Patient Medication Information: uses, side effects, how to take - Mar-Metoclopramide
What the medication is used for:
MAR-METOCLOPRAMIDE is a drug used to treat symptoms of slowed stomach emptying seen in people with gastritis, and in those recovering from certain types of gastric tests or surgery.
MAR-METOCLOPRAMIDE, when used before surgery, can help reduce vomiting after surgical procedures.
What it does:
MAR-METOCLOPRAMIDE is a drug used to help speed the movement of food through the stomach and intestines, by stimulating the muscles of the gastrointestinal tract.
When it should not be used:
Do not take MAR-METOCLOPRAMIDE if you:
- are allergic (hypersensitive) to metoclopramide or any of the other ingredients listed in “What the non-medicinal ingredients are.”
- are experiencing bleeding (hemorrhage), a blockage (obstruction), or a tear (perforation) in your stomach or intestines
Metoclopramide should not be used in children less than 1 year of age.
What the medicinal ingredient is:
The active substance of MAR-METOCLOPRAMIDE is metoclopramide hydrochloride.
What the non-medicinal ingredients are:
Tablets: Cellulose, Microcrystalline (Avicel PH 101), Colloidal Anhydrous silica (Aerosil 200), Dried Maize starch, Stearic acid 50, Hydroxy Propyl Methyl Cellulose (HPMC E5), Polyethylene Glycol (PEG 6000), Pregelatinized starch (Starch 1500), Purified Talc, Titanium Dioxide
What dosage forms it comes in:
MAR-METOCLOPRAMIDE is available in 5 mg and 10 mg tablets.
Before you use MAR-METOCLOPRAMIDE be sure to tell your doctor or pharmacist if you:
- have a history of bleeding (hemorrhage), a blockage (obstruction), or a tear (perforation) in your stomach or intestines
- have a history of seizures (e.g., epilepsy)
are pregnant. MAR-METOCLOPRAMIDE should not be taken in pregnancy unless your doctor believes the benefit outweighs the risk to the fetus
- are breastfeeding. Metoclopramide can pass into the breast milk and harm your baby. Talk to your doctor about the best way to feed your baby if you take metoclopramide
- have ever been diagnosed with breast cancer
- have kidney problems
- have an adrenal gland tumour called pheochromocytoma
Contact your doctor immediately if the following occur while taking metoclopramide:
- You develop symptoms of tardive dyskinesia or dystonia with symptoms such as involuntary movement of lips, eyes, tongue, face, head and limbs.
ABOUT THIS MEDICATION
WARNINGS AND PRECAUTIONS
- A condition called tardive dyskinesia (see description below) has occurred with long-term (over 12 weeks) use of metoclopramide and even after long-term treatment has been stopped. The chance of this occurring increases with duration of treatment, total cumulative dose and in the elderly, particularly elderly women.
Children:
- metoclopramide must not be used in children under 1 year of age.
- metoclopramide should not be used in children over 1 year of age unless the doctor believes the benefit outweighs the risk.
- extrapyramidal symptoms (e.g. shaking, tremor, stiffness and involuntary movement) may occur in children. Children's dosage should not exceed 0.5 mg/kg/day.
IMPORTANT: PLEASE READ
- You develop Parkinson’s symptoms such as tremor, restlessness, muscle rigidity, facial spasms, involuntary movements, and difficulty completing daily tasks.
- You develop symptoms of neuroleptic malignant syndrome with symptoms such as high temperature, muscle rigidity, irregular or fast heartbeat.
- You feel depressed or have thoughts about hurting or killing yourself.
Overdose:
If you think you have taken too much MAR-METOCLOPRAMIDE, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.
Missed Dose: Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Some medications may block the effects of MAR-METOCLOPRAMIDE, such as anticholinergic drugs.
MAR-METOCLOPRAMIDE may intensify the effect of alcohol and drugs absorbed from the intestines, such as neuroleptics.
Interactions may occur with monoamine oxidase inhibitors (e.g., some drugs used to treat depression).
Some drugs may increase the risk of drowsiness with MAR-METOCLOPRAMIDE, such as sedatives, hypnotics, narcotics, and anxiolytics.
MAR-METOCLOPRAMIDE may decrease the absorption of drugs from the stomach (e.g., digoxin) whereas absorption from the small bowel may be accelerated (e.g. acetaminophen, tetracyclines, levodopa, alcohol).
Usual dose:
Note: The total adult and pediatric daily dosage must not exceed 0.5 mg/kg/body weight.
For Delayed Gastric Emptying
Adults:
Tablets: 5 to 10 mg 3 or 4 times a day before meals, depending upon response, body weight, and kidney function.
Children (5 to 14 years):
Tablets: 2.5 to 5 mg 3 times a day before meals, depending upon response and body weight.
Depending how well you respond to treatment and safety considerations, your dosage of MAR-METOCLOPRAMIDE may be increased or decreased by your doctor, as appropriate.
Note: MAR-METOCLOPRAMIDE is only
available as Tablets.
Common side effects
The most common side effects are drowsiness and fatigue.
Other possible common side effects include insomnia, headache, dizziness and bowel disturbances.
If any of these affects you severely, tell your doctor.
If you notice any other side effects not mentioned in this leaflet, please inform your doctor or pharmacist.
| SERIOUS SIDE EFFECTS AND WHAT TO DO ABOUT THEM | ||||||
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | ||||
| Only if severe | In all cases | |||||
| R A R E | Muscular twitching | √ | ||||
| Restlessness | √ | |||||
| Facial Spasms or movements | √ | |||||
| Unusual eye movements | √ | |||||
| Involuntary or unusual movements | √ | |||||
| Muscle rigidity | √ | |||||
| Tremors | √ | |||||
| High temperature, fast or irregular heartbeat | √ | |||||
| Feeling depressed or thoughts about hurting or killing yourself | √ | |||||
| Hypersensitivity (allergic) reaction with symptoms such as rash, hives, breathing difficulty, swelling of the mouth, throat and extremities | √ | |||||
SIDE EFFECTS AND WHAT TO DO ABOUT THEM
INTERACTIONS WITH THIS MEDICATION
PROPER USE OF THIS MEDICATION
IMPORTANT: PLEASE READ
This is not a complete list of side effects. For any unexpected effects while taking MAR-METOCLOPRAMIDE, contact your doctor or pharmacist.
Tablets: Store between 15°C and 30°C. Protect from light.
Keep out of the reach and sight of children.
Note: MAR-METOCLOPRAMIDE is only available as Tablets.
If you want more information about MAR-METOCLOPRAMIDE:
- Talk with your healthcare professional
Find the full product monograph that is prepared for healthcare
professionals and includes this Patient Medication Information by visiting the Health Canada website
(https://health-products.canada.ca/dpd-bdpp/index-eng.jsp);
the manufacturer’s website www.marcanpharma.com, or by calling 1-855-627-2261.
2 Gurdwara Road, Suite #112, Ottawa, ON, K2E 1A2.
Last Revised: July 6, 2021
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
- Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html ) for information on how to report online, by mail or by fax; or
- Calling toll-free at 1-866-234-2345.
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.
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