0.4% Lidocaine Hydrochloride and 5% Dextrose Injection: Uses, Side Effects and Dosage

What is 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection used for?

0.4% Lidocaine Hydrochloride and 5% Dextrose Injection is used to treat abnormally fast heart rhythms that may occur during:

• heart surgery or other procedures
• a heart attack or other conditions

How does 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection work?

0.4% Lidocaine Hydrochloride and 5% Dextrose Injection is an antiarrhythmic drug. It works to reduce the number of heartbeats per minute and helps return the heartbeat to normal.

What are the ingredients in 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection?

Medicinal ingredients: lidocaine hydrochloride and dextrose

Non-medicinal ingredients: Sodium hydroxide and water for injection.

0.4% Lidocaine Hydrochloride and 5% Dextrose Injection comes in the following dosage forms:

Solution: 4 mg/mL of lidocaine hydrochloride and 50 mg/mL of dextrose.

Do not use 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection if :

• you are allergic or sensitive to lidocaine hydrochloride, to any of the nonmedicinal ingredients in 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection or other local anaesthetics (e.g. prilocaine, mepivacaine or bupivacaine);
• you have a heart condition such as, Adams-Stokes syndrome, or severe degrees of sinoatrial, atrioventricular or intraventricular block.
• you have supraventricular arrhythmias.
• you have severe myocardial depression.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection. Talk about any health

conditions or problems you may have, including if you:

• have a slow heartbeat.
• have low levels of potassium in your blood.
• have been taking a drug called digitalis.
• have epilepsy.
• have low blood pressure.
• have problems with your heart, liver or kidneys.
• have been diagnosed with porphyria.
• are experiencing severe shock.

• are pregnant or plan to become pregnant.

• are breastfeeding or planning to breastfeed.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection:

• Antiarrhythmic drugs used to treat heart problems such as; mexiletine, amiodarone.
• Cimetidine used for stomach problems.
• Fluvoxamine used to treat depression.
• Beta-blockers, used to treat heart problems, such as; metoprolol, nadolol, propranolol.
• Drugs used to treat epilepsy and seizures such as; carbamazepine, phenobarbital, phenytoin, primidone.

How to take 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection:

• 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection will be given as an intravenous injection by a healthcare professional.
• Your heart rate and blood pressure will be monitored while you are receiving 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection.
• Your healthcare professional may give you one single injection of 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection. Depending on your condition, you may need a continuous infusion of 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection.

Usual dose:

Your healthcare professional will determine your dose based on your individual needs.

Overdose:

Serious side effects can occur if you are given too much 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection. Early signs that you have been given too much 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection include:

• numbness of the lips and around the mouth,
• lightheadedness or dizziness,
• blurred vision,
• hearing problems and/ or ringing in the ears.

What are possible side effects from using 0.4% Lidocaine Hydrochloride and 5% Dextrose

Injection?

These are not all the possible side effects you may have when taking 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection. If you experience any side effects not listed here, tell your healthcare professional.

Side effects may include:

• nausea, vomiting
• dizziness, lightheadedness
• drowsiness
• sensations of heat, cold or numbness
• sensitivity to sounds, ringing in the ears

Serious side effects and what to do about them

If you think you, or a person you are caring for, have taken too much 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Storage:

Store at room temperature (15 - 25ºC).

Keep out of reach and sight of children.

If you want more information about 0.4% Lidocaine Hydrochloride and 5% Dextrose Injection:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada Drug Product Database

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

• website:(https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website http://www.baxter.ca, or by calling 1-888-719-9955.

Last Revised: JUL 21, 2025