Patient Medication Information: uses, side effects, how to take - Zyloprim 100
ABOUT THIS MEDICATION
What the medication is used for:
ZYLOPRIM® (allopurinol) is used for:
$ treatment of gout (a painful inflammation primarily of the
big toe),
$ treatment of kidney problems due to high uric acid levels $ treatment or prevention of uric acid deposits in the tissues
or kidneys due to high levels of uric acid in the blood, which may also be caused by certain cancer treatments. $ prevention of uric acid stones or gravel and kidney stone
in patients with high levels of uric acid in blood or urine.
What it does:
ZYLOPRIM® works by reducing the production of uric acid in the body.
When it should not be used:
ZYLOPRIM® should not be used:
$ if you are allergic to the active ingredient allopurinol or
had a previous serious allergic reaction to allopurinol or any ingredient in ZYLOPRIM® (See what the medicinal ingredient is and what the nonmedicinal ingredients are sections).
$ if you are breastfeeding.
$ if you are less than 18 years old (except in children with
hyperuricemia (a high level of uric acid in the blood secondary to cancerous growths).
What the medicinal ingredient is:
The medicinal ingredient in ZYLOPRIM® is allopurinol.
What the important nonmedicinal ingredients are:
ZYLOPRIM® contains the following nonmedicinal ingredients: starch, lactose, magnesium stearate, povidone. In addition, the 300 mg tablets contain FD&C Yellow #6 Lake.
What dosage forms it comes in:
ZYLOPRIM® is available as 100 mg, 200 mg and 300 mg tablets.
WARNINGS AND PRECAUTIONS
BEFORE you use ZYLOPRIM® talk to your doctor or pharmacist if:
- you are allergic to allopurinol or any other medications.
- you have or have ever had kidney or liver disease or heart disease.
- you are pregnant, plan to become pregnant, or are breastfeeding.
Gout attacks may occur at the start of treatment. Do not drive or operate machinery if feeling sleepy or drowsy.
INTERACTIONS WITH THIS MEDICATION
Tell your doctor what prescription and non-prescription medications, vitamins, nutritional supplements and herbal products you are taking, especially:
chemotherapy agents
coumarin, anticoagulants
amoxicillin/ampicillin
chlorpropamide
didanosine
phenytoin
theophylline
salicylates and uricosurics
probenecid
cyclosporin
vidarabine
PROPER USE OF THIS MEDICATION
Usual dose:
Adults
General:
The total daily requirement should be divided into 1 to 3 doses. Daily doses up to and including 300 mg ZYLOPRIM® may be taken once a day after a meal. You should drink plenty of fluids while taking ZYLOPRIM®.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ZYLOPRIM® exactly as directed. Do not take more or less than prescribed by your doctor.
Overdose:
You should immediately contact either your doctor, your hospital emergency department or the nearest poison control centre.
Symptoms and signs of overdosage include nausea, vomiting, diarrhea and dizziness.
IMPORTANT: PLEASE READ
DCTM/219/521/2006-07-04-131-pm-pristine-ZYLOPRIM.doc
Page 19 of 19 Missed Dose:
If you forget to take your medicine, take it as soon as you
remember. However, if it is almost time for the next dose,
skip the missed dose and continue your regular dosing
schedule. Do not take a double dose to make up for a missed
dose.
| SERIOUS SIDE EFFECTS, HOW OFTEN THEY HAPPEN AND WHAT TO DO ABOUT THEM | ||||
| Frequency | Side effect/ Symptom | Talk with your doctor or pharmacist | Stop taking drug and call your doctor or pharmacist | |
Only if severe | In all cases | |||
| Common | Skin rash and hypersensitivity reactions (serious allergic reactions) | 9 | 9 | |
| Uncommon | Drowsiness, diarrhea, abdominal pain, nausea, vomiting. | 9 | 9 | |
This is not a complete list of side effects. For any unexpected effects while taking ZYLOPRIM®, contact your doctor or pharmacist.
Gout attacks may occur at the start of treatment
HOW TO STORE IT
ZYLOPRIM® should be stored between 15 and 30°C, out of the reach of children.
REPORTING SUSPECTED SIDE EFFECTS
To monitor drug safety, Health Canada collects information on serious and unexpected effects of drugs . If you suspect you have had a serious or unexpected reaction to this drug you may notify Health Canada by:
toll-free telephone: 866-234-2345 toll-free fax 866-678-6789
By email: cadrmp@hc-sc.gc.ca
By regular mail:
National AR Centre
Marketed Health Products Safety and Effectiveness Information Division
Marketed Health Products Directorate
Tunney’s Pasture, AL 0701C
Ottawa ON K1A 0K9
NOTE: Before contacting Health Canada, you should contact your physician or pharmacist.
MORE INFORMATION
This document plus the full product monograph, prepared for health professionals can be found by contacting the sponsor, GlaxoSmithKline Inc.
7333 Mississauga Road
Mississauga, Ontario
L5N 6L4
1-800-387-7374
Last revised: July 05, 2006
© 2006 GlaxoSmithKline Inc. All Rights Reserved
®ZYLOPRIM is a registered trademark, used under license by GlaxoSmithKline Inc.