Lynkuet: Uses, Side Effects and Dosage

What LYNKUET is used for:

LYNKUET is used to treat moderate to severe vasomotor symptoms:

• associated with menopause
• caused by a breast cancer related treatment called adjuvant endocrine therapy (AET). AET is an anti-hormonal treatment used to prevent cancer from coming back after anti-cancer treatment.

Vasomotor symptoms are also called hot flashes or night sweats.

How LYNKUET works:

KNDy neurons in the brain help regulate body temperature. During menopause, or use of adjuvant endocrine therapy, estrogen levels decline. KNDy neurons are more active than usual which can cause hot flashes and night sweats. LYNKUET helps to reduce symptoms of hot flashes and night sweats by lowering the activity of KNDy neurons.

The ingredients in LYNKUET are:

Medicinal ingredients: elinzanetant

Non-medicinal ingredients: all-rac-α-Tocopherol, caprylocaproyl macrogolglycerides, ferric oxide red, ferric oxide yellow, gelatin, glycerol monocaprylocaprate, glycerol mono-oleate, pharmaceutical grade printing ink, polysorbate 80, sorbitol special-glycerin and titanium dioxide

LYNKUET comes in the following dosage forms:

Capsule, 60 mg

LYNKUET is available in cartons containing blister packs. Each blister contains 12 capsules with two capsules of LYNKUET per cavity.

Do not use LYNKUET if:

• you are allergic to elinzanetant or any of the other ingredients in this medicine.
• you are taking certain medicines that are strong CYP3A4 inhibitors.
• you are pregnant or think you may be pregnant.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take LYNKUET. Talk about any health conditions or problems you may have, including if you:

• have kidney problems.
• have liver problems.
• have a history of seizures or have risk factors for seizures.
• are 65 years of age or older.

Other warnings you should know about:

• Pregnancy:

  • Do not take LYNKUET if you are pregnant or if you think you might be pregnant. It may harm your unborn baby.
  • If you get pregnant while taking LYNKUET, stop taking it and talk to your healthcare professional right away.
  • Use effective non-hormonal birth control during treatment with LYNKUET. Ask your healthcare professional about birth control options available to you.

• Breastfeeding:

  • Do not take LYNKUET if you are breastfeeding. It is not known if LYNKUET passes through your breast milk.
  • Talk to your healthcare professional about the best way to feed your baby during treatment with LYNKUET.

• Driving and using machines: If you feel tired, dizzy or sleepy when taking LYNKUET, avoid driving or using machines.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with LYNKUET:

• Medicines to treat fungal or bacterial infections such as itraconazole, erythromycin, clarithromycin.
• Medicines to treat HIV infections such as ritonavir.
• Medicines to prevent organ rejection after transplantation such as cyclosporine, tacrolimus.
• Medicines to treat long-term pain such as fentanyl.
• Grapefruit or grapefruit juice. This is because it may increase the amount of LYNKUET in your body, which may increase the risk for side effects.

How to take LYNKUET:

• Always take LYNKUET exactly as your healthcare professional has told you. Check with your healthcare professional if you are not sure.
• Take LYNKUET about the same time each day at bedtime.
• Swallow the capsules whole with a glass of water. Do not cut, chew or crush the capsule.

• Take LYNKUET with or without food.

Usual dose:

• The usual dose is 120 mg (two 60 mg capsules) once a day.
• Your healthcare professional may change your dose if you are taking other medicines.
• Do not stop taking LYNKUET unless your healthcare professional tells you to do so. If you want to stop taking LYNKUET before finishing the prescribed course of treatment, you should talk to your healthcare professional first.

Overdose:

Missed Dose:

• If you missed a dose at bedtime, take the next dose as scheduled on the following day.
• Do not take more than two capsules on the same day to make up for a forgotten dose.

Possible side effects from using LYNKUET:

These are not all the possible side effects you may have when taking LYNKUET. If you experience any side effects not listed here, tell your healthcare professional.

Side effects of LYNKUET may include:

• feeling tired, weak or lacking energy
• dizziness
• feeling drowsy or sleepy
• diarrhea
• muscle spasms
• sensitivity to sunlight
• headache
• feeling pain or discomfort in the stomach or belly area
• acid reflux
• rash
• depression
• depressed mood
• hair loss

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting Side Effects

Storage:

• Store at 15°C to 25°C. Do not freeze.
• LYNKUET should be kept in the original packaging.
• Keep out of reach and sight of children.
• Do not use this medicine after the expiry date stated on the product labels. The expiry date refers to the last day of that month.

If you want more information about LYNKUET:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website http://www.bayer.ca, or by calling Bayer Medical Information at 1-800-265-7382 or emailing canada.medinfo@bayer.com.

Bayer Inc.

2920 Matheson Blvd East

Mississauga, Ontario

L4W 5R6

Canada

Date of Authorization: 2026-08-12

© 2026, Bayer Inc.

^® TM see www.bayer.ca/tm-mc