Tebrazid: Uses, Side Effects and Dosage

What is TEBRAZID used for?

• TEBRAZID is used along with other antituberculosis agents to treat all forms of tuberculosis

  (an infection of the lungs).

• Antibacterial drugs like TEBRAZID treats only bacterial infections. They do not treat viral infections such as the common cold.

How does TEBRAZID work?

TEBRAZID is an antibiotic that works by:

• Stopping the growth of bacteria.
• Killing bacteria
• Reducing the infection

What are the ingredients in TEBRAZID?

Medicinal ingredients: Pyrazinamide

Non-medicinal ingredients: Corn Starch, Silicone Dioxide and Talc.

TEBRAZID comes in the following dosage forms:

500 mg Tablets

Do not use TEBRAZID if:

• You are allergic to any of the ingredients in TEBRAZID.
• You have liver damages.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take TEBRAZID. Talk about any health conditions or problems you may have, including if you:

• Have a condition called gout;
• Have reduced kidney function or other kidney problems;
• Are hypersensitive to ethionamide, isoniazid, niacin (nicotinic acid) or other related medications;
• Have diabetes;

• Are pregnant or are planning to become pregnant;

• Are breastfeeding or planning to breastfeed;

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with TEBRAZID:

• Allopurinol
• Colchicine
• Probenecid
• Sulfinpyrazone
• Cyclosporine

How to take TEBRAZID:

• Swallow TEBRAZID tablets with water.
• You will take TEBRAZID with other antituberculosis drugs.
• Your doctor will decide how much TEBRAZID you should take, when you should take it and for how long you should take it.
• Although you may feel better early in treatment, TEBRAZID should be taken exactly as directed.
• Misuse or overuse of TEBRAZID could lead to the growth of bacteria that will not be killed by TEBRAZID (resistance). This means that TEBRAZID may not work for you in the future.
• Do not share your medicine.

Usual dose

Adult and adolescent dose:

• The dose you are given will be based on your weight. It is usually around 15 to 30 mg per kg of bodyweight once a day or 50 to 70 mg per kg of bodyweight two or three times a week.
• The dose can be different from one person to another.

Pediatric dose:

• The dose you are given will be based on your weight. It is usually around 30 mg per kg of bodyweight or less.
• The dose can be different from one person to another.

Overdose:

If you think you have taken too much TEBRAZID, contact your healthcare professional, hospital emergency department or regional poison control center immediately, even if there are no symptoms.

What are possible side effects from using TEBRAZID?

These are not all the possible side effects you may feel when taking TEBRAZID. If you experience any side effects not listed here, contact your healthcare professional. Side effects may include:

• acne
• painful urination (dysuria)
• unusual tiredness or weakness

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

Store in well-closed container at controlled room temperature (15-30°C).

Keep out of reach and sight of children.

If you want more information about TEBRAZID:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); by contacting the sponsor: Valeant Canada LP, 2150 St-Elzéar Blvd. West, Laval, (Quebec) H7L 4A8; or by calling 1-800-361-4261.

Last Revised: November 23, 2020