Dom-Ciprofloxacin: Uses, Side Effects and Dosage

Serious Warnings and Precautions

What is Dom-CIPROFLOXACIN used for?

Dom-CIPROFLOXACIN is used to treat certain types of bacterial infections.

Antibacterial drugs like Dom-CIPROFLOXACIN treat only bacterial infections. They do not treat viral infections such as the common cold. Although you may feel better early in treatment, Dom-CIPROFLOXACIN should be taken exactly as directed. Misuse or overuse of Dom-CIPROFLOXACIN could lead to the growth of bacteria that will not be killed by Dom-CIPROFLOXACIN (resistance). This means that Dom-CIPROFLOXACIN may not work for you in the future. Do not share your medicine.

How does Dom-CIPROFLOXACIN work?

Dom-CIPROFLOXACIN is an antibiotic that kill the bacteria causing the infection.

What are the ingredients in Dom-CIPROFLOXACIN?

Medicinal ingredients: ciprofloxacin hydrochloride.

Non-medicinal ingredients: Colloidal silicon dioxide, corn starch, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide.

Dom-CIPROFLOXACIN come in the following dosage forms:

Dom-CIPROFLOXACIN 100 mg, are white, oval shaped, film coated tablets debossed with ‘R’ on one side and ‘125’ on other side.

Dom-CIPROFLOXACIN 250 mg, are white, oval shaped, film coated tablets debossed with ‘R’ on one side and ‘126’ on other side.

Dom-CIPROFLOXACIN 500 mg, are white, oval shaped, beveled edge film coated tablets debossed with ‘R’ on one side and ‘127’ on other side.

Dom-CIPROFLOXACIN 750 mg, are white, modified capsule shaped, film coated tablets debossed with ‘R’ on one side and ‘128’ on other side.

Do not use Dom-CIPROFLOXACIN if:

• you are allergic to ciprofloxacin or other quinolone antibiotics.
• you are allergic to any other ingredient in these products (see “What are the ingredients in Dom-CIPROFLOXACIN?”).
• you are taking tizanidine (ZANAFLEX®). Side effects such as drowsiness, sleepiness and low blood pressure may occur.
• are currently taking agomelatinea. Agomelatine concentrations may increase and may cause further side effects such as liver toxicity.

^a Currently not marketed in Canada

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Dom-CIPROFLOXACIN. Talk about any health conditions or problems you may have, including if you:

• have a history of seizures.
• have an irregular heart rhythm (such as QT prolongation).
• have low potassium blood levels.
• have liver or kidney disease or damage.

• are pregnant, planning to become pregnant, breast feeding or planning to breast feed.

• are less than 18 years of age.
• have a history of tendon problems (such as pain, swelling or rupture of a tendon) related to the use of quinolone antibiotics.
• have myasthenia gravis (a muscle disease).

Other warnings you should know about:

Blood Sugar Changes

Medicines like Dom-CIPROFLOXACIN can cause blood sugar levels to rise and drop in patients with diabetes. Serious cases of hypoglycemia (low blood sugar levels) that caused coma or death have been seen with medicines like Dom-CIPROFLOXACIN. If you have diabetes, check your blood sugar levels often while taking Dom-CIPROFLOXACIN.

While taking Dom-CIPROFLOXACIN:

• Avoid too much sunlight or artificial ultraviolet light (such as sunlamps).
• Contact your doctor if a sunburn or rash occurs.

• Do not drive or use machinery if you feel dizzy or lightheaded.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with Dom-CIPROFLOXACIN:

• Theophylline or VIDEX^® (didanosine) chewable/buffered tablets or pediatric powder. Serious and fatal reactions have been reported in patients receiving ciprofloxacin, including Dom-CIPROFLOXACIN and theophylline.
• Antacids, multivitamins, and other dietary supplements containing magnesium, calcium, aluminum, iron or zinc (see “How to take Dom-CIPROFLOXACIN:”).
• Antidiabetic agents (such as glyburide, glibenclamide, glimepiride, insulin); the combination of any of these agents with ciprofloxacin may cause lower blood sugar.
• Nonsteroidal Anti-Inflammatory Drugs (NSAIDS).
• Caffeine (such as coffee) and other xanthine derivatives (such as pentoxifylline).
• Certain heart medications known as antiarrhythmics (such as quinidine, procainamide, amiodarone, sotalol).
• Other medications including:
• oral anticoagulants (like warfarin and acenocoumarol),
• phenytoin, duloxetine, methylxanthines, sevelamer,
• sucralfate, clozapine, ropinirole, lidocaine, sildenafil, probenecid,
• methotrexate, metoclopramide, cyclosporine, lanthanum carbonate, zolpidem.

