Jamp Colesevelam: Uses, Side Effects and Dosage

ABOUT THIS MEDICATION

What the medication is used for:

• JAMP Colesevelam may be prescribed on its own (called monotherapy) in addition to a diet low in fat and cholesterol when treatment with a statin (a class of cholesterol-lowering medicines that work in the liver) is inadequate.
• JAMP Colesevelam may be used together with a statin (called combination therapy) and the diet low in fat and cholesterol when patients are not appropriately controlled by the statin on its own.

What it does:

Taking JAMP Colesevelam helps to lower the level of cholesterol in your blood. Your doctor should only give you JAMP Colesevelam if a diet low in fat and cholesterol did not work well enough on its own.

JAMP Colesevelam works in your intestinal system by binding bile acids produced by your liver and carrying the bile acids out of your body with your feces. This prevents your body from recycling the bile acids from your intestines in the usual way. Without the recycling process, your liver has to make additional bile acids. Your liver uses cholesterol from your blood to do this, which lowers the level of cholesterol in your blood.

When it should not be used:

Do not take JAMP Colesevelam

• if you are allergic (hypersensitive) to colesevelam or to any of the other ingredients of JAMP Colesevelam
• if you have a blockage in your intestines or bile ducts (tubes that carry bile)

What the medicinal ingredient is:

Colesevelam hydrochloride

What the non-medicinal ingredients are:

Ammonium hydroxide, colloidal silicon dioxide, hypromellose, iron oxide black, magnesium stearate, microcrystalline cellulose, polyethylene glycol, propylene glycol and shellac.

What dosage forms it comes in:

Tablets: 625 mg

WARNINGS AND PRECAUTIONS

BEFORE you use JAMP Colesevelam talk to your doctor or pharmacist if:

• your triglyceride levels (a blood fat) are greater than

  3.4 mmol / L

• you have difficulty in swallowing, or have a major stomach or intestinal disorder
• you are taking another medication called cyclosporine (a medicine used to suppress the immune system)
• you are taking antidiabetic treatments
• you are taking the oral contraceptive pill
• you are taking anticoagulant therapy
• you suffer from constipation, as JAMP Colesevelam may induce or worsen this condition. This is especially important for patients with coronary heart disease and angina pectoris

• you are pregnant, planning on becoming pregnant or are breastfeeding

• you have any allergies to this drug or its ingredients or components of the container

INTERACTIONS WITH THIS MEDICATION

To ensure that the effectiveness of the following medications is not affected, it is important that you take the following medications at least 4 hours before taking JAMP Colesevelam.

Drugs that may interact with JAMP Colesevelam include:

• Anticoagulant therapy (medicines, such as warfarin, used to thin blood)
• Thyroid replacement therapy (medicines, such as thyroxine or levothyroxine, used to treat low thyroid hormone levels)
• Oral contraceptives (medicines to prevent pregnancy)
• Verapamil (a medicine used to treat high blood pressure)
• Antidiabetic medications (medicines, such as pioglitazone, repaglinide, glyburide metformin and insulin used to treat diabetes)
• Anti-epileptic medicines (medicines, such as phenytoin, used to treat epilepsy).
• Cyclosporine (a medicine used to suppress the immune system).

If you are going to take JAMP Colesevelam and one of these medicines, your doctor may want to do tests to make sure that JAMP Colesevelam does not interfere with these medicines.

IMPORTANT: PLEASE READ

Additionally, if you have any condition that could cause you to have a deficiency of vitamins A, D, E or K, your doctor may want to check your vitamin levels periodically while you are taking JAMP Colesevelam. If necessary, your doctor may advise you to take vitamin supplements.

PROPER USE OF THIS MEDICATION

Missed Dose:

You may take a missed dose with a later meal, but do not take a double dose of JAMP Colesevelam to make up for missed doses.

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

Before starting therapy with JAMP Colesevelam, you should be advised to follow a cholesterol-lowering diet and you should continue this diet during treatment.

Take JAMP Colesevelam with a meal.

Swallow the tablets with liquid.

Always take JAMP Colesevelam exactly as your doctor has instructed you. You should check with your doctor or pharmacist if you are unsure. If you will be taking another medicine along with JAMP Colesevelam it is possible that your doctor will advise you to take this other medicine at least 4 hours prior to taking JAMP Colesevelam.

If you take a drug called cyclosporine, please ensure to take it with JAMP Colesevelam in a consistent pattern over the day; either always together or always separate for a set number of hours.

Usual dose:

Monotherapy:

The usual starting dose for JAMP Colesevelam is 3 tablets taken twice a day with meals or 6 tablets a day with a meal. Your doctor may increase your dose to a maximum of 7 tablets per day.

Combination therapy:

The usual dose for JAMP Colesevelam, when used with a statin, is 4 to 6 tablets a day. The maximum recommended dose is 6 tablets per day. Your doctor may tell you to take the JAMP Colesevelam dose either once a day or twice a day.

JAMP Colesevelam should be taken with a meal. The dosing of the statin should follow the instructions for that particular statin. The two medicines may be taken at the same time or at separate times according to what your doctor has prescribed.

Overdose:

Please contact your doctor. Constipation or bloating could occur.

If you think you, or a person you are caring for, have taken too much JAMP Colesevelam, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X

(1-844-764-7669) immediately, even if there are no signs or symptoms.

Like all medicines, JAMP Colesevelam can cause side effects, although not everybody gets them.

The following side effects have been reported in patients taking colesevelam:

Constipation, flatulence (gas), diarrhea, indigestion, muscle pain, abdominal pain, abnormal stools, feeling sick (nausea), headache, raised levels of triglycerides (fats) in your blood, raised levels of liver enzymes in your blood.

You may notice that hemorrhoids get worse.

Side effects were usually mild or moderate in intensity.

SERIOUS SIDE EFFECTS AND WHAT TO DO ABOUT THEM

This is not a complete list of side effects. For any unexpected effects while taking JAMP Colesevelam, contact your doctor or pharmacist.

IMPORTANT: PLEASE READ

HOW TO STORE IT

• Keep out of reach and sight of children.
• Store between 15-30°C.
• Protect from moisture.
• Do not use after the expiry date.

MORE INFORMATION

If you want more information about JAMP Colesevelam:

• Talk to your healthcare professional

• Find the full Product Monograph that is prepared for healthcare professionals and includes the Consumer Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); or by calling 1-866-399-9091.

  1310 rue Nobel

  Boucherville, Québec

  J4B 5H3, Canada

Last revised: MAR 20, 2026

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.