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Regiocit: Uses, Side Effects and Dosage

Updated:
Strength:
5.03 g / 5.29 g
Active ingredients:

Patient Medication Information: uses, side effects, how to take - Regiocit

What is REGIOCIT solution used for?

  • Is a solution for hemofiltration and prevents blood clotting during continuous renal replacement therapy (CRRT), which is a form or dialysis treatment. This medicine is used for critically ill patients particularly when other medicine used to prevent blood clotting is not an appropriate choice.

How does REGIOCIT solution work?

This medicine is to be administered into the blood circuit outside of your body when you have CRRT. This medicine is to be used in hospitals and administered by medical professionals only.

What are the ingredients in REGIOCIT solution?

Medicinal ingredients: sodium chloride and sodium citrate

Non-medicinal ingredients: hydrochloric acid, water

REGIOCIT solution comes in the following dosage forms:

Solution with 5.03 g/L of sodium chloride and 5.29 g/L of sodium citrate

Do not use REGIOCIT solution if:

  • You are allergic to any ingredients (See What are the ingredients in REGIOCIT solution).
  • Severely impaired liver function
  • Severely decreased blood flow in the muscles

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take REGIOCIT solution. Talk about any health conditions or problems you may have, including if you:

  • have diabetes
  • have been treated for chronic kidney disease
  • have a history of liver disease

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with REGIOCIT solution:

  • Medicinal products that contain calcium, sodium bicarbonate, or any form of vitamin D.

How to take REGIOCIT solution:

Your healthcare professional will prescribe and administer the product.

Overdose:

If you think you have taken too much REGIOCIT solution, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.

What are possible side effects from using REGIOCIT solution?

These are not all the possible side effects you may feel when taking REGIOCIT solution. If you experience any side effects, contact your healthcare professional.

The following side effects have been associated with other CRRT products:

  • Low Blood Pressure (Hypotension)
  • Low blood calcium, due to excessive and uncorrected effect of citrate in the body (Hypocalcemia)
  • Having an imbalance in your body where you do not have enough magnesium, potassium or phosphate (Electrolyte imbalances, including hypomagnesemia, hypokalemia, hypophosphatemia)
  • Disorder where the pH in your body is not balanced (Acid-base disorders, including metabolic acidosis, metabolic alkalosis)
  • Low Blood Sugar (Hypoglycemia)
  • Having an imbalance in the fluids in your body (Fluid imbalance)

The possible side effects can be resulted from your CRRT procedure:

  • Having an imbalance in your body where you have too much calcium (Hypercalcemia), or do not have enough sodium (Hyponatremia)
  • Having too much fluids (Fluid retention) or not enough fluids in your body (Dehydration)
  • Nausea and vomiting
  • Muscle Spasms

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (http://www.hc-sc.gc.ca/dhp-mps/medeff/report-declaration/index-eng.php) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

Store at 4 °C to 30 °C. Do not freeze or expose to excessive heat.

Keep out of reach and sight of children.

If you want more information about REGIOCIT solution:

•

  • Talk to your healthcare professional

•

  • Find the full product monograph that is prepared for healthcare professionals and

    includes this Patient Medication Information by visiting the Health Canada website (https://health-products.canada.ca/dpd-bdpp/index-eng.jsp); or by calling 1-888-719-9955.

Vantive and Regiocit are trademarks of Vantive Health Inc. or its subsidiaries.

Last Revised: APR 17, 2024

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02496755

Revision date stated in the text: April 17, 2024

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Regiocit

DIN 02496755
Schedule(s) ETHICAL
Active ingredient(s) Sodium chloride 5.03 G, Sodium citrate 5.29 G
Dosage form(s) Solution
Route(s) of administration Extracorporeal
Company VANTIVE ULC
Current status Marketed
Current status date May 6, 2024

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.