Sandoz Dorzolamide/Timolol: Uses, Side Effects and Dosage

What is Sandoz Dorzolamide/Timolol used for?

Sandoz Dorzolamide/Timolol is used to treat high pressure in the eye in patients with the following conditions:

• Ocular hypertension
• Open-angle glaucoma

It is used along with other medicines.

How does Sandoz Dorzolamide/Timolol work?

Sandoz Dorzolamide/Timolol contains a combination of two medicines. One is called a carbonic anhydrase inhibiting medicine. The other is called a beta-blocking medicine. Each one works in a different way to lower the pressure in the eye.

What are the ingredients in Sandoz Dorzolamide/Timolol?

Medicinal ingredients: Each mL contains 20 mg of dorzolamide (as dorzolamide hydrochloride USP) and 5 mg of timolol (as timolol maleate USP).

Non-medicinal ingredients: Benzalkonium chloride (as a preservative), hydroxyethyl cellulose, mannitol, sodium citrate (dihydrate), sodium hydroxide and water for injection.

Sandoz Dorzolamide/Timolol comes in the following dosage forms:

Sandoz Dorzolamide/Timolol are sterile eye drops supplied in a white LDPE plastic DROP-TAINER^® bottle, a white dropper tip and a blue polypropylene cap.

Do not use Sandoz Dorzolamide/Timolol if you:

• are allergic to Sandoz Dorzolamide/Timolol or any of its ingredient. See “What are the ingredients in Sandoz Dorzolamide/Timolol?”
• have serious breathing problems such as asthma
• have chronic obstructive lung disease
• have certain heart conditions such as slow or irregular heartbeats or heart failure
• have severe kidney problems
• are taking medicines called carbonic anhydrase inhibitors by mouth
• are less than 18 years of age

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Sandoz Dorzolamide/Timolol. Talk about any health conditions or problems you may have, including if you:

• have lung or breathing problems such as chronic obstructive lung disease.
• have muscle weakness of the eye.
• have had heart problems such as heart failure in the past.
• have a heart condition called a first degree heart block.
• have an allergy to any medication.

• are pregnant or planning to become pregnant.

• are breast-feeding or planning to breast-feed.
• have or have had kidney problems.
• have or have had liver problems.
• have or have had thyroid problems.
• have or have had blood circulation problems such as Raynaud’s syndrome.
• have or have had diabetes or other blood sugar problems.
• have certain eye problems like corneal defects or have had eye surgery in the past.
• are planning to have major surgery, including eye surgery, as Sandoz Dorzolamide/Timolol may change the effects of some medicines during anesthesia.

Other warnings you should know about:

Contact lenses

If you wear contact lenses, consult your doctor before using Sandoz Dorzolamide/Timolol. Sandoz Dorzolamide/Timolol contains the preservative benzalkonium chloride. It can deposit in soft contact lenses. This means that you must remove your contact lenses before you apply Sandoz Dorzolamide/Timolol. Wait 15 minutes before putting your contact lenses back in your eyes.

Driving and using machines

Wait until you can see clearly before driving or operating machines after applying Sandoz Dorzolamide/Timolol.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with Sandoz Dorzolamide/Timolol:

• Other drugs (including eye drops) that you are using or plan to use.
• Medicines used to lower blood pressure, called calcium channel blockers or clonidine.
• Medicines used to treat heart problems such as quinidine and medicines called beta-blockers.
• Medicines used to treat diabetes such as insulin or oral hypoglycemic agents.
• Medicines used to treat depression called selective serotonin reuptake inhibitors.
• Acetylsalicylic acid used to reduce fever and pain.
• Medicines called sulfa drugs used to treat bacterial infections.

How to take Sandoz Dorzolamide/Timolol:

• Take Sandoz Dorzolamide/Timolol exactly as your healthcare professional has told you to.
• If you are using Sandoz Dorzolamide/Timolol with another eye drop, the drops should be applied at least 10 minutes apart.
• Be careful not to touch your eye, the area around your eye, or any other surface with the tip of the container. It may become contaminated with bacteria. This can cause eye infections. This could lead to serious damage of the eye including loss of vision. Keep the tip of the container away from contact with any surface. Contact your healthcare professional if you think the bottle might be contaminated or if you think you might have an eye infection.
• If you cannot apply Sandoz Dorzolamide/Timolol to yourself a family member or caregiver may help you.