How to take Dom-CIPROFLOXACIN:

• Dom-CIPROFLOXACIN should be taken as prescribed at almost the same times each day with food or on an empty stomach.

• Dom-CIPROFLOXACIN should not be taken with dairy products (like milk or yogurt) or calcium-fortified juices alone; however, Dom-CIPROFLOXACIN may be taken with a meal that contains these products (see “The following may interact with Dom-CIPROFLOXACIN:”).
• You should avoid excessive caffeine consumption while taking Dom-CIPROFLOXACIN.
• You should drink lots of water while taking Dom-CIPROFLOXACIN.
• Swallow the Dom-CIPROFLOXACIN tablets whole, with water as needed. DO NOT SPLIT, CRUSH, OR CHEW THE TABLET.
• After use the graduated measuring spoon should be cleaned under running water with detergent and dried thoroughly afterwards.
• If you are taking the following medicines, take them at least 2 hours before or 6 hours after Dom-CIPROFLOXACIN:
• antacids or mineral supplements containing magnesium or aluminium
• sucralfate
• supplements containing iron or zinc
• any product (supplement or food) with more than 800 mg calcium
• Do not use Dom-CIPROFLOXACIN for another condition or give it to others.

You should take Dom-CIPROFLOXACIN for as long as your doctor prescribes it, even after you start to feel better. Stopping an antibiotic too early may result in failure to cure your infection.

Usual dose:

Your doctor (healthcare provider) will tell you how much of the medicine to take and for how long.

This information does not take the place of discussions with your doctor or health care professional about your medication or treatment.

Overdose:

Missed Dose:

Should you forget to take it at the usual time, you may take your dose later in the day. Do not take more than two doses of CIPRO or, per day, even if you missed a dose.

What are possible side effects from using Dom-CIPROFLOXACIN?

All medicines, including Dom-CIPROFLOXACIN can cause side effects, although not everyone gets them.

These are not all the possible side effects you may feel when taking Dom-CIPROFLOXACIN.

If you have any side effects not listed here or if conditions worsen or do not improve then:

• contact your healthcare professional.
• see the “To help avoid side effects and ensure proper use,…” section. Stop taking Dom-CIPROFLOXACIN and contact your doctor if:

• you have symptoms of an allergic reaction such as:

  • rash, hives, blistering or other skin reaction
  • swelling of the face, lips, tongue or throat
  • difficulty breathing
  • irregular or rapid heartbeat, or fainting spells
• you have sunburn-like skin reaction when exposed to sunlight or ultraviolet light.

• you have pain, swelling or rupture of a tendon. You should:

  • rest
  • avoid physical exercise

• you have neuropathy (damage to the nerves) with symptoms such as:

  • pain, burning, tingling, numbness or weakness

• you have severe diarrhea (bloody or watery) with or without:

  • fever
  • stomach pain or tenderness

You may have Clostridium difficile colitis (bowel inflammation). See your doctor right away.

1. f)

   you have mental problems such as:

   • confusion, headache, shaking
   • hallucinations, depression, agitation
   • difficulty sleeping, anxiety, nervousness, suicidal thought

Contact your doctor if you have suicidal thoughts.

Other side effects include:

• your eyesight worsens or changes. See your doctor or eye specialist right away.
• nausea, dizziness, unsteady walk
• gas, cramping, feeling unwell,
• loss of hearing, problems of smell and taste, loss of appetite
• migraine, sweating

• worsening of myasthenia gravis (a muscle disease) with symptoms such as:

  • weakness
  • difficulty walking, swallowing, drooping eyelids

Do not use Dom-CIPROFLOXACIN if you have this condition.

Self-Limiting Side Effects:

• feeling lightheaded
• insomnia (difficulty sleeping)
• nightmares

If any of these affect you severely, tell your doctor or pharmacist.

Serious Side Effects and What to do About Them

Serious Side Effects and What to do About Them

Serious Side Effects and What to do About Them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

Storage:

Tablets: Store at controlled room temperature between 15°C and 25°C.

Keep out of reach and sight of children.

If you want more information about Dom-CIPROFLOXACIN:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website, or by contacting Dominion Pharmacal at 1-888-550-6060.

Last revised: September 10, 2019