBOUND^®

tirzepatide injection

multi-dose prefilled pen (KwikPen^®) for subcutaneous use

Each pen contains 4 fixed doses, one dose taken weekly.

2.5 mg/0.6 mL multi-dose prefilled pen

5 mg/0.6 mL multi-dose prefilled pen

7.5 mg/0.6 mL multi-dose prefilled pen

10 mg/0.6 mL multi-dose prefilled pen

12.5 mg/0.6 mL multi-dose prefilled pen

15 mg/0.6 mL multi-dose prefilled pen

Important information you need to know before injecting ZEPBOUND

Talk to your healthcare provider about how to inject ZEPBOUND the right way. This INSTRUCTIONS FOR USE is written for the person who will be using ZEPBOUND. This may be you or a person you are caring for. After training from a healthcare professional, ZEPBOUND may be self injected or given by a caregiver.

Read this “INSTRUCTIONS FOR USE” and the Patient Medication Information each time you use your ZEPBOUND multi-dose prefilled pen (KwikPen) and each time you get a new KwikPen. There may be new information. This information does not take the place of talking to your healthcare professional about your medical condition or your treatment.

• ZEPBOUND comes in a multi-dose single-patient-use prefilled pen (KwikPen).
• One KwikPen contains 4 doses of 0.6 mL each. One dose is taken each week.
• Inject one dose each week under the skin (subcutaneously) only.
• After you have taken the 4th dose (a month’s treatment), you will see leftover medicine in the KwikPen. This is normal. The leftover medicine ensures that the KwikPen works correctly. Even though the KwikPen still has medicine in it, do not use it. Throw it away in a sharps disposal container. The KwikPen will prevent you from dialing a full dose after you have given yourself the 4th dose. You will not be able to turn the knob after you have given yourself the 4th dose.
• Do not transfer the medicine from your KwikPen into a syringe.
• Do not inject the leftover medication.
• Do not share your KwikPen with other people, even if the pen needle has been changed. You may give other people a serious infection or get a serious infection from them.
• People who are blind or have vision problems should not use the KwikPen without help from a person trained to use the KwikPen.

Guide to parts

Parts of the ZEPBOUND multi-dose prefilled pen (KwikPen)

Supplies needed to give your injection

• 1 ZEPBOUND multi-dose prefilled pen (KwikPen)

• 1 pen needle (as recommended by your healthcare professional)

  • Alcohol swab
  • Gauze or cotton ball
  • Sharps disposal container or household container

Preparing to inject ZEPBOUND

Step 1:

• Wash your hands with soap and water.

Step 2:

• Pull the KwikPen cap straight off.

• Inspect the KwikPen and label. Do not use if:

  • the medication name or dose strength does not match your prescription.
  • the KwikPen is expired (EXP) or looks damaged.
  • the medication has been frozen, has particles, is cloudy, or is discolored. Make sure the medicine in the KwikPen is colourless to slightly yellow.

Step 3:

• Wipe the red inner seal with an alcohol swab.

Step 4:

• Select a new pen needle. Always use a new pen needle for each injection to help prevent infections and blocked needles.
• Pull off the paper tab from the outer needle shield.

Step 5:

• Push the capped pen needle straight onto the KwikPen and twist the pen needle on until it is tight.

Step 6:

a. Pull off the outer needle shield and keep it. This will be reused.

b. Pull off the inner needle shield. Put it in your household trash.

a. Outer needle shield

b. Inner needle shield

Step 7:

• Slowly turn the dose knob until you hear 2 clicks and the extended line shown in the dose window aligns with the dose indicator.

This is the prime position. It can be corrected by turning the dose knob in either direction until the prime position is achieved.

Step 8:

• Hold your KwikPen with the needle pointing up.
• Tap the cartridge holder gently to collect air bubbles at the top.

Step 9:

• Release some medicine into the air by pushing the dose knob in until it stops, then slowly count to 5 while holding the dose knob. The icon must be shown in the dose window. Do not inject into your body.

  Priming removes air from the cartridge and makes sure that your KwikPen is working correctly. Your KwikPen has been primed if a small amount of medicine comes out of the tip of the pen needle.

  • If you do not see medicine at the tip of the needle, repeat steps 7-9, no more than 2 additional times.
  • If you still do not see medicine, then change the pen needle and repeat steps 7-9, no more than 1 additional time.

• If you still do not see medicine, contact Lilly at 1-888-545-5972.

Injecting ZEPBOUND

Step 10:

• Choose an injection site.

  a. You or another person can inject the medicine in your thigh or stomach (abdomen) at least 5 centimeters from the belly button (see the image).

  b. Another person should give you the injection in the back of your upper arm.

• Change (rotate) your injection site each week. You may use the same area of your body but be sure to choose a different injection site in that area.

Do not inject:

• where the skin has pits, is thickened or has lumps
• where the skin is tender, bruised, scaly or hard
• into scars or damaged skin
• into the same injection site used for other medicines.

a. Front b. Back

Step 11:

• Turn the dose knob until it stops and the icon is shown in the dose window. The icon is equal to a full dose (0.6 mL).