How to Use The DROP-TAINER^®* BOTTLE

The DROP-TAINER^®* bottle is designed to assure the delivery of a precise dose of medication.

Before using your DROP-TAINER^® bottle, read the complete instructions carefully.

1. 1. If you use other topically applied ophthalmic medications, they should be administered at least 10 minutes before or after Sandoz Dorzolamide/Timolol.
2. 2. Wash hands before each use.
3. 3. Before using the medication for the first time, be sure the Safety Seal on the bottle is unbroken.
4. 4. Tear off the Safety Seal to break the seal.
5. 5. Before each use, shake once and remove the screw cap.

1. 6. Invert the bottle and hold the bottle between your thumb and middle finger, with the tips of the fingers pointing towards you.

1. 7. Tilt your head back and position the bottle above the affected eye.

1. 8.

   With the opposite hand, place a finger under the eye. Gently pull down until a “V” pocket is made between your eye and lower lid.

   DO NOT TOUCH THE EYE WITH THE DROPPER TIP.

1. 9.

   With the hand holding the bottle, place your index finger on the bottom of the bottle. Push the bottom of the bottle to dispense one drop of medication.

   DO NOT SQUEEZE THE SIDES OF THE BOTTLE.

   KEEP YOUR HEAD TILTED BACKWARD AND CLOSE YOUR EYE TO ALLOW ABSORPTION OF THE MEDICATION INTO THE EYE.

   After using Sandoz Dorzolamide/Timolol, press a finger into the corner of your eye, by the nose (as shown) for 2 minutes. This helps keep Sandoz Dorzolamide/Timolol in your eye.

1. 10. Repeat steps 6, 7, 8 and 9 with the other eye if instructed to do so by your healthcare professional.
2. 11. Replace screw cap by turning until firmly touching the bottle.

Ophthalmic medications, if handled improperly, can become contaminated by common bacteria known to cause eye infections. Serious damage to the eye and subsequent loss of vision may result from using contaminated ophthalmic medications. If you think that your medication may be contaminated, or if you develop an eye infection, contact your healthcare professional immediately concerning continued use of this bottle.

The dispenser tip is designed to provide a single drop; therefore, do NOT enlarge the hole of the dispenser tip.

After you have used all doses, there will be some Sandoz Dorzolamide/Timolol ophthalmic solution left in the bottle. You should not be concerned since an extra amount of Sandoz Dorzolamide/Timolol ophthalmic solution has been added and you will get the full amount of Sandoz Dorzolamide/Timolol ophthalmic solution that your healthcare professional prescribed. Do not attempt to remove excess medicine from the bottle.

Usual dose:

The usual dose is one drop in the affected eye(s) twice a day.

Your healthcare professional will tell you exactly how much Sandoz Dorzolamide/Timolol you should apply and for how long you should apply it.

Overdose:

If you feel you have taken too much Sandoz Dorzolamide/Timolol and symptoms may include shortness of breath, low heartbeat, dizziness, headache, etc., seek medical help.

If you think you, or a person you are caring for, have taken too much or accidentally swallowed Sandoz Dorzolamide/Timolol, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

Missed Dose:

It is important to apply Sandoz Dorzolamide/Timolol as prescribed by your doctor. If you miss a dose, apply it as soon as possible. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not apply a double dose.

What are possible side effects from using Sandoz Dorzolamide/Timolol?

These are not all the possible side effects you may have when taking Sandoz Dorzolamide/Timolol. If you experience any side effects not listed here, tell your healthcare professional.

Side effects may include:

• Burning, stinging, itching or redness of the eye
• Watery eyes
• Blurred vision
• Swelling or crusting of the eyelids
• Altered sense of taste including a bitter taste
• Muscle pain
• Abdominal pain
• Headache
• Nosebleed
• Dry mouth
• Nausea
• Tiredness

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting Side Effects

Storage:

Store Sandoz Dorzolamide/Timolol at 15 - 25°C. Protect from light.

Keep out of reach and sight of children.

If you want more information about Sandoz Dorzolamide/Timolol:

• Talk to your healthcare professional.
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html), the manufacturer’s website www.sandoz.ca , or by calling 1-800-361-3062.

Last revised: OCT 07, 2026