Patient Medication Information: uses, side effects, how to take - Jamp Imipramine
What is JAMP Imipramine used for?
JAMP Imipramine is used to relieve the symptoms of depression (feeling sad, a change in appetite or weight, difficulty concentrating or sleeping, feeling tired, headaches, unexplained aches and pain).
How does JAMP Imipramine work?
JAMP Imipramine is an antidepressant drug that belongs to a group of medicines called tricyclic antidepressant drugs. It is not known exactly how JAMP Imipramine works. It is thought to increase the concentration of certain chemicals in the brain which can help with the symptoms of depression.
What are the ingredients in JAMP Imipramine ?
Medicinal ingredient: imipramine hydrochloride.
Non-medicinal ingredients: Colloidal silicon Dioxide, Dicalcium phosphate anhydrous, FD&C Yellow No. 6 Aluminum Lake, Hypromellose, Iron oxide black, Iron oxide red, Lactose anhydrous, Magnesium stearate, Polyethylene glycol, Povidone, Talc, Titanium Dioxide
Serious Warnings and Precautions
Self-harm or suicide:
- Antidepressants, such as JAMP Imipramine, may increase the risk of suicidal thoughts and actions.
- If you have thoughts of harming or killing yourself at any time, tell your healthcare professional or go to a hospital right away. Close observation by a healthcare professional is necessary in this situation.
JAMP Imipramine comes in the following dosage forms:
Tablets: 10 mg, 25 mg, 50 mg, and 75 mg.
Do not use JAMP Imipramine if:
- you are allergic to imipramine hydrochloride, or any of the ingredients in JAMP Imipramine.
- you are allergic to tricyclic antidepressants that belong to the dibenzazepine group. Talk to your healthcare professional if you are not sure.
- you are taking or have taken monoamine oxidase inhibitors (MAOIs) within the last 14 days.
- you have recently had a heart attack.
- you are in heart failure.
- you have glaucoma (increased eye pressure).
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take JAMP Imipramine. Talk about any health conditions or problems you may have, including if you:
have heart problems including:
- blood clots that form in the blood vessels or arteries of the heart,
- angina,
- heart failure,
- disorders affecting heart rate, rhythm or conduction and
- heart or blood vessel disease.
- have trouble urinating.
- have an enlarged prostate.
- have thoughts of harming or killing yourself.
- suffer from epilepsy or seizures.
are pregnant, think you might be pregnant or planning to become pregnant. JAMP Imipramine should not be used during the first trimester of pregnancy.
- are breastfeeding or are planning to breastfeed.
- are 65 years of age or older.
have one of the following rare hereditary diseases:
- Galactose intolerance
- Lapp lactase deficiency
- Glucose-galactose malabsorption
Because lactose is a non-medicinal ingredient in JAMP Imipramine.
Other warnings you should know about:
Angle-closure Glaucoma: JAMP Imipramine can cause an acute attack of glaucoma. Having your eyes examined before you take JAMP Imipramine could help identify if you are at risk of having angle-closure glaucoma. Seek immediate medical attention if you experience:
- eye pain,
- changes in vision,
- swelling or redness in or around the eye.
Laboratory Tests: Tell your healthcare professional if you develop a fever and sore throat while taking JAMP Imipramine. Your healthcare professional will do blood tests. These tests will monitor your white blood cell count.
Serotonin toxicity (also known as Serotonin syndrome): JAMP Imipramine can cause Serotonin toxicity, a rare but potentially life-threatening condition. It can cause serious changes in how your brain, muscles and digestive system work. You may develop Serotonin toxicity if you take JAMP Imipramine with certain antidepressants or migraine medications.
Serotonin toxicity symptoms include:
- fever, sweating, shivering, diarrhea, nausea, vomiting;
- muscle shakes, jerks, twitches or stiffness, overactive reflexes, loss of coordination;
- fast heartbeat, changes in blood pressure;
- confusion, agitation, restlessness, hallucinations, mood changes, unconsciousness, and coma.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements, or alternative medicines.
The following may interact with JAMP Imipramine:
alcohol beverages.
- other medicines used to treat depression.
- anticholinergic agents, used to relieve stomach cramps, spasms and travel sickness.
- cimetidine used to treat stomach ulcers.
- medicines used to treat high blood pressure such as guanethidine.
- norepinephrine used to treat low blood pressure.
- epinephrine used to treat anaphylaxis, cardiac arrest, and severe asthma attacks.
methylphenidate used to treat attention-deficit / hyperactivity disorder (ADHD).
Serious Drug Interactions
Do not take JAMP Imipramine if you are taking a monoamine oxidase inhibitor (MAOI), or if you have taken one in the last 14 days as this can cause serious side effects.
How to take JAMP Imipramine:
- Take JAMP Imipramine exactly as your healthcare professional tells you to. Talk to your healthcare professional if you are not sure.
- Swallow the tablets whole with a glass of water.
Usual dose:
Your healthcare professional will determine the dose that is right for you and how often you should take it. Your dose will depend on your age and if you have any heart problems. Based on how you respond to JAMP Imipramine and your tolerability, your healthcare professional may change your dose.
Overdose:
Signs of an overdose may include:
- confusion
- disturbed concentration
- visual hallucinations
- restlessness
- overactive reflexes
- muscle rigidity
- vomiting
- high fever
- drowsiness
- hypothermia
- heart rhythm problems
Missed Dose:
If you miss a dose of JAMP Imipramine, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your next scheduled dose. Do not take two doses at the same time to make up for the missed dose.
If you think you, or a person you are caring for, have taken too much JAMP Imipramine, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms.
