Patient Medication Information: uses, side effects, how to take - Jamp Pentoxifylline SR
What is JAMP Pentoxifylline SR used for?
JAMP Pentoxifylline SR is used in adults to treat the symptoms of long-term blood flow problems in the arms and legs. It helps relieve aching, cramping or tiredness when walking and tropic ulcers (ulcers that occur around the ankle or on arms).
How does JAMP Pentoxifylline SR work?
Pentoxifylline is a xanthine derivative. It belongs to a group of medicines called vasoactive drugs. Pentoxifylline helps blood flow more easily to the arms and legs. This increases the amount of oxygen that can be delivered by the blood when the muscles need more.
What are the ingredients in JAMP Pentoxifylline SR?
Medicinal ingredient: Pentoxifylline
Non-medicinal ingredients: FD&C Red No. 3 aluminum lake, hydroxyethyl cellulose, hypromellose, macrogol, magnesium stearate, povidone, talc and titanium dioxide.
JAMP Pentoxifylline SR comes in the following dosage forms:
Extended-Release Tablets: 400 mg
Do not use JAMP Pentoxifylline SR if:
- You are sensitive to pentoxifylline or other xanthine products (caffeine, theophylline and theobromine) or to any of the other ingredients of JAMP Pentoxifylline SR.
- You have heart problems.
- You have coronary artery disease (hardened arteries) and in your healthcare professional’s opinion, stimulation to the heart could be harmful.
- You have bleeding problems (hemorrhage) in your brain or the retina of your eye.
- You have or recently had a stomach or intestinal ulcer.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take JAMP Pentoxifylline SR. Talk about any health conditions or problems you may have, including if you:
- have liver or kidney problems.
- have low or unstable blood pressure.
are pregnant or planning to become pregnant.
- are breastfeeding or are planning to breastfeed. JAMP Pentoxifylline SR is excreted in into breastmilk.
- have severe cardiac arrhythmias. Your healthcare professional may monitor you while you take JAMP Pentoxifylline SR.
- have recently had surgery. Your healthcare professional may perform examinations for bleeding.
- are taking warfarin. Your healthcare professional may monitor you while you take JAMP Pentoxifylline SR.
- are 65 years of age or older.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with JAMP Pentoxifylline SR:
- Antihypertensive agents used to treat high blood pressure
- Sympathomimetics used to treat cardiac arrest, low blood pressure
- Theophylline used to treat wheezing or difficulty in breathing
- Antibiotics such as erythromycin
- Hypoglycemic agents used for diabetes
- Anticoagulants such as warfarin
- Antacids used to treat digestive problems
- Cimetidine used to treat stomach ulcers and heart burn
- Medicines called CYP1A2 inhibitors, such as ciprofloxacin and fluvoxamine
How to take JAMP Pentoxifylline SR:
- Take JAMP Pentoxifylline SR exactly as your healthcare professional has told you. Check with your healthcare professional if you are not sure.
Take JAMP Pentoxifylline SR tablets after a meal. Swallow the tablets whole with water.
- Continue to take your medicine even if you do not feel better. It may take a number of weeks for your medicine to start working.
Usual dose:
Adults (18 to 64 years of age):
- The usual starting dose is 400 mg two times a day.
- The usual maintenance dose is 400 mg two or three times a day.
- The maximum daily dose is 400 mg three times a day.
Your healthcare professional may give you a lower dose of 400 mg once a day if you
- have problems with your kidneys.
- Your healthcare professional will decide on the dose that is best for you. Based on how you respond and how you tolerate your medicine, your healthcare professional may change your dose.
Elderly (65 years of age or older): Your healthcare professional will decide on the dose that is best for you. Based on how you respond and how you tolerate your medicine, your healthcare professional may change your dose.
Overdose:
Symptoms of an overdose include flushing, low blood pressure, feeling sleepy, seizures, fever, and agitation.
| If you think you, or a person you are caring for, have taken too much JAMP Pentoxifylline SR, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms. |
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Missed Dose:
If you forget to take a dose of this medication, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Go back to the regular dosing schedule. Do not take two doses at the same time to make up for a missed dose.
What are possible side effects from using JAMP Pentoxifylline SR?
