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Penicillin G Sodium for Injection: Uses, Side Effects and Dosage

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Prescription (Rx)
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10000000 UNIT, 1000000 UNIT, 5000000 UNIT
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Patient Medication Information: uses, side effects, how to take - Penicillin G Sodium for Injection

What is Penicillin G Sodium for Injection used for?

  • Penicillin G Sodium for Injection is used to treat infections that are caused by certain types of bacteria.
  • Antibacterial drugs like Penicillin G Sodium for Injection treat only bacterial infections. They do not treat viral infections.

How does Penicillin G Sodium for Injection work?

Penicillin G Sodium for Injection is an antibiotic that belongs to the penicillin class. It works by killing or stopping the growth of the bacteria that caused your infection.

What are the ingredients in Penicillin G Sodium for Injection?

Medicinal Ingredient: penicillin G sodium

Penicillin G Sodium for Injection comes in the following dosage forms:

Penicillin G Sodium for Injection is supplied as a dry powder in vials containing: 1 million, 5 million, or 10 million penicillin G units (as penicillin G sodium).

Do not use Penicillin G Sodium for Injection if:

  • you are allergic to penicillin G sodium or other penicillin products.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Penicillin G Sodium for Injection. Talk about any health conditions or problems you may have, including if you:

  • have had previous allergic reactions to other penicillins, cephalosporins, and other allergens.
  • have asthma.
  • have kidney disease.
  • have heart disease or vascular disease (issues with your veins or arteries).
  • are pregnant or planning to become pregnant.

  • are breastfeeding or planning to breastfeed.

Other warnings you should know about:

  • Your doctor may order certain tests or exams while you are taking Penicillin G Sodium for Injection.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with Penicillin G Sodium for Injection:

  • Antibiotics such as chloramphenicol, erythromycins, sulfonamides, and tetracyclines
  • Probenecid (to treat gout)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, phenylbutazone, and indomethacin
  • Diuretics such as thiazide diuretics, furosemide, and ethacrynic acid

How to take Penicillin G Sodium for Injection:

  • Although you may feel better early in treatment, Penicillin G Sodium for Injection should be used exactly as directed.
  • Misuse or overuse of Penicillin G Sodium for Injection could lead to the growth of bacteria that will not be killed by Penicillin G Sodium for Injection (resistance). This means that Penicillin G Sodium for Injection may not work for you in the future.
  • Do not share your medicine.
  • Your healthcare professional will prepare Penicillin G Sodium for Injection before administering.

Adult dose:

  • Your healthcare professional will decide your dose based on your infection.

Infant and children dose:

  • Your healthcare professional will decide your child’s dose based on their weight and infection.

Overdose:

If you think you, or a person you are caring for, have taken too much Penicillin G Sodium for Injection, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X

(1-844-764-7669) immediately, even if there are no signs or symptoms.

What are possible side effects from using Penicillin G Sodium for Injection?

These are not all the possible side effects you may feel when taking Penicillin G Sodium for Injection. If you experience any side effects not listed here, contact your healthcare professional.

Serious side effects and what to do about them

Symptom / effectTalk to your healthcare professionalStop taking drug and get immediate medical help
Only if severeIn all cases
Jarisch–Herxheimer Reaction (Syphilis-Related Reaction): fever, headache, shaking chills, sweating, temporary worsening of sores, seizures, stroke, muscle pain, rapid heart rate, hyperventilation, flushing, and low blood pressureX
Allergic Reaction: chills, fever, hives joint pain, rash, swelling, nausea, itching, muscle spasms, low blood pressure, vascular failure, difficulty breathing, discomfort, and abdominal painX
Neuropathy (Nervous System Damage): weakness, numbness, pain, overactive reflexes, muscle twitches, seizures, and comaX
Congestive Heart Failure: chest discomfort with unpleasant awareness of your heartbeat, faintness, shortness of breath, and weaknessX
Nephropathy (Kidney Disease): back and abdominal pain, change in the colour of urine (pale or dark), decrease in amount of urine produced, pain or discomfort when urinating, swelling of the legs and ankles, and blood in the urineX
Pseudomembranous Colitis (Inflammation of the Colon): nausea, vomiting, inflammation of mouth or lips, black or hairy tongue, and gastrointestinal irritationX
Electrolyte Disturbances: weakness, drowsiness, muscle pain or cramps, and irregular heartbeatX
Phlebitis (Swelling of a Vein): pain, tenderness, and redness or swellingX
Thrombophlebitis (Blood Clots): swelling and redness along a vein which is extremely tender or painful when touchedX

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to

Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

  • Store dry powder at a controlled room temperature (15 °C to 30 °C).
  • Keep out of reach and sight of children.

If you want more information about Penicillin G Sodium for Injection:

  • Talk to your healthcare professional
  • Find the full Prescribing Information that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); Fresenius Kabi Canada’s website (https://fresenius-kabi.com/ca/en), or by calling 1-877-821-7724.

Fresenius Kabi Canada Ltd.

165 Galaxy Blvd, Suite 100

Toronto, ON M9W 0C8

Last revised: May 7, 2026

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02568209

Revision date stated in the text: May 7, 2026

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Penicillin G Sodium for Injection

Rx or OTC
Prescription (Rx)?
DIN 02568209, 02568217, 02568225
Schedule(s) PRESCRIPTION
Active ingredient(s) Penicillin g (penicillin g sodium)
Dosage form(s) Powder For Solution
Route(s) of administration Intramuscular, Intravenous
Drug class (WHO ATC)
  1. J Antiinfectives for systemic use
    1. J01 Antibacterials for systemic use
      1. J01C Beta-lactam antibacterials, penicillins
        1. J01CE Beta-lactamase sensitive penicillins
          1. J01CE01 Benzylpenicillin
Company FRESENIUS KABI CANADA LTD
Current status Approved
Current status date May 7, 2026
Strengths and forms
DIN Strength Dosage form(s) Current status
02568209 10000000 UNIT Powder For Solution Approved May 7, 2026
02568217 1000000 UNIT Powder For Solution Approved May 7, 2026
02568225 5000000 UNIT Powder For Solution Approved May 7, 2026

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.