Mar-Glycopyrrolate: Uses, Side Effects and Dosage

What is MAR-GLYCOPYRROLATE used for?

MAR-GLYCOPYRROLATE is used for reducing drooling caused by certain health problems. It is for patients that are 3-18 years old.

How does MAR-GLYCOPYRROLATE work?

MAR-GLYCOPYRROLATE reduces the rate of drooling. This is done by blocking receptors on the glands that make saliva.

What are the ingredients in MAR-GLYCOPYRROLATE?

Medicinal ingredients: Glycopyrrolate

Non-medicinal ingredients: Citric acid monohydrate, cherry flavor, glycerol, liquid sorbitol, methyl parahydroxybenzoate, propyl parahydroxybenzoate, propylene glycol, purified water, saccharin sodium, sodium citrate.

Composition of Cherry Flavour: Natural Anisyl Acetate, Natural Benzaldehyde, Natural Benzyl Acetate, Natural Benzyl Alcohol, Natural Cinnamaldehyde, Natural Ethyl Acetate, Natural Ethyl Butyrate, Natural gamma-Undecalactone, Natural Geraniol, Natural Isoamyl Butyrate, Natural Isobutyl Acetate, Natural Maltol, Natural p-Anisaldehyde, Natural Raspberry Ketone, Tolu Balsam, Propylene Glycol

MAR-GLYCOPYRROLATE comes in the following dosage form:

Oral solution, 1 mg/5 mL.

Do not use MAR-GLYCOPYRROLATE if your child:

• is allergic to glycopyrrolate or any of the other ingredients.
• has an eye problem where the pressure inside the eye is too high (glaucoma).
• has a blockage or backward flow of urine drainage from the kidney, ureter, or bladder.
• has a blockage that keeps food or liquid from passing through the small or large intestine.
• has a blockage in the intestine due to either paralysis or weakening of the intestinal muscles.
• has unstable cardiovascular status.
• has severe ulcerative colitis with or without other serious bowel problems.
• has a disease that makes the voluntary muscles more weak and tired.
• is taking a solid oral form (e.g. a tablet) of potassium chloride.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you give your child MAR-GLYCOPYRROLATE. Talk about any health conditions or problems you may have, including if your child:

• has any stomach or bowel problems, including ulcerative colitis.
• has any problems with constipation.
• has any problems with diarrhea.
• has thyroid problems.
• has high blood pressure.
• has heart problems or abnormal heart beats.
• has a hiatal hernia with gastroesophageal reflux disease (GERD).
• has any problems urinating.
• has any other medical conditions.

• is pregnant or plans to become pregnant. It is not known if MAR-GLYCOPYRROLATE can harm an unborn baby.

• is breastfeeding or plans to breastfeed. It is not known if MAR-GLYCOPYRROLATE passes into breast milk and if it can harm the baby.
• has kidney problems.
• has poorly controlled mental conditions and/or seizures.

Other warnings you should know about:

MAR-GLYCOPYRROLATE can cause your child to sweat less. Your child can become overheated. If your child is in an area that is very hot, they may develop heat stroke.

MAR-GLYCOPYRROLATE may cause sleepiness or blurred vision. Your child should not drive a car or operate heavy machinery. Your child should not do other risky activities while taking MAR-GLYCOPYRROLATE.

Tell your healthcare professional about all the medicines your child takes, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with MAR-GLYCOPYRROLATE:

• anticholinergic agents (diphenhydramine, phenothiazines, tricyclic antidepressants)
• amatandine
• atenolol
• cannabinoids (dronabinol, nabilone)
• digoxin
• haloperidol
• levodopa
• metformin

• monoamine oxidase inhibitors (e.g. moclobemide, phenelzine, procarbazine, rasagiline,

  • selegiline, tranylcypromine)
• solid oral dosage forms of potassium chloride

Ask your healthcare provider or pharmacist if you are not sure if a medicine your child takes is one that is listed above.

How to give MAR-GLYCOPYRROLATE:

• Give 1 hour before or 2 hours after meals.

• Give exactly as prescribed by your child’s doctor. Do not change the dose of MAR-GLYCOPYRROLATE unless your doctor tells you to.
• Pour the approximate dose into a specially marked dose measuring cup, then use an oral syringe to accurately measure the correct amount of MAR-GLYCOPYRROLATE. Dosing cups and oral syringes are available at most pharmacies. DO NOT insert the oral syringes into the bottle.
• For questions on how to measure the dose or use an oral syringe, ask your pharmacist or doctor.
• Administer the dose using the oral syringe. Make sure that your child swallows the dose.
• Thoroughly wash the syringe and dose cup with warm water after each use.
• Any unused solution remaining in the dose cup should be discarded after each use.
• The syringe and dose cup should be clean and dry prior to each use.
• Discard 30 days after opening the bottle.

Usual dose:

Your doctor will tell you how much MAR-GLYCOPYRROLATE (millilitres or mLs) to give your child. The usual starting dose is 0.02 mg/kg orally three times daily. Your doctor will adjust the dose over time based on your child’s response and side effects. The maximum recommended dose is 0.1 mg/kg three times daily and should not be greater than 1.5 – 3 mg (7.5 mL – 15 mL) per dose based upon weight.

Overdose:

MAR-GLYCOPYRROLATE contains benzyl alcohol (0.1 mg/5 ml). Overdosage may result in serious adverse effects.

Missed Dose:

If you miss giving a dose of MAR-GLYCOPYRROLATE to your child and it is:

• within 2 hours of the usual dose time, give your child the missed dose immediately, unless a meal has been eaten within the last 2 hours. Do not feed your child a meal for 1 hour after giving them MAR-GLYCOPYRROLATE.
• more than 2 hours since the usual dose time, do not give your child the missed dose. Give the next

If you think you , or a person you are caring for, have taken too much MAR-GLYCOPYRROLATE , contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

• dose at the regular dose time.

Do not give your child a double dose to make up for a forgotten dose.

What are possible side effects from using MAR-GLYCOPYRROLATE?

These are not all the possible side effects you may feel when taking MAR-GLYCOPYRROLATE. If you experience any side effects not listed here, contact your healthcare professional. Please also see Other warnings you should know about.

The most common side effects of MAR-GLYCOPYRROLATE include:

• dry mouth.
• vomiting.
• constipation.
• flushing of the face or skin.
• headache.
• problem urinating, difficulty starting urination.
• rapid heart beat.

Serious side effects and what to do about them

If your child has a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your child’s daily activities, talk to your healthcare professional.

Storage:

Store at 15°C - 25°C. Do not refrigerate or freeze. Discard 30 days after first opening.

Keep MAR-GLYCOPYRROLATE out of reach and sight of children.

If you want more information about MAR-GLYCOPYRROLATE:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada Drug Product Database website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website www.marcanpharma.com or by calling 1-855-627-2261.

Last revised: OCT 23, 2026

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting (canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.