These are not all the possible side effects you may have when taking JAMP Pentoxifylline SR. If you experience any side effects not listed here, tell your healthcare professional.
Side effects may include:
- nausea, vomiting, discomfort or bloating in the stomach and diarrhea
- dizziness or light-headedness
- headache
- flushing
- drowsiness or sleepiness
- agitation
- difficulty sleeping
- nose bleeds
- muscle pain
- backache
- leg pains
- fever
- weakness
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| UNCOMMON | |||
Allergic Reaction: difficulty swallowing or breathing, wheezing, drop in blood pressure, feeling sick to your stomach and throwing up, hives or rash, swelling of the face, lips, tongue or throat. | √ | ||
| Anemia (decreased number of red blood cells): fatigue, loss of energy, looking pale, shortness of breath, weakness | √ | ||
| Angina (not enough oxygen to the heart muscle): discomfort in the shoulder, arm, back, throat, jaw or teeth; pain or pressure in the chest | √ | ||
Arrhythmia (abnormal heart rhythms): rapid, slow or irregular heartbeat | √ | ||
| Aseptic meningitis (inflammation of the protective lining of the brain that is not caused by infection): confusion, fever, nausea, sudden headache or stiffness of your neck, sensitivity to light, vomiting | √ | ||
| Chest pain | √ | ||
| Cholecystitis (Inflammation of the gallbladder): fever, nausea, pain that radiates to your shoulder or back, severe pain in your upper right abdomen, vomiting | √ | ||
| Cholestasis (decrease in bile flow from the liver): jaundice (yellowing of the skin or whites of eyes), dark urine, light coloured stools | √ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| Dyspnea (shortness of breath) | √ | ||
| Edema: unusual swelling of the arms, hands, legs, feet and ankles, face or airway passages | √ | ||
| Eye problems: blurred vision, blind spots in the vision, watery eyes, itchy, red eyes with discharge, and swelling | √ | ||
Haemorrhage (blood loss from a ruptured blood vessel) | √ | ||
Heartburn (burning pain in the chest, just behind your breastbone): burning pain in the chest that usually occurs after eating and may occur at night; pain that worsens when lying down or bending over, bitter or acidic taste in the mouth | √ | ||
| Hepatitis (Inflammation of liver): Abdominal pain, fatigue, fever, itchiness, light coloured stool, trouble thinking clearly, yellowing of the skin | √ | ||
| Hypertension (high blood pressure): shortness of breath, fatigue, dizziness or fainting, chest pain or pressure, swelling in your ankles and legs, bluish colour to your lips and skin, racing pulse or heart palpitations | √ | ||
| Hypotension (low blood pressure): dizziness, fainting, light- headedness, blurred vision, nausea, vomiting, fatigue (may occur when you go from lying or sitting to standing up) | √ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| Increased levels of liver enzymes in the blood: dark urine, fatigue, loss of appetite, yellowing of the skin or eyes | √ | ||
Leukopenia (decreased white blood cells): infections, fatigue, fever, aches, pains and flu-like symptoms | √ | ||
| Pancytopenia (decreased red and white blood cells and platelets): low red blood cell count: paleness of the skin, fatigue, rapid heart rate, shortness of breath; low white blood cell count: fever, and symptoms of infection such as cough; low platelet count: bruising easily and heavy bleeding | √ | ||
| Purpura (bleeding under the skin): bruising | √ | ||
Seizures (fit): uncontrollable shaking with or without loss of consciousness | √ | ||
| Stomach pain or burning | √ | ||
Tachycardia (abnormally fast heartbeat): dizziness, light headedness, shortness of breath, racing heart | √ | ||
Thrombocytopenia (low blood platelets): bruising or bleeding for longer than usual if you hurt yourself, fatigue and weakness | √ | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
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Storage:
Store at room temperature, 15-30⁰C.
Keep out of reach and sight of children.
If you want more information about JAMP Pentoxifylline SR:
- Talk to your healthcare professional
- Find the full Product Monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); or by calling 1-866-399-9091.
1310 rue Nobel
Boucherville, Quebec
J4B 5H3, Canada
Last Approved: November 14, 2023