Patient Medication Information: uses, side effects, how to take - Atridox
What is ATRIDOX used for?
- ATRIDOX is used in adults to treat inflammation (swelling) of the tissue around the teeth called “periodontitis”.
- Antibacterial drugs like ATRIDOX treat only bacterial infections. They do not treat viral infections.
How does ATRIDOX work?
ATRIDOX is a gel that is injected by your dentist into the periodontal pocket (the space between your gums and your teeth). ATRIDOX contains doxycycline, a tetracycline antibiotic, that stops the growth of bacteria. Reducing the amount of bacteria in the periodontal pocket can help treat “periodontitis”.
What are the ingredients in ATRIDOX?
Medicinal ingredients: doxycycline hyclate
Non-medicinal ingredients: DOXYGEL Delivery System (63.3% N-methyl-2-pyrrolidone and 36.7% poly(DL-lactide))
ATRIDOX comes in the following dosage forms:
Controlled-release gel: 8.8% w/w
Do not use ATRIDOX if you:
- are allergic (hypersensitive) to doxycycline or any other tetracycline antiobiotic.
are pregnant.
- are breastfeeding.
- are under the age of 18 (ATRIDOX should not be used during tooth development).
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take ATRIDOX. Talk about any health conditions or problems you may have, including if you:
- have a history of liver failure.
- are sensitive to sunlight, have a history of sunburns, or are exposed to direct sunlight (or ultraviolet light) on a regular basis.
- have diabetes.
- are receiving chemotherapy or radiation treatment.
- have HIV infection.
- have or have a history of thrush (a yeast infection in your mouth).
- have dental implants or are going to be getting dental implants.
Other warnings you should know about:
Using tretracycline antibiotics, including ATRIDOX, during tooth development may cause permanent discolouration of the teeth. ATRIDOX is therefore only to be used in adults. ATRIDOX is not to be used during pregnancy or while breastfeeding.
In the area(s) where your dentist has injected ATRIDOX you should not brush or flossing for seven days.
ATRIDOX can cause your skin to become sensitive to the sun and UV light. You should avoid exposure to direct sunlight and UV light while you are being treated with ATRIDOX. If you are going to be exposed to sunlight or UV light while you are being treated with ATRIDOX you must wear protective clothing. If you get a sunburn or notice any skin reddening while you are being treated with ATRIDOX contact your healthcare professional immediately.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with ATRIDOX:
- anticoagulant medications used to thin the blood and prevent blood clots.
- methoxyflurane anesthesia used to control pain in emergency settings.
- hormonal birth control (such as pills, patch or ring). ATRIDOX may decrease the effectiveness of hormonal birth control.
How to take ATRIDOX:
Your healthcare professional will administer ATRIDOX.
- Although you may feel better early in treatment, ATRIDOX should be used exactly as directed.
- Misuse or overuse of ATRIDOX could lead to the growth of bacteria that will not be killed by ATRIDOX (resistance). This means that ATRIDOX may not work for you in the future.
- Do not share your medicine.
Usual adult dose:
Your dentist will decide how many periodontal pockets to treat and how much ATRIDOX to use.
Overdose:
Overdose with ATRIDOX is unlikely due to the small doses used however, if you think you have been given too much ATRIDOX, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.
What are possible side effects from using ATRIDOX?
These are not all the possible side effects you may feel when taking ATRIDOX. If you experience any side effects not listed here, contact your healthcare professional.
Side effects may include:
- Gum discomfort/pain/soreness, gum swelling
- Bleeding gums
- Mouth sores, mouth pain
- Toothache
- Tooth sensitivity to hot/cold
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
| Only if severe | In all cases | ||
| Allergic reaction: rash, hives, swelling of the face, lips, tongue or throat, difficulty swallowing or breathing | √ | ||
| Periodontal abscess (infection): deep, throbbing pain, red and swollen gum that is painful to touch, pus or other discharge from around the tooth, jaw pain | √ | ||
| Loose teeth or tooth loss | √ | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
- Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
- Calling toll-free at 1-866-234-2345.
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.
Storage:
Your healthcare professional will store ATRIDOX at 2–8 °C. After it is prepared, it is stored at room temperature (15–30°C) for up to three days.
If you want more information about ATRIDOX:
- Talk to your healthcare professional
Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website
https://www.canada.ca/en/health-canada.html) or by calling 905-820-3475.
Manufacturer:
Den-Mat Holdings, LLC
1017 W. Central Ave.
Lompoc, CA 93436 U.S.A.
Imported by:
Radiant Global Logistics
1280 Courtneypark Dr E
Mississauga, ON L5T 1N6
Distributed by:
Henry Schein
345 Townline Rd
Niagara on the Lake,
ON, L0S 1J0, CA