Patient Medication Information: uses, side effects, how to take - PMS-Pyrazinamide
What is pms-PYRAZINAMIDE used for?
- pms-PYRAZINAMIDE is used along with other antituberculosis agents to treat all forms of tuberculosis (an infection of the lungs).
- Antibacterial drugs like pms-PYRAZINAMIDE treats only bacterial infections. They do not treat viral infections such as the common cold.
How does pms-PYRAZINAMIDE work?
pms-PYRAZINAMIDE is an antibiotic that works by:
- Stopping the growth of bacteria.
- Killing bacteria
- Reducing the infection
What are the ingredients in pms-PYRAZINAMIDE?
Medicinal ingredients: Pyrazinamide
Pregelatinized Starch, Corn Starch, Microcrystalline Cellulose, Stearic Acid, Colloidal Silicon Dioxide
pms-PYRAZINAMIDE comes in the following dosage forms:
500 mg Tablets
Do not use pms-PYRAZINAMIDE if:
- You are allergic to any of the ingredients in pms-PYRAZINAMIDE.
- You have liver damages.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take pms-PYRAZINAMIDE. Talk about any health conditions or problems you may have, including if you:
- Have a condition called gout;
- Have reduced kidney function or other kidney problems;
- Are hypersensitive to ethionamide, isoniazid, niacin (nicotinic acid) or other related medications;
- Have diabetes;
Are pregnant or are planning to become pregnant;
- Are breastfeeding or planning to breastfeed;
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with pms-PYRAZINAMIDE:
- Allopurinol
- Colchicine
- Probenecid
- Sulfinpyrazone
- Cyclosporine
How to take pms-PYRAZINAMIDE:
- Swallow pms-PYRAZINAMIDE tablets with water.
- You will take pms-PYRAZINAMIDE with other antituberculosis drugs.
- Your doctor will decide how much pms-PYRAZINAMIDE you should take, when you should take it and for how long you should take it.
- Although you may feel better early in treatment, pms-PYRAZINAMIDE should be taken exactly as directed.
- Misuse or overuse of pms-PYRAZINAMIDE could lead to the growth of bacteria that will not be killed by pms-PYRAZINAMIDE (resistance). This means that pms-PYRAZINAMIDE may not work for you in the future.
- Do not share your medicine.
Usual dose
Adult and adolescent dose:
- The dose you are given will be based on your weight. It is usually around 15 to 30 mg per kg of bodyweight once a day or 50 to 70 mg per kg of bodyweight two or three times a week.
- The dose can be different from one person to another.
Pediatric dose:
- The dose you are given will be based on your weight. It is usually around 30 mg per kg of bodyweight or less.
- The dose can be different from one person to another.
Overdose:
What are possible side effects from using pms-PYRAZINAMIDE?
These are not all the possible side effects you may feel when taking pms-PYRAZINAMIDE If you experience any side effects not listed here, contact your healthcare professional.
Side effects may include:
- acne
- painful urination (dysuria)
- unusual tiredness or weakness
If you think you have taken too much pms-PYRAZINAMIDE, contact your healthcare professional, hospital emergency department or regional poison control center immediately, even if there are no symptoms.
Serious side effects and what to do about them
| Symptom/effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | ||||
| Only if severe | In all cases | |||||
Anaphylactic Reactions (allergic reactions): difficulty breathing, fever, hives, itching, rash, swelling of your tongue or throat | √ | |||||
Hepatotoxicity (injury to the liver): nausea, vomiting, abdominal pain, loss of appetite, diarrhea, tiredness, weakness and jaundice (yellowing of eyes and/or skin) | √ | |||||
Acute Gout: joint pain, swelling, redness and/or warmth in the joints | √ | |||||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
Store in well-closed container at controlled room temperature (15-30°C). Keep out of reach and sight of children.
If you want more information about pms-PYRAZINAMIDE:
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug- products/drug-product-database.html); by contacting the sponsor: Pharmascience Inc. or by calling 1-888-550-6060.
Pharmascience Inc.
Montréal, Québec
H4P 2T4