Patient Medication Information: uses, side effects, how to take - Daptomycin for Injection (Sandoz Canada)
What is Daptomycin for Injection?
Daptomycin for Injectionis used to treat bacterial infections:
- of the skin and soft tissues (patients 1 year and older)
- in the blood (patients 1 year and older)
- certain heart valve infections (patients 18 years and older)
Antibacterial drugs like Daptomycin for Injection treat only infections caused by bacteria. They do not treat viral infections. Although you may feel better early in treatment, Daptomycin for Injection should be used exactly as directed. Misuse or overuse of Daptomycin for Injection could lead to growth of bacteria that will not be killed by Daptomycin for Injection (resistance). This means that Daptomycin for Injection may not work for you in the future.
How does Daptomycin for Injection work?
Daptomycin for Injection is an antibiotic. It works by killing certain bacteria that cause your infection.
What are the ingredients in Daptomycin for Injection?
Medicinal ingredient: Daptomycin
Non-medicinal ingredient: Sodium hydroxide
Daptomycin for Injection comes in the following dosage forms:
Lyophilized powder for solution available as 500 mg/20 mL vial
Do not use Daptomycin for Injection if:
- you are allergic to daptomycin.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Daptomycin for Injection. Talk about any health conditions or problems you may have, including if you:
- have kidney or severe liver problems.
- have high blood levels of creatine phosphokinase (CPK).
are pregnant, or planning on becoming pregnant.
are breastfeeding or plan to breastfeed. Breastfeeding should be stopped during treatment
- with Daptomycin for Injection.
- are allergic to any antibiotics or other drugs.
- are taking other medications (see The following may interact with Daptomycin for Injection).
- have any questions about your treatment, both before and during treatment.
Other warnings you should know about:
Stop taking Daptomycin for Injection and contact your doctor right away if you:
have severe or lasting diarrhea (bloody or watery) with or without
- fever.
- stomach pain or tenderness.
You may have Clostridium difficile colitis (bowel inflammation).
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with Daptomycin for Injection:
- Drugs that lower cholesterol (HMG-CoA reductase inhibitors also known as “statins” such as atorvastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin, and simvastatin)
- Tobramycin (another antibiotic)
- Blood thinners (warfarin)
How to take Daptomycin for Injection:
Daptomycin for Injection will be given intravenously (injected into a vein) by a doctor or nurse in a hospital or clinical setting.
Usual dose:
Adults:
Serious skin infections: The usual adult dose is 4 mg for every kg of body weight. Your dose will be given either as an injection over a 2-minute period or by infusion over a 30-minute period every 24 hours for 7 to 14 days.
Bacterial infections in the blood, including certain heart valve infections: The usual adult dose is 6 mg for every kg of body weight. Your dose will be given either as an injection over a 2-minute period or by infusion over a 30-minute period every 24 hours for 10 to 56 days.
Children:
Your doctor will decide how much Daptomycin for Injection to give your child based on their age, weight and type of infection.
Serious skin infections:
| Age Group | Dosage | Duration of Therapy |
| 12 to 17 years | 5 mg/kg once every 24 hours infused over 30 minutes |
| Up to 14 days | |
| 7 to 11 years | 7 mg/kg once every 24 hours infused over 30 minutes |
| 2 to 6 years | 9 mg/kg once every 24 hours infused over 60 minutes |
| 1 to less than 2 years | 10 mg/kg once every 24 hours infused over 60 minutes |
Bacterial infections in the blood:
| Age Group | Dosage | Duration of Therapy |
| 12 to 17 years | 7 mg/kg once every 24 hours infused over 30 minutes | Up to 42 days |
| 7 to 11 years | 9 mg/kg once every 24 hours infused over 30 minutes | |
| 1 to 6 years | 12 mg/kg once every 24 hours infused over 60 minutes | |
Overdose:
| If you think you have taken too much Daptomycin for Injection, contact your healthcare professional, hospital emergency department or regional Poison Control Centre immediately, even if there are no symptoms. |
What are possible side effects from using Daptomycin for Injection?
These are not all the possible side effects you may feel when taking Daptomycin for Injection. If you experience any side effects not listed here, contact your healthcare professional.
Common side effects may include:
- headache or dizziness.
- diarrhea or constipation.
- nausea or vomiting.
- rash or itching.
- difficulty sleeping.
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help |
| Only if severe | In all cases | |
UNCOMMON A serious allergic reaction with symptoms such as:
| ||
| ✓ | ||
| |||
Pain in the hands and feet with symptoms such as:
| ✓ | ||
| Irregular heartbeat | ✓ | ||
Kidney problems with symptoms such as:
| ✓ | ||
VERY RARE Respiratory problems with symptoms such as:
| ✓ | ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
Daptomycin for Injection vials containing lyophilized powder should be stored at 2 to 8ºC.
Reconstituted solutions are to be used immediately or refrigerated (2 to 8ºC) and used within 72 hours, then discarded. Health Care professionals should refer to the Product Monograph for more details.
Keep out of reach and sight of children.
If you want more information about Daptomycin for Injection:
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://health-products.canada.ca/dpd-bdpp/index-eng.jsp); Sandoz Canada Inc.’s website www.sandoz.ca, or by calling 1-800-361-3062.
Sandoz Canada Inc.
Boucherville, Québec
Canada J4B 1E6
medinfo@sandoz.com
Questions or concerns: 1-800-361-3062