Step 12:

a. Insert the needle into your skin.

b. Inject the medicine by pushing the dose knob in until it stops. Hold the dose knob in and slowly count to 5. The icon must be shown in the dose window before removing the needle.

Step 13:

• Pull the needle out of your skin. A drop of medicine on the needle tip is normal. It will not affect your dose.

• Confirm the icon is in the dose window.

  If you see the icon in the dose window, you have received the full dose.

  If you do not see the icon in the dose window, insert the needle back into your skin and finish your injection. Do not redial the dose.

  If you still do not think you received the full dose, do not start over or repeat the injection. See “Troubleshooting” section for more information or call 1-888-545-5972.

After your ZEPBOUND injection

Step 14:

• If you see blood after you pull the needle out of your skin, lightly press the injection site with gauze or a cotton ball.

  Do not rub the injection site.

Step 15:

• Carefully replace the outer needle shield.

Step 16:

• Unscrew the capped needle and put the needle in a sharps container (see “Disposing of ZEPBOUND multi-dose prefilled pen (KwikPen) and needles” section).

  Do not store the KwikPen with the needle attached to prevent leaking, blocking the needle, and air from entering the KwikPen.

Step 17:

• Replace the KwikPen cap.

  Do not store the KwikPen without the pen cap attached.

Storage and handling

Unused KwikPens:

• Store your unused KwikPen in the refrigerator between 2°C and 8°C.
• KwikPens may be used until the expiration date printed on the label if the unused KwikPen has been stored in the refrigerator.
• Do not freeze your KwikPen. Throw away the KwikPen in a sharps disposal container if it has been frozen.

Used KwikPens:

• You may store your used KwikPen at room temperature up to 30°C for up to 30 days.
• Keep away from heat and light.
• Throw away the KwikPen 30 days after first use in a sharps disposal container even if the KwikPen has medication left in it.
• Throw away the KwikPen after receiving the 4 weekly doses contained in the pen in a sharps disposal container. Attempting to inject any leftover medicine could result in an incomplete dose even though the KwikPen still has medication left in it.

Keep your KwikPen, needles, sharps container and all medicines out of the sight and reach of children.

Disposing of ZEPBOUND multi-dose prefilled pen (KwikPen) and needles

• Put your used pen needles in a sharps disposal container right away after use.
• Do not throw away loose pen needles in your household trash.
• ZEPBOUND multi-dose prefilled pen (KwikPen) contains 4 doses. Discard your KwikPen in a sharps disposal container after using all 4 doses – one dose per week for 4 weeks. Put all used KwikPens into a puncture-resistant (sharps) container once all the doses have been used. There may be some medicine still left in the pen after the 4 weekly doses were given.

• If you do not have a sharps disposal container, you may use a household container that is:

  • made of a heavy-duty plastic,
  • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
  • upright and stable during use,
  • leak-resistant, and
  • properly labeled to warn of hazardous waste inside the container.
• When your sharps disposal container is almost full, follow your community guidelines for the right way to dispose of it. There may be local laws about how you should throw away used needles and syringes. Talk to your healthcare professional about how to dispose of your sharps container.

• Do not recycle your used sharps disposal container.

  Troubleshooting

• If you cannot remove the KwikPen cap, gently twist the KwikPen cap back and forth, and then pull the KwikPen cap straight off.

• If the dose knob is hard to push:

  • pushing the dose knob slower will make it easier to inject.
  • your needle may be blocked. Put on a new pen needle and prime the KwikPen.
  • you may have dust, food, or liquid inside the KwikPen. Throw the KwikPen away in a sharps disposal container and get a new KwikPen.

• If the KwikPen prevents you from turning the dose knob until the is in the dose window:

  • Throw away the KwikPen, including the unused medicine, in a sharps disposal container. There may not be enough medicine left in the KwikPen to give a full dose. Do not attempt to inject the leftover medicine.

Additional Information:

Scan this QR code or visit www.zepbound.ca for more information on how to use ZEPBOUND including an instructional video.

For more information, please contact Eli Lilly Canada Incorporated at 1-888-545-5972 or visit the website at www.lilly.ca.

Eli Lilly Canada Inc.

P.O. Box 73

Toronto, ON M5X 1B1

ZEPBOUND^® and KwikPen^® are registered trademarks of Eli Lilly and Company, its subsidiaries or affiliates.

Copyright © 2025, 2026, Eli Lilly and Company. All rights reserved.

Date of Authorization:

B4.0-NL-ZEPKP-0003-CA-IFU-20260604

Medication Calendar

Use ZEPBOUND 1 time a week.

Write the day of the week you choose to inject. Inject on this day each week (Example: Monday).

I inject my weekly 0.6 mL dose on the dates below.

(Month/Day)

(Month/Day)

(Month/Day)

(Month/Day)