Patient Medication Information: uses, side effects, how to take - Mnexspike
What mNEXSPIKE is used for:
mNEXSPIKE is a vaccine to protect you against coronavirus disease 19 (COVID-19) caused by the SARS-CoV-2 virus. mNEXSPIKE is for adults 18 years of age and older.
How mNEXSPIKE works:
mNEXSPIKE works by causing the body to produce its own protection (through your immune system) against the SARS-CoV-2 virus that causes the COVID-19 infection. mNEXSPIKE uses a molecule called messenger ribonucleic acid (mRNA, the genetic code for a piece of the virus) to deliver the set of instructions that cells in your body can use to make antibodies to help fight the virus that causes COVID-19. The vaccine is given by injection with a needle in the upper arm.
mNEXSPIKE does not contain SARS-CoV-2, the virus that causes COVID-19. You cannot get COVID-19 from this vaccine.
As with all vaccines, mNEXSPIKE may not fully protect all people who receive the vaccine.
Even after you have had the vaccine, continue to follow the recommendations of local public health officials to prevent the spread of COVID-19.
The ingredients in mNEXSPIKE are:
Medicinal ingredient(s): One 0.2 mL dose of mNEXSPIKE contains 10 micrograms of mRNA encoding SARS-COV-2 spike protein NTD-RBD subdomains.
Non-medicinal ingredients:
- cholesterol
- DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine)
- SM-102 (heptadecan-9-yl 8-((2-hydroxyethyl) (6-oxo-6-(undecyloxy) hexyl)amino) octanoate)
- PEG2000-DMG (1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000)
- sucrose
- trometamol
- trometamol hydrochloride
- water for injection
mNEXSPIKE does not contain preservatives.
mNEXSPIKE comes in the following dosage form(s):
mNEXSPIKE is available as a dispersion for intramuscular injection. mNEXSPIKE comes in a single-dose (0.2 mL), pre-filled syringe.
Do not receive mNEXSPIKE if:
- you are allergic to the active substance or any of the other ingredients of this vaccine (see What are the ingredients in mNEXSPIKE?)
- you have had an allergic reaction to a previous dose of Moderna COVID-19 vaccine
To help avoid side effects and ensure proper use, talk to your healthcare professional before you receive mNEXSPIKE. Talk about any health conditions or problems you may have, including if you:
- have any allergies
- had a severe allergic reaction after receiving a previous dose of any COVID-19 vaccine
- have had myocarditis (inflammation of the heart muscle) or pericarditis (inflammation of the lining outside the heart)
- have a fever
- have a bleeding disorder or are on a blood thinner
- are immunocompromised or are on a medicine that affects your immune system
are pregnant or plan to become pregnant
- are breastfeeding
- have received any other COVID-19 vaccine
- have ever fainted in association with an injection
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with mNEXSPIKE:
There is limited information on the use of mNEXSPIKE with other vaccines. Tell your healthcare professional if you have recently received any other vaccine.
How is mNEXSPIKE given:
Your doctor, pharmacist or nurse will inject the vaccine into a muscle (intramuscular injection) in your upper arm.
- During and after each injection of the vaccine, your doctor, pharmacist or nurse will watch over you for around 15 minutes to monitor for signs of an allergic reaction.
Usual dose:
mNEXSPIKE is given as a single dose of 0.2 mL as an injection.
Overdose:
| If you think you, or a person you are caring for, have received too much mNEXSPIKE, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms. |
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Possible side effects from using mNEXSPIKE:
Like all vaccines, mNEXSPIKE can cause side effects, although not everyone gets them.
The following side effects may occur after receiving mNEXSPIKE. Most of these side effects are mild and do not last long. These are not all the possible side effects you may have when receiving mNEXSPIKE.
Very common (these may occur with more than 1 in 10 doses of the vaccine):
- chills
- enlarged lymph nodes
- headache
- muscle ache and stiffness
- nausea and/or vomiting
- pain at the injection site
- tiredness, sleepiness
Common (these may occur with up to 1 in 10 doses of the vaccine):
- fever
- swelling or redness at the injection site
Severe allergic reactions have occurred in some people who have received mNEXSPIKE and other COVID-19 vaccines. There is a very small chance that mNEXSPIKE could cause a severe allergic reaction. A severe allergic reaction would usually occur within a few minutes to 1 hour after getting a dose of mNEXSPIKE. For this reason, your healthcare provider may ask you to stay for a short time at the place where you received the vaccine. Signs of a severe allergic reaction can include:
- trouble breathing
- swelling of your face and throat
- a fast heartbeat
- a rash all over your body
- dizziness and weakness
If you experience a severe allergic reaction, call 9-1-1, or go to the nearest hospital.
Myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the lining outside the heart) have occurred in some people who have received COVID-19 vaccines, most commonly in adolescent and young adult males. In most of these individuals, symptoms began within a few days following vaccination. The chance of having this occur is very low. You should seek medical attention right away if you have any of the following symptoms after receiving the vaccine, particularly during the 2 weeks after receiving a dose of the vaccine:
- chest pain
- shortness of breath
- feelings of having a fast-beating, fluttering, or pounding heart
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting suspected side effects for vaccines For the general public: Should you experience a side effect following immunization, please report it to your healthcare professional. Should you require information related to the management of the side effect, please contact your healthcare professional. The Public Health Agency of Canada (PHAC), Health Canada (HC), and Moderna Biopharma Canada Corporation cannot provide medical advice. For healthcare professionals: If a patient experiences a side effect following immunization, please complete the Adverse Events Following Immunization (AEFI) Form appropriate for your province/territory (Reporting Adverse Events Following Immunization (AEFI) in Canada) and send it to your local Health Unit. |
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Storage:
Your doctor or pharmacist is responsible for storing, supplying and administering mNEXSPIKE, as well as disposing of any unused product correctly.
Keep out of reach and sight of children.
If you want more information about mNEXSPIKE:
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes the Patient Medication Information by visiting the Health Canada Drug Product Database website (Drug Product Database: Access the database); the manufacturer’s website https://www.modernatx.com/en-ca/products, or by calling 1-866-MODERNA (1-866-663-3762).
Date of Authorization: 2026-07-06
©2026 ModernaTX, Inc. All rights reserved. mNEXSPIKE is a trademark of ModernaTX, Inc.