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Jeraygo: Uses, Side Effects and Dosage

Updated:
Facts
Status:
Prescription (Rx)
Strength:
12.5 mg, 25 mg
Active ingredient:
ATC code:

Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - Jeraygo

What JERAYGO is used for:

JERAYGO is used to treat high blood pressure (hypertension) in adults:

  • who are taking at least three other high blood pressure medicines and
  • whose blood pressure is not well controlled.

How JERAYGO works:

JERAYGO contains aprocitentan. Aprocitentan belongs to a group of medicines called endothelin receptor antagonists. JERAYGO works by helping to stop the blood vessels from tightening; as a result, the blood vessels relax and blood pressure is lowered.

The ingredients in JERAYGO are:

Medicinal ingredient: aprocitentan

Non-medicinal ingredients: croscarmellose sodium, hydroxypropyl cellulose, iron oxide black, iron oxide red, iron oxide yellow, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol, silica colloidal hydrated, talc, titanium dioxide, and triethyl citrate.

JERAYGO comes in the following dosage form:

Film-coated tablets: 12.5 mg and 25 mg

Do not use JERAYGO if:

  • you are allergic to aprocitentan or any of the other ingredients in JERAYGO (see The ingredients in JERAYGO are).
  • you are pregnant or think you might be pregnant.
  • you are breastfeeding.
  • you have severe liver disease.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take JERAYGO. Talk about any health conditions or problems you may have, including if you:

  • have fluid retention.
  • have heart disease.
  • have severe anemia.
  • have liver problems.
  • have kidney problems.
  • plan to become pregnant.
  • plan to breastfeed.
  • have heart failure.
  • are at high risk of developing heart failure or other heart and blood vessel problems.
  • have diabetes.
  • are obese (BMI of over 40 kg/m2).
  • are 75 years of age or older.

Other warnings you should know about:

A patient card is attached to the packaging of JERAYGO. It contains summarized information related to pregnancy and liver problems. Read this card and carry it with you at all times. Show it to any healthcare professional involved in your medical care.

Pregnancy:

  • If you take JERAYGO during pregnancy, it may harm your unborn baby. Your healthcare professional will discuss the risks with you.
  • Avoid becoming pregnant while you are taking JERAYGO. If you are able to get pregnant, you should use an effective birth control (contraception) method while you are taking JERAYGO and for one month after you stop treatment. Talk to your healthcare professional about the best birth control methods to use while you are taking JERAYGO.
  • Your healthcare professional may recommend that you take a pregnancy test before you start taking JERAYGO, every month while you are taking JERAYGO, and once in the month after you stop taking JERAYGO.
  • If you discover that you are pregnant, stop taking JERAYGO and tell your healthcare professional right away.

Fertility in men: JERAYGO may cause decreased sperm counts in males and may affect the ability to father a child. Tell your healthcare provider if being able to have children is important to you.

Liver problems: Like other medicines of the same class, JERAYGO might cause liver problems. Your healthcare professional should do blood tests to check that your liver is working properly before starting treatment with JERAYGO and may also check during your treatment. Tell your healthcare professional right away if you develop symptoms of liver problems including:

  • nausea (feeling sick) or vomiting
  • fever
  • pain in the upper right area of your abdomen (belly)
  • jaundice (yellowing of your skin or the whites of your eyes)
  • dark-coloured urine
  • itching of your skin
  • unusual tiredness or exhaustion
  • loss of appetite

Check-ups and testing:

During your treatment with JERAYGO, your healthcare professional will do check-ups and tests to monitor your health. This includes:

  • blood tests to monitor the health of your liver, heart and blood.

  • looking for signs of fluid retention. This is more likely to happen when you first start taking

    JERAYGO or in the first few weeks after your dose is increased. Tell your healthcare professional right away if you have:

    • unusual weight gain
    • trouble breathing
    • swelling of your arms, hands, feet, ankles or legs

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with JERAYGO:

No interactions with other medicines have been reported.

How to take JERAYGO:

  • Take JERAYGO exactly as your healthcare professional tells you.

  • Take it every day, with or without food.

  • Swallow the tablets whole.

Usual dose:

Take 1 tablet a day.

