Patient Medication Information: uses, side effects, how to take - Persantine
Serious Warnings and Precautions
PERSANTINE may cause sudden death, heart attack, and changes to your heart rhythm. PERSANTINE should only be used in a clinical setting that has the appropriate equipment and under the monitoring of a trained healthcare professional.
What is PERSANTINE used for?
Myocardial perfusion imaging is a test to show how well blood flows through the heart muscle. PERSANTINE is given intravenously to adults as part of the test to increase the blood flow to the heart.
How does PERSANTINE work?
PERSANTINE widens the blood vessels of the heart muscle. This increases the blood flow to the heart
What are the ingredients in PERSANTINE?
Medicinal ingredient: dipyridamole
Non-medicinal ingredients: hydrochloric acid, polyethylene glycol, sterile water for injection and tartaric acid.
PERSANTINE comes in the following dosage forms:
Solution; 5 mg / mL
Do not use PERSANTINE if:
- You are allergic to dipyridamole or any of the other ingredients in PERSANTINE.
You are in shock or circulatory collapse. Symptoms include:
- loss of consciousness
- rapid breathing or severe shortness of breath
- sudden rapid heartbeat
- weak pulse and low blood pressure
- sweating
- pale skin
To help avoid side effects and ensure proper use, talk to your healthcare professional before you are given PERSANTINE. Talk about any health conditions or problems you may have, including if you:
Have or ever had any heart problems, such as:
- a heart attack,
- coronary artery disease,
- angina (chest pain),
- irregular heart beat,
- heart block (this usually causes a slow heart beat),
- heart failure, or
- problems affecting the heart valves.
- Have low blood pressure.
- Had a stroke or something called a transient ischemic attack (temporary stroke symptoms lasting less than 24 hours).
- Have breathing problems such as asthma, shortness of breath or wheezing.
Are pregnant or plan to become pregnant. Your healthcare professional will decide if giving you PERSANTINE outweighs the potential risk to your unborn baby.
- Are breastfeeding or plan to breastfeed. PERSANTINE passes into breast milk.
- Are orally taking drugs containing dipyridamole. Oral dipyridamole may weaken the sensitivity of the test. Your healthcare professional may ask you to stop taking it for 24 hours prior to receiving PERSANTINE.
Other warnings you should know about:
Heart problems: In patients with a history of heart problems, PERSANTINE can cause chest pain, low blood pressure, an irregular or abnormal heartbeat, problems breathing and severe nausea, vomiting or headache. Your healthcare professional will monitor your infusion, the scan and your heart rhythm to check your health.
Driving and using machines: PERSANTIVE may cause dizziness. If you experience dizziness, do not drive or use machinery for 24 hours after receiving PERSANTINE.
Gallstones: Dipyridamole has been found in gallstones. If you are elderly, have an inflamed bile duct (cholangitis), or have taken oral dipyridamole for a number years, you may be more likely to develop gallstones.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with PERSANTINE:
- drug used to treat heart rhythm problems or used as a diagnostic agent called adenosine
- drugs used to treat asthma, and other breathing problems such as theophylline and aminophylline
- drugs used to prevent blood clots such as oral dipyridamole and anticoagulants including warfarin
- drugs used to treat blood clots called thrombolytics
- drug used to reduce pain, fever or inflammation called acetylsalicylic acid
- drugs used to lower blood pressure
- drugs used to treat Alzheimer’s and dementia called cholinesterase inhibitors
- xanthine derivatives which may be present in tea, coffee, soft drinks or chocolate
How PERSANTINE is given:
- Your healthcare professional may ask you to stop drinking tea or coffee for 24 hours before receiving PERSANTINE. Tea and coffee may weaken the sensitivity of the test.
- PERSANTINE will be given to you as in infusion into the vein (intravenous infusion) by a healthcare professional.
- The infusion will take 4 minutes.
- Another injection containing the imaging agent will be given within 5 minutes of the PERSANTINE infusion.
