Patient Medication Information: uses, side effects, how to take - Mint-Tizanidine
What MINT-TIZANIDINE is used for:
MINT-TIZANIDINE is used in adults to relieve muscle stiffness and cramping (spasms) caused by certain medical conditions. This includes conditions such as multiple sclerosis or injuries to the spine.
How MINT-TIZANIDINE works:
MINT-TIZANIDINE belongs to a group of medicines called antispastic agents. It decreases nerve activity in the spinal cord that causes involuntary muscle contractions. This reduces muscle stiffness and spasms.
The ingredients in MINT-TIZANIDINE are:
Medicinal ingredient: Tizanidine hydrochloride.
Non-medicinal ingredients: Anhydrous lactose, colloidal silicon dioxide, microcrystalline cellulose and stearic acid.
MINT-TIZANIDINE comes in the following dosage form:
Tablets: 4 mg
Do not use MINT-TIZANIDINE if:
- you are allergic to tizanidine hydrochloride or to any of the other ingredients in MINT-TIZANIDINE.
- you are currently taking medicines that can cause high levels of MINT-TIZANIDINE in your blood. This includes fluvoxamine (used to treat mental health problems) and ciprofloxacin (used to treat bacterial infections). Ask your healthcare professional if you are not sure.
- muscle tension allows you to keep an upright posture, to balance during movement, or helps you carry out your daily activities.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take MINT-TIZANIDINE. Talk about any health conditions or problems you may have, including if you:
- are currently taking other medicines.
are pregnant, think you might be pregnant or planning to become pregnant. It is not known if MINT-TIZANIDINE can harm an unborn baby. Your healthcare professional will only give you MINT-TIZANIDINE if the potential benefits outweigh the potential risks to you and your baby.
- are breast-feeding or plan to breastfeed. It is not known if MINT-TIZANIDINE can pass into breast milk and harm a breastfed baby. However, due to its chemical profile, it is likely to pass into breastmilk.
- have liver problems.
- have kidney problems.
- have a history of illicit or prescription drug abuse.
- have or have had low blood pressure when going from a sitting or lying position to standing, have fluctuating blood pressure, or are taking medicines to treat high blood pressure.
- have or have had a psychotic disorder (e.g., psychosis, schizophrenia).
- are elderly. You have a higher risk of experiencing side effects while taking MINT-TIZANIDINE.
are lactose intolerant or have one of the following rare hereditary diseases:
- Galactose intolerance
- Lapp lactase deficiency
- Glucose-galactose malabsorption
Because MINT-TIZANIDINE contains lactose.
Other warnings you should know about:
Dependence: MINT-TIZANIDINE may cause physical dependence, especially when taken in high doses or over extended periods. This means you may experience withdrawal symptoms if you suddenly stop taking the medication.
Abuse and misuse: Cases of abuse and misuse have also been reported with tizanidine tablets, mainly when taken with other illicit or prescription drugs. Your healthcare professional will monitor you for signs of misuse and abuse during your treatment with MINT-TIZANIDINE.
It is important that you talk to your healthcare professional if you have questions or concerns about dependence, or about misuse.
Stopping treatment: Do not suddenly stop taking MINT-TIZANIDINE without talking to your healthcare professional first. If you do, it could cause withdrawal symptoms such as high blood pressure, fast heart rate, muscle pain/cramping, shaking (tremor), seizures, and/or anxiety. If your healthcare professional decides that you should stop taking MINT-TIZANIDINE, your dose will be gradually reduced before you stop taking the medicine completely. Your healthcare professional will closely monitor your health during this time.
Driving and using machines: MINT-TIZANIDINE may make you have blurry vision or feel sedated. Sedation means you may feel drowsy, relaxed and have reduced awareness. Taking MINT-TIZANIDINE with certain substances (e.g., alcohol) or medicines (e.g., other muscle relaxants, benzodiazepines) can make it worse. If sedation interferes with your daily activities, tell your healthcare professional. You should not drive or use tools or machinery until you know how you respond to MINT-TIZANIDINE.
Hypotension (low blood pressure): MINT-TIZANIDINE may cause a decrease in your blood pressure. This may cause dizziness, lightheadedness, or fainting when a person rises suddenly from a sitting or lying position. Rising slowly may decrease the risk of these problems
Liver damage: MINT-TIZANIDINE can cause liver injury. Liver function is usually monitored during treatment with MINT-TIZANIDINE. If you experience nausea, fatigue, or loss of appetite, tell your healthcare professional right away.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
Serious drug interactions:
Serious drug interactions with MINT-TIZANIDINE include:
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The following may also interact with MINT-TIZANIDINE:
alcohol and medicines that slow down the activity of the central nervous system (i.e., CNS depressants) such as:
- medicines causing drowsiness or decreased alertness such as antihistamines, sedatives, tranquilizers, and sleeping medications.