Overdose:

If you think you, or a person you are caring for, have taken too much JERAYGO, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

Missed dose:

If you miss a dose of JERAYGO, carry on with the next one at the usual time. Do not take 2 doses on the same day.

Possible side effects from using JERAYGO:

These are not all the possible side effects you may have when taking JERAYGO. If you experience any side effects not listed here, tell your healthcare professional.

Side effects with JERAYGO may include:

  • headache
  • Infected nose, sinuses or throat (upper respiratory tract infection)
  • flushing
  • low blood pressure

Serious side effects and what to do about them:

Frequency/Side Effect/SymptomTalk to your healthcare professionalStop taking this drug
Only if severeIn all casesand get immediate
medical help
Very common
Edema: swelling of the arms, hands, legs, feet and ankles, face or airway passages, weight gain✔
Common

Anemia (low number of red blood cells): fatigue, loss of energy, irregular heartbeats, pale

complexion, shortness of breath, weakness

✔
Uncommon
Allergic reaction: difficulty swallowing or breathing, wheezing, feeling sick to your stomach and throwing up, hives or rash, swelling of the face, lips, tongue or throat✔
Unknown
Liver problems: nausea (feeling sick) or vomiting, fever, pain in the upper right area of your abdomen (belly), jaundice (yellowing of your skin or the whites of your eyes), dark-coloured urine, itching of your skin, unusual tiredness or exhaustion, loss of appetite✔

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting side effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

  • Store in original package (bottle or blisters). Do not store above 25°C.
  • Keep the bottle closed tightly to protect from moisture.
  • Keep out of reach and sight of children.

If you want more information about JERAYGO:

  • Talk to your healthcare professional

  • Find the full product monograph that is prepared for healthcare professionals and includes the

    Patient Medication Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website (www.idorsia.ca); or by calling 1-888-646-1764.

Date of Authorization: 2025-12-23

JERAYGO™ is a trademark of Idorsia Pharmaceuticals Ltd.

Patient Card

PATIENT CARD

PrJERAYGO

aprocitentan tablets

For the treatment of resistant high blood pressure

(hypertension)

This card contains important safety information you need to know when taking JERAYGO.

Show this card to any healthcare professional involved in your medical care.

Liver problems: Like other medicines of the same class, JERAYGO might cause liver problems. Your healthcare professional should do blood tests to check that your liver is working properly before starting treatment with JERAYGO and may also check during your treatment. Tell your healthcare professional right away if you develop symptoms of liver problems including:

  • nausea (feeling sick) or vomiting
  • fever
  • pain in the upper right area of your abdomen (belly)
  • jaundice (yellowing of your skin or the whites of your eyes)
  • dark-coloured urine
  • itching of your skin
  • unusual tiredness or exhaustion
  • loss of appetite

Name of prescribing healthcare professional:

Phone number of prescribing healthcare professional:

Pregnancy:

  • If you take JERAYGO during pregnancy, it may harm your unborn baby. Your healthcare professional will discuss the risks with you.

  • Avoid becoming pregnant while you are taking

    JERAYGO. If you are able to get pregnant, you should use an effective birth control (contraception) method while you are taking JERAYGO and for one month after you stop treatment. Talk to your healthcare professional about the best birth control methods to use while you are taking JERAYGO.

  • Your healthcare professional may recommend that you take a pregnancy test before you start taking JERAYGO, every month while you are taking JERAYGO, and once in the month after you stop taking JERAYGO.

  • If you discover that you are pregnant, stop taking

    JERAYGO and tell your healthcare professional right away.

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02563983

Approved according to the text: December 23, 2025

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Jeraygo

Rx or OTC
Prescription (Rx)?
DIN 02563983, 02563991
Schedule(s) PRESCRIPTION
Active ingredient(s) Aprocitentan
Dosage form(s) Tablet
Route(s) of administration Oral
Drug class (WHO ATC)
  1. C Cardiovascular system drugs
    1. C02 Antihypertensives
      1. C02K Other antihypertensives
        1. C02KN01 Aprocitentan
Company IDORSIA PHARMACEUTICALS LTD
Current status Approved
Strengths and forms
DIN Strength Dosage form(s) Current status
02563983 12.5 MG Tablet Approved December 24, 2025
02563991 25 MG Tablet Approved December 23, 2025

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.