Usual Dose:
Your healthcare professional will determine the dose that is right for you. Your dose will depend of your weight.
Overdose:
Some of the signs of an overdose could be:
- feeling warm or flushed
- sweating
- rapid pulse
- restlessness
- feeling of weakness and dizziness,
- chest pain or difficulty breathing
- drop in blood pressure
- abnormally fast heartbeat
| If you think you, or a person you are caring for, have taken too much PERSANTINE, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms. |
|---|
What are possible side effects from using PERSANTINE?
These are not all the possible side effects you may have when taking PERSANTINE. If you experience any side effects not listed here, tell your healthcare professional.
Side effects may include:
- rash
- hives
- muscle aches and pain
- feeling tired or lacking energy
Serious side effects and what to do about them
| Symptom ⁄ effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| VERY COMMON | |||
| Headache | ✓ | ||
| Dizziness | ✓ | ||
| Angina pectoris: (not enough oxygen to the heart muscle): discomfort in the shoulder, arm, back, throat, jaw or teeth; pain or pressure in the chest | ✓ | ||
| COMMON | |||
| Paraesthesia (pins and needles): sensation of tingling, pain or numbness in hands, fingers and toes | ✓ | ||
| Arrhythmia (abnormal heart rhythms): rapid, slow or irregular heartbeat | ✓ | ||
| Tachycardia (abnormally fast heart beat): dizziness, light headedness, shortness of breath, racing heart | ✓ | ||
| Hypotension (low blood pressure): dizziness, fainting, light-headedness, blurred vision, nausea, vomiting, fatigue (may occur when you go from lying or sitting to standing up) | ✓ | ||
| Hot flush: (feeling intensive warmth with sweating and rapid heartbeats) redness in the face and neck | ✓ | ||
| Nausea | ✓ | ||
| UNCOMMON | |||
| Myocardial infarction (heart attack): pressure or squeezing pain between the shoulder blades, in the chest, jaw, left arm or upper abdomen, shortness of breath, dizziness, fatigue, light- | ✓ | ||
| headedness, clammy skin, sweating, indigestion, anxiety, feeling faint and possible irregular heartbeat | |||
|---|---|---|---|
| Bradycardia (abnormally slow heartbeat) | ✓ | ||
| Bronchospasm: difficulty breathing and coughing, chest tightness, wheezing or whistling sound when breathing | ✓ | ||
| Abdominal pain | ✓ | ||
| RARE | |||
| Anaphylactoid Reaction: difficulty swallowing or breathing, wheezing, drop in blood pressure, feeling sick to your stomach and throwing up, hives or rash, swelling of the face, lips, tongue or throat | ✓ | ||
| Temporary symptoms of stroke | ✓ | ||
| VERY RARE | |||
| Stroke: Sudden numbness or weakness of your arm, leg or face, especially if only on one side of the body; sudden confusion, difficulty speaking or understanding others; sudden difficulty in walking or loss of balance or coordination; suddenly feeling dizzy or sudden severe headache with no known cause. | ✓ | ||
| Seizure (fit): uncontrollable shaking with or without loss of consciousness | ✓ | ||
| Fibrillation (abnormal heart rhythm which is rapid and irregular): chest discomfort with unpleasant awareness of your heartbeat, faintness, shortness of breath, weakness | ✓ | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
Store PERSANTINE at room temperature (15-30°C). Protect from light. Protect from freezing.
If you want more information about PERSANTINE:
- Talk to your healthcare professional.
- Find the full Product Monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html or the manufacturer’s website
| UNKNOWN | |||
|---|---|---|---|
| Fainting: a temporary loss of consciousness due to a sudden drop in blood pressure | ✓ | ||
| Temporary pause in the normal heart rhythm | ✓ | ||
| Atrioventricular Block: light-headedness, fainting, tiredness, shortness of breath, chest pain | ✓ | ||
| Laryngospasm (spasm of the vocal cords): difficulty breathing or speaking | ✓ | ||
| Diarrhea | ✓ | ||
| Vomiting | ✓ | ||
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