Kamrab: Uses, Side Effects and Dosage

What is KAMRAB used for?

• KamRAB is used to treat rabies infection. It is a single dose treatment used along with a full course of rabies vaccine

How does KAMRAB work?

KAMRAB contains antibodies that inactivate the rabies virus. It is administered as soon as possible after a person is bitten by an animal suspected of being infected with rabies and is injected directly into and around the wound as a single dose.

Any person who might have been exposed to rabies and has never been vaccinated against rabies should receive KAMRAB as well as a series of rabies vaccinations. KAMRAB provides immediate protection against the rabies virus until the person to develop antibodies of his/ her own against the rabies virus.

What are the ingredients in KAMRAB?

Medicinal ingredients: Anti-rabies immunoglobulin (human antibodies to rabies)

Non-medicinal ingredients: glycine, sodium hydroxide and water for injection

KAMRAB comes in the following dosage forms:

Single-use vials containing 2 mL or 10 mL of ready-to-use solution with a potency of 150 IU/mL.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take KAMRAB. Talk about any health conditions or problems you may have, including if you:

• Have any bleeding disorders or take medication for bleeding disorders
• Have an inflammatory condition
• Are receiving high doses of other immunoglobulins.
• Have previously received vaccinations for rabies
• Have recently (within the last 4 months) received live attenuated virus vaccine(s)
• Have previously had allergic reactions after being injected with other immunoglobulins
• Have any immune deficiencies which cause you to be deficient in certain antibodies

• Are pregnant or breast feeding

Other warnings you should know about:

KAMRAB is made from human plasma; therefore, the potential exists that KAMRAB administration may transmit infectious disease such as viruses, both known and unknown, and other diseases such as the Creutzfeldt-Jakob disease (CJD) agent. The risk of getting an infectious disease from KAMRAB administration is very small and is minimized by screening human plasma donors for prior exposure to certain viruses, testing donors for certain viral infections and by designated viral inactivation and removal certain viruses during the manufacturing of KAMRAB; however, there is the possibility that KAMRAB administration could transmit infectious diseases.

KAMRAB administration may interfere with other vaccines. It is important to avoid immunization with measles vaccines within 4 months after KAMRAB administration and avoid immunization with other live vaccines for 3 months after KAMRAB administration.

KAMRAB should not be mixed with the rabies vaccine or injected in the same syringe with the rabies vaccine.

KAMRAB should not be administered into the same injection site on the body where rabies vaccine was injected.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with KAMRAB:

• Administration of other vaccines

How to take KAMRAB:

KAMRAB should be administered by a healthcare professional provider only.

KAMRAB is administered following suspected exposure to a rabid animal, at the time of the first rabies vaccine dose.

If the bite wound is visible, KAMRAB should be injected into and around the bite wound, and any remaining product should be injected intramuscularly in the arm or the thigh.

If the bite would is not visible, or if injection at the bite wound is difficult, KAMRAB should be injected intramuscularly on a part of the body that is far away from the site of any rabies vaccinations.

Usual dose:

The recommended dose of KAMRAB is 20 IU/kg body weight.

Overdose:

Overdose of KamRAB is unlikely. If it does happen, your doctor will treat any symptoms that follow.

What are possible side effects from using KAMRAB?

These are not all the possible side effects you may have when taking KAMRAB. If you experience any side effects not listed here, tell your healthcare professional.

The most frequent side effects occurring with KAMRAB in adults included pain at the site of injection, headache, muscle pain, and upper respiratory tract infection. Less common side effects included joint pain, dizziness, fatigue, abdominal pain, blood in the urine, nausea, feeling faint, bruising, and sunburn.

The most frequent side effects occurring with KAMRAB in children included pain at the site of injection, headache, fever, pain in extremities, bruising, fatigue and vomiting. Less common side effects included injection site redness, injection site swelling, muscle pain, oral pain, wound complication and insomnia.

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting Side Effects

Storage:

Store KAMRAB at 2-8 °C (36-46 °F). Do not freeze.

Keep out of reach and sight of children.

If you want more information about KAMRAB:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html; the manufacturer’s website www.valneva.ca, or by calling 1-855-356-0831.

Last Revised: January 9, 2025