What are possible side effects from using JAMP Imipramine?
These are not all the possible side effects you may have when taking JAMP Imipramine. If you experience any side effects not listed here, tell your healthcare professional.
Side effects may include:
- dry mouth
- swelling of salivary glands
- constipation
- diarrhea
- nausea, vomiting
- stomach pain, stomach cramps
- unpleasant taste in the mouth
- sore mouth
- black tongue
- change in appetite
- weight gain or loss
- fever
- weakness
- tiredness
- headache
- falls
- impaired coordination
- shaking
- drowsiness
- dizziness
- dilated pupils
- change in libido
- inability to have or maintain an erection
- swelling of testicles
- problem emptying your bladder
- frequent urination
- itching
- sweating more than usual
- flushing
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
Only if severe | In all cases | ||
| RARE | |||
Angle-closure Glaucoma: eye pain, changes in vision, and swelling or redness in or around the eye | √ | ||
Serotonin toxicity: a reaction which may cause feelings of agitation or restlessness, flushing, muscle twitching, involuntary eye movements, heavy sweating, high body temperature (> 38°C), or rigid muscles | √ | ||
| UNKNOWN | |||
Agranulocytosis (decrease in white blood cells): frequent infection with fever, chills, sore throat | √ | ||
Bone marrow depression: easy bruising, bleeding, nose bleeds, bleeding gums, red spots on the skin, fever and chills, rash, extreme fatigue, pale skin and lips | √ | ||
Changes in feelings and behaviours: confusion, hallucinations (seeing or hearing things that are not really there), problems with attention, delusions, anxiety, restlessness, excitement, trouble sleeping, nightmares, extremely elevated And excitable mood, memory problems | √ | ||
Edema: unusual swelling of the arms, hands, legs, feet, ankles, face or airway passages | √ | ||
| Eosinophilia (increased numbers of certain white blood cells): abdominal pain, rash, weight loss, wheezing | √ | ||
Extrapyramidal reactions: muscle stiffness, body spasms, upward eye rolling, exaggeration of reflexes, drooling, difficulty moving how and when you want, mask-like face (appears to lack emotion), tremors or dragging feet as you walk, difficultly swallowing, a feeling of restlessness, or inability to remain motionless | √ | ||
| Heart rhythm problems: irregular heartbeat, fast heartbeat, shortness of breath, fainting, loss of consciousness | √ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
Only if severe | In all cases | ||
| Hormonal changes: breast enlargement in men, breast enlargement and abnormal milk production in women | √ | ||
Hypertension (high blood pressure): shortness of breath, fatigue, dizziness or fainting, chest pain or pressure, swelling in your ankles and legs, bluish colour to your lips and skin, racing pulse or heart palpitations | √ | ||
Hypotension (low blood pressure): dizziness, fainting, lightheadedness, blurred vision, nausea, vomiting, fatigue (may occur when you go from lying or sitting to standing up) | √ | ||
Increased or decreased blood sugar: frequent urination, thirst, hunger, shakiness, sweating and chills, irritability, confusion, dizziness | √ | ||
Jaundice (buildup of bilirubin in the blood): yellowing of the skin and eyes, dark urine, light- colored stool, or itching all over your body | √ | ||
Mania: elevated or irritated mood, decreased need for sleep, racing thoughts, uneasiness | √ | ||
| Myocardial infarction (heart attack): pressure or squeezing pain between the shoulder blades, in the chest, jaw, left arm or upper abdomen, shortness of breath, dizziness, fatigue, lightheadedness, clammy skin, sweating, indigestion, anxiety, feeling faint and possible irregular heartbeat | √ | ||
| Palpitations (fast-beating, fluttering or pounding heart): skipping beats, beating too fast, pounding, fluttering rapidly | √ | ||
| Paralytic ileus (muscles that move food through the intestines are paralyzed): new or worsening constipation, nausea, vomiting, dehydration, gas, or abdominal pain | √ | ||
Paresthesia (pins and needles): numbness, weakness, tingling, burning; occurs in the arms, hands, legs or feet. | √ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
Only if severe | In all cases | ||
| Peripheral neuropathy (damage to the nerves outside the spinal cord and the brain): numbness or tingling sensation in the hands or feet | √ | ||
Seizures (fits): uncontrollable shaking with or without loss of consciousness | √ | ||
Skin disorders Photosensitivity (sensitivity to sunlight): itchy, dry, red skin when exposed to sunlight Petechiae: pinpoint, red or purple round spots that appear on the skin Urticaria: skin with red spots which burn, itch or sting | √ | ||
Stroke: sudden numbness or weakness of your arm, leg or face, especially if only on one side of the body; sudden confusion, difficulty speaking or understanding others; sudden difficulty in walking or loss of balance or coordination; suddenly feeling dizzy or sudden severe headache with no known cause | √ | ||
| Thrombocytopenia (low blood platelets): bruising or bleeding for longer than usual if you hurt yourself, fatigue and weakness | √ | ||
Tinnitus: ringing, buzzing, clicking or hissing in the ears | √ | ||
Withdrawal symptoms: feeling or being sick, stomach discomfort, diarrhea, vomiting, difficulty sleeping, nervousness, anxiety, headache, irritability | √ | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Storage:
Store at room temperature, 15 - 30°C. Keep out of reach and sight of children.
If you want more information about JAMP Imipramine
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug- products/drug-product-database.html); or by calling 1-866-399-9091.
JAMP Pharma Corporation
1310 rue Nobel
Boucherville, Quebec
J4B 5H3, Canada
Last Revised: MAR 14, 2024
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
- Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health- products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
- Calling toll-free at 1-866-234-2345.
NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.