Patient Medication Information: uses, side effects, how to take - Daptomycin for Injection (Accord Healthcare)
What is Daptomycin for Injection used for?
Daptomycin for Injection is used in adults (18 years and older) to treat bacterial infections:
- of the skin and soft tissues (e.g. fascia or muscle layers)
- in the blood, including certain heart valve infections (native valve, right-sided infective endocarditis)
Antibacterial drugs like Daptomycin for Injection treat only infections caused by bacteria. They do not treat viral infections. Although you may feel better early in treatment,
Daptomycin for Injection should be used exactly as directed. Misuse or overuse of
Daptomycin for Injection could lead to growth of bacteria that will not be killed by
Daptomycin for Injection (resistance). This means that Daptomycin for Injection may not work for you in the future.
How does Daptomycin for Injection work?
Daptomycin for Injection are antibiotics. They work by killing certain bacteria that cause your infection.
What are the ingredients in Daptomycin for Injection?
Medicinal ingredients: Daptomycin
Non-medicinal ingredients: Sodium hydroxide
Daptomycin for Injection comes in the following dosage forms:
Lyophilized powder for solution available as 500 mg/20 mL
Do not use Daptomycin for Injection if:
- you are allergic to daptomycin.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Daptomycin for Injection. Talk about any health conditions or problems you may have, including if you:
- have kidney or severe liver problems.
- have high blood levels of creatine phosphokinase (CPK).
are pregnant, or planning on becoming pregnant.
- are breastfeeding or plan to breastfeed. Breastfeeding should be stopped during treatment with Daptomycin for Injection.
- are allergic to any antibiotics or other drugs.
- are taking other medications (see The following may interact with Daptomycin for Injection).
- have any questions about your treatment, both before and during treatment.
Other warnings you should know about:
Stop taking Daptomycin for Injection and contact your doctor right away if you:
have severe or lasting diarrhea (bloody or watery) with or without
- fever.
- stomach pain or tenderness.
You may have Clostridium difficile colitis (bowel inflammation).
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with Daptomycin for Injection:
Drugs that lower cholesterol (HMG-CoA reductase inhibitors also known as “statins” such as
atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, and simvastatin)
- Tobramycin (another antibiotic)
- Blood thinners (warfarin)
How to take Daptomycin for Injection:
Daptomycin for Injection will be given intravenously (injected into a vein) by a doctor or nurse in a hospital or clinical setting.
Usual dose:
Serious skin infections: The usual adult dose is 4 mg for every kg of body weight. Your dose will be given either as an injection over a 2-minute period or by infusion over a 30-minute period every 24 hours for 7 to 14 days.
Bacterial infections in the blood, including certain heart valve infections: The usual adult dose is 6 mg for every kg of body weight. Your dose will be given either as an injection over a 2-minute period or by infusion over a 30-minute period every 24 hours for 10 to 56 days.
Use in children: Daptomycin for Injection is not recommended for use in patients under the age of 18 years.
Overdose:
| If you think you have taken too much Daptomycin for Injection, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms. |
What are possible side effects from using Daptomycin for Injection?
These are not all the possible side effects you may feel when taking Daptomycin for Injection. If you experience any side effects not listed here, contact your healthcare professional.
Common side effects may include:
- headache or dizziness.
- diarrhea or constipation.
- nausea or vomiting.
- rash or itching.
- difficulty sleeping.
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
| Only if severe | In all cases | ||
UNCOMMON A serious allergic reaction with symptoms such as:
| X | ||
Pain in the hands and feet with symptoms such as:
| X | ||
| Irregular heartbeat | X | ||
Kidney problems with symptoms such as:
| X | ||
VERY RARE Respiratory problems with symptoms such as:
| X | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
Daptomycin for Injection vials containing lyophilized powder should be stored at 2ºC to 8ºC.
Reconstituted solutions are to be used immediately or refrigerated (2ºC to 8ºC) and used within
72 hours, then discarded. Health Care professionals should refer to the Product Monograph for more details.
Keep out of reach and sight of children.
If you want more information about Daptomycin for Injection:
- Talk to your healthcare professional
- Find this document plus the full product monograph, prepared for health professionals by visiting the Health Canada website at: https://health-products.canada.ca/dpd-bdpp/index-eng.jsp or by calling the sponsor Accord Healthcare Inc. at 1-866-296-0354.
Accord Healthcare Inc.
3535 boul. St. Charles Suite 704
Kirkland, QC, H9H 5B9
Canada