Anzupgo: Uses, Side Effects and Dosage

What ANZUPGO is used for:

ANZUPGO is used in adults to treat moderate to severe chronic hand eczema (CHE). It is used when other skin creams (corticosteroids) do not work well enough or cannot be used.

How ANZUPGO works:

ANZUPGO belongs to a group of medicines called Janus kinase (JAK) inhibitors. It works by reducing the activity of enzymes in the body called ‘Janus kinases’. This can help reduce skin inflammation, itching, and pain.

The ingredients in ANZUPGO are:

Medicinal ingredient(s): Delgocitinib.

Non-medicinal ingredients: Benzyl alcohol, butylhydroxyanisole, cetostearyl alcohol, citric acid monohydrate, disodium edetate, hydrochloric acid, liquid paraffin, macrogol cetostearyl ether, and purified water.

ANZUPGO comes in the following dosage form(s):

Cream (white to slightly brown): 20 mg/g of delgocitinib.

Do not use ANZUPGO if:

• you are allergic to delgocitinib or any of the other ingredients in ANZUPGO.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take ANZUPGO. Talk about any health conditions or problems you may have, including if you:

• are taking other medicine for your hand eczema.

• are pregnant, think you may be pregnant, or are planning to have a baby. The effects of ANZUPGO are not known in pregnant women. ANZUPGO should be avoided if you are pregnant or think you may be pregnant.

• are breast-feeding or are planning to breast-feed. It is not known whether delgocitinib passes into human breast milk. If you are breast-feeding, ensure that the ANZUPGO

  • cream does not come into contact with your nipple or any other surrounding areas where your baby may ingest it during feeding.
• have a history of skin cancer or are at a higher risk for skin cancer. Patients taking JAK inhibitors, the class of medicines to which ANZUPGO belongs, have reported cases of a type of skin cancer called ‘non-melanoma skin cancer’. Your healthcare professional may recommend regular skin examinations before and while using ANZUPGO.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with ANZUPGO:

• Other topical medicines that are used on the same area of the skin as ANZUPGO.

How to take ANZUPGO:

• Always use this medicine exactly as your healthcare professional has told you. Check with your healthcare professional if you are not sure.
• ANZUPGO is for use on the skin only. Avoid contact with your eyes, mouth, nose, or vagina. If the cream gets on any of these areas, thoroughly wipe off and/or rinse off the cream with water.
• Avoid applying other topical products, such as creams, ointments, or other medications, to the same area of the skin within 2 hours before and after applying ANZUPGO.
• If someone else applies this medicine to your skin, they should wash their hands after application.
• If your skin does not improve after 12 weeks of treatment with ANZUPGO, talk to your healthcare professional.
• Do not use more than one tube of ANZUPGO (60 g) per month.
• The tube has a seal at the top end of the tube. Peel off this seal before you first use the ANZUPGO cream.

Usual dose:

• A thin layer of ANZUPGO should be applied two times a day (about 12 hours apart) to the affected skin of the hands and wrists. Before you apply the cream, make sure the affected areas of your skin are clean and dry.
• You should use ANZUPGO until your skin has become clear or almost clear, or as directed by your healthcare professional.
• If signs or symptoms of chronic hand eczema reappear, your healthcare professional may restart your treatment with ANZUPGO.

Overdose:

If too much ANZUPGO has been applied, the excess should be wiped off.

Missed dose:

If you miss or forget to apply the cream, do it as soon as possible. Then apply your next dose at the regularly scheduled time. If you have any questions, ask your healthcare professional.

Possible side effects from using ANZUPGO:

These are not all the possible side effects you may have when taking ANZUPGO. If you experience any side effects not listed here, tell your healthcare professional.

The following side effects have been reported with ANZUPGO:

Common (may affect up to 1 in 10 people):

• application site reactions (i.e., pain, itching, redness, and tingling).

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting side effects

Storage:

• Store below 30°C. Do not freeze.
• 15 g (sample) and 60 g tube sizes: Use within 12 months of first opening the tube and not past the expiry date, which is stated on the tube and carton. The expiry date refers to the last day of that month.
• 5 g (sample) tube size: Use within 1 week of first opening the tube and not past the expiry date, which is stated on the tube and carton. The expiry date refers to the last day of that month.
• Keep out of reach and sight of children.

If you want more information about ANZUPGO:

• Talk to your healthcare professional.
• Find the full Product Monograph that is prepared for healthcare professionals and includes the Patient Medication Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website (www.leo-pharma.ca); or by calling 1-800-263-4218.

Date of Authorization: 2026-09-24

ANZUPGO ^® is a registered trademark of LEO Pharma A/S used under license by LEO Pharma Inc. Canada