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PDP-Pyrazinamide: Uses, Side Effects and Dosage

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Facts
Status:
Prescription (Rx)
Strength:
500 mg
Active ingredient:
ATC code:
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Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - PDP-Pyrazinamide

What is pdp-PYRAZINAMIDE used for?

  • pdp-PYRAZINAMIDE is used along with other antituberculosis agents to treat all forms of tuberculosis (an infection of the lungs).
  • Antibacterial drugs like pdp-PYRAZINAMIDE treats only bacterial infections. They do not treat viral infections such as the common cold.

How does pdp-PYRAZINAMIDE work?

pdp-PYRAZINAMIDE is an antibiotic that works by:

  • Stopping the growth of bacteria.
  • Killing bacteria
  • Reducing the infection

What are the ingredients in pdp-PYRAZINAMIDE?

Medicinal ingredients: Pyrazinamide

Pregelatinized Starch, Corn Starch, Microcrystalline Cellulose, Stearic Acid, Colloidal Silicon Dioxide

pdp-PYRAZINAMIDE comes in the following dosage forms:

500 mg Tablets

Do not use pdp-PYRAZINAMIDE if:

  • You are allergic to any of the ingredients in pdp-PYRAZINAMIDE.
  • You have liver damages.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take pdp-PYRAZINAMIDE. Talk about any health conditions or problems you may have, including if you:

  • Have a condition called gout;
  • Have reduced kidney function or other kidney problems;
  • Are hypersensitive to ethionamide, isoniazid, niacin (nicotinic acid) or other related medications;
  • Have diabetes;

  • Are pregnant or are planning to become pregnant;

  • Are breastfeeding or planning to breastfeed;

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with pdp-PYRAZINAMIDE:

  • Allopurinol
  • Colchicine
  • Probenecid
  • Sulfinpyrazone
  • Cyclosporine

How to take pdp-PYRAZINAMIDE:

  • Swallow pdp-PYRAZINAMIDE tablets with water.
  • You will take pdp-PYRAZINAMIDE with other antituberculosis drugs.
  • Your doctor will decide how much pdp-PYRAZINAMIDE you should take, when you should take it and for how long you should take it.
  • Although you may feel better early in treatment, pdp-PYRAZINAMIDE should be taken exactly as directed.
  • Misuse or overuse of pdp-PYRAZINAMIDE could lead to the growth of bacteria that will not be killed by pdp-PYRAZINAMIDE (resistance). This means that pdp-PYRAZINAMIDE may not work for you in the future.
  • Do not share your medicine.

Usual dose

Adult and adolescent dose:

  • The dose you are given will be based on your weight. It is usually around 15 to 30 mg per kg of bodyweight once a day or 50 to 70 mg per kg of bodyweight two or three times a week.
  • The dose can be different from one person to another.

Pediatric dose:

  • The dose you are given will be based on your weight. It is usually around 30 mg per kg of bodyweight or less.
  • The dose can be different from one person to another.

Overdose:

What are possible side effects from using pdp-PYRAZINAMIDE?

These are not all the possible side effects you may feel when taking pdp-PYRAZINAMIDE If you experience any side effects not listed here, contact your healthcare professional.

Side effects may include:

  • acne
  • painful urination (dysuria)
  • unusual tiredness or weakness

Serious side effects and what to do about them

If you think you have taken too much pdp-PYRAZINAMIDE, contact your healthcare professional, hospital emergency department or regional poison control center immediately, even if there are no symptoms.

Symptom/effect

Talk to your healthcare

professional

Stop taking drug and get immediate medical help
Only if severeIn all cases

Anaphylactic Reactions (allergic

reactions): difficulty breathing, fever, hives, itching, rash, swelling of your tongue or throat

√

Hepatotoxicity (injury to the liver):

nausea, vomiting, abdominal pain, loss of appetite, diarrhea, tiredness, weakness and jaundice (yellowing of eyes and/or skin)

√

Acute Gout: joint pain, swelling,

redness and/or warmth in the joints

√

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storage:

Store in well-closed container at controlled room temperature (15-30°C). Keep out of reach and sight of children.

If you want more information about pdp-PYRAZINAMIDE:

  • Talk to your healthcare professional
  • Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug- products/drug-product-database.html); by contacting the sponsor: Pendopharm division of Pharmascience Inc. or by calling 1-888-550-6060.

Pendopharm, division of Pharmascience Inc.

Montréal, Québec

H4P 2T4

Last Revised: August 23, 2019

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 00618810

Revision date stated in the text: August 23, 2019

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for PDP-Pyrazinamide

Rx or OTC
Prescription (Rx)?
DIN 00618810
Schedule(s) PRESCRIPTION
Active ingredient(s) Pyrazinamide 500 MG
Dosage form(s) Tablet
Route(s) of administration Oral
Drug class (WHO ATC)
  1. J Antiinfectives for systemic use
    1. J04 Antimycobacterials
      1. J04A Drugs for treatment of tuberculosis
        1. J04AK Other drugs for treatment of tuberculosis
          1. J04AK01 Pyrazinamide
Company PENDOPHARM DIVISION OF PHARMASCIENCE INC
Current status Marketed
Current status date March 5, 2014

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.