- opioids, used to relieve pain.
- certain medicines used to treat depression (i.e., tricyclic antidepressants).
- benzodiazepines, used to treat anxiety.
- other muscle relaxants, such as baclofen.
- birth control pills.
- medicines used to treat high blood pressure.
- medicines known to affect the way your heart beats or used to treat an abnormal heartbeat (e.g., amiodarone, mexiletine, propafenone).
- cimetidine, used to reduce stomach acid.
- certain medicines used to treat bacterial infections known as fluoroquinolones (e.g., norfloxacin, moxifloxacin).
- ticlopidine, used to prevent blood clotting.
How to take MINT-TIZANIDINE:
- Take MINT-TIZANIDINE exactly as your healthcare professional has told you.
Food can affect the absorption of MINT-TIZANIDINE in your body. It is important to take it in the same way all the time. If you normally take MINT-TIZANIDINE with a meal, you should take it with food each time. If you normally take MINT-TIZANIDINE on an empty stomach, then you should always take it either 1 hour before or 2 hours after a meal.
- Do not suddenly stop taking MINT-TIZANIDINE without talking to your healthcare professional first. Stopping your treatment must be a gradual process that you discuss with your healthcare professional.
Usual dose:
Usual adult dose: 2 mg to 8 mg, taken up to 3 times daily.
During the first weeks of treatment, your healthcare professional may adjust your dose to find the one that works best for you.
Maximum dose: 36 mg per day, with a maximum of 12 mg per single dose.
Overdose:
Symptoms of an overdose with MINT-TIZANIDINE include:
- sleepiness,
- very long or deep sleeplike state from which a person can be awakened only briefly by vigorous stimulation (stupor) or cannot be at all (coma),
- low heart rate
- low blood pressure,
- difficulty breathing.
| If you think you, or a person you are caring for, have taken too much MINT-TIZANIDINE, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms. |
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Missed dose:
If you missed a dose of this medication, you do not need to make up the missed dose. Skip the missed dose and continue with your next scheduled dose. Do not take a double dose.
Possible side effects from using MINT-TIZANIDINE:
These are not all the possible side effects you may have when taking MINT-TIZANIDINE. If you experience any side effects not listed here, tell your healthcare professional.
Side effects with MINT-TIZANIDINE may include:
- fever
- dry mouth
- drowsiness
- weakness
- fatigue
- constipation
- vomiting
- bladder infection
- slurred speech
- feeling nervous
- blurry vision
- frequent urination
- uncontrolled, involuntary muscle movements
- dizziness
Serious side effects and what to do about them
| Frequency/Side Effect/Symptom | Talk to your healthcare professional | Stop taking this drug and get immediate medical help | |
|---|---|---|---|
| Frequency/Side Effect/Symptom | Talk to your healthcare professional | Stop taking this drug and get immediate medical help | |
| Only if severe | In all cases | ||
| Only if severe | In all cases | ||
| Very common | |||
| Excessive sedation (extreme sleepiness or relaxation) | ✓ | ||
| Uncommon | |||
| Heart rhythm problems: dizziness, palpitations (sensation of rapid, pounding, or irregular heartbeat), fainting, or seizures | ✓ | ||
| Hypotension (low blood pressure): dizziness, fainting, light-headedness, blurred vision, nausea, vomiting, fatigue (may occur when you go from lying or sitting to standing up) | ✓ | ||
| Very rare | |||
| Allergic reaction: difficulty swallowing or breathing, wheezing, feeling sick to your stomach and throwing up, hives or rash, swelling of the face, lips, tongue or throat | ✓ | ||
| Liver problems: jaundice (yellowing of the skin or whites of eyes), unusual dark urine, light-colored stool, loss of appetite, nausea, vomiting, abdomen pain or swelling, unusual tiredness, mental disorientation or confusion, sleepiness, coma | ✓ | ||
| Mental changes: hallucinations (seeing or hearing things that are not there) or delusions (false, fixed beliefs despite facts showing that they are not true) | ✓ | ||
| Rhabdomyolysis: (breakdown of muscle fibers): sore or tender muscles, red-brown urine (dark tea-coloured), fever | ✓ | ||
| Unknown | |||
| Sudden discontinuation of medicine: high heart rate, muscle cramps or stiffness, seizures, shaking (tremors), anxiety, | ✓ | ||
| weakness, fatigue, tiredness, dry mouth, dizziness | |||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting side effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
MINT-TIZANIDINE should be stored 15 - 30°C and away from heat and direct light. Keep out of reach and sight of children.
If you want more information about MINT-TIZANIDINE:
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes the Patient Medication Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); or the manufacturer’s website www.mintpharma.com.
Date of Authorization: 2026-07-29