Pred Mild: Uses, Side Effects and Dosage

What is PRED MILD used for?

PRED MILD is used to treat eye problems that are not infectious (cannot be spread from one person to another). This includes allergies, inflammation (swelling) and burns caused by chemicals and heat.

How does PRED MILD work?

PRED MILD is a type of corticosteroid medicine that treats inflammation. It works by reducing the swelling, irritation, burning, redness and other symptoms seen with eye inflammation.

What are the ingredients in PRED MILD?

Medicinal ingredients: prednisolone acetate

Non-medicinal ingredients: benzalkonium chloride, boric acid, edetate disodium, hydroxypropyl methylcellulose, polysorbate 80, purified water, sodium metabisulphite, sodium chloride, sodium citrate dihydrate, hydrochloric acid and/or sodium hydroxide.

PRED MILD comes in the following dosage forms:

Ophthalmic suspension, 0.12% w/v

Do not use PRED MILD if you:

• are allergic (hypersensitive) to prednisolone acetate, any other corticosteroids or any of the other ingredients in PRED MILD.
• have a viral infection of the eye such as; herpes, vaccinia or chickenpox.
• have a mycobacterial infection of the eye such as; tuberculosis.
• have a fungal infection of the eye.
• have any infection of the eye that causes pus.

To help avoid side effects and ensure proper use, talk to your healthcare professional before you use PRED MILD. Talk about any health conditions or problems you may have, including if you:

• are pregnant or planning to become pregnant

• are breast-feeding or planning to breast-feed
• have asthma
• have glaucoma (increased pressure in your eye)
• have recently had cataract surgery
• have a history of herpes infection in your eye
• have any other eye conditions

Other warnings you should know about:

Use with contact lenses

PRED MILD contains a preservative called benzalkonium chloride which may discolor soft contact lenses. If you wear contact lenses, remove them before using PRED MILD. Wait 15 minutes after using the drops before you put your lenses back in.

Serious Allergic Reactions

PRED MILD contains sodium metabisulphite, a sulphite that may cause a serious allergic reaction that can be life-threatening. If you have asthma you may be more likely to have this type of allergic reaction. While you are taking PRED MILD if you develop a rash, hives, swelling of the face, lips, tongue or throat or have difficulty breathing or swallowing stop using PRED MILD and seek immediate medical help.

Driving and Using Machines

Using PRED MILD may temporarily blur your vision. Do not drive or use machines until your vision has cleared.

Eye and Vision Problems

Using corticosteroids, like PRED MILD, may cause eye and vision problems, such as blurred vision, vision loss, increased pressure in your eye (glaucoma), cataracts and other serious conditions. Eye drops containing corticosteroids, like PRED MILD, should not be used for more than 10 days to reduce the risk of eye and vision problems. If you notice any new eye or vision problems while you are using PRED MILD talk to your healthcare professional immediately.

Other Effects of Corticosteroids

Using corticosteroids, like PRED MILD, can affect how your body handles infections. Infections caused by bacteria, viruses or fungus can be hidden or can get worse when taking PRED MILD. Your body’s ability to fight infection can also be reduced making you more likely to get infections in the eye. If you notice any symptoms of infection, such as eye swelling and redness that is not getting better, eye discharge, fever and chills or you have extreme fatigue talk to your healthcare professional immediately.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

The following may interact with PRED MILD:

• medicines used to treat HIV infection
• antibiotics used to treat bacterial infections such as; clarithromycin, erythromycin
• antifungals used to treat fungal infections such as; ketoconazole, itraconazole, voriconazole, fluconazole
• aprepitant, a medicine used to treat nausea and vomiting
• medicine used to treat high blood pressure and other heart problems such as; diltiazem, verapamil

How to use PRED MILD:

• Always use PRED MILD exactly as your healthcare professional has instructed you. Do not stop using PRED MILD or change your dose without talking to your healthcare professional.
• Shake the bottle well before using.
• Do not use the bottle if the tamper-proof seal on the bottle neck is broken before you first use it.
• To help prevent infections, do not let the tip of the bottle touch your eye or anything else. Put the cap back on and close the bottle immediately after you have used it.

Follow these steps to use PRED MILD properly:

1. 1. Wash your hands. Tilt your head back and look at the ceiling. (See Illustration 1)
2. 2. Gently pull down the lower eyelid to create a small pocket. (See Illustration 2)
3. 3. Turn the bottle upside down and squeeze it gently to release one drop into the eyelid pocket. If a drop misses your eye, try again. (See Illustration 3)
4. 4. Let go of the lower lid and close your eye for 30 seconds. (See Illustration 4)

1. 5. Repeat steps 1 – 4 in the other eye if both eyes need treatment.

Usual adult dose:

Apply 1 to 2 drops in the affected eye(s) two to four times daily.

Overdose:

An overdose of PRED MILD in the eye can be washed out with warm water. Do not use more PRED MILD until it is time for your next dose.

What are possible side effects from using PRED MILD?

These are not all the possible side effects you may feel when taking PRED MILD. If you experience any side effects not listed here, contact your healthcare professional.

Side effects may include:

• headache
• eye irritation, eye pain
• blurred vision
• feeling like there is something in your eye
• large (dilated) pupils
• rash, itching
• change in taste
• slow wound healing

Serious side effects and what to do about them

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

Storage:

PRED MILD should be stored in an upright position, at 15°C to 25°C. Protect from freezing.

Keep out of reach or sight of children.

If you want more information about PRED MILD:

• Talk to your healthcare professional
• Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website ( https://www.canada.ca/en/health-canada.html ); the manufacturer's website www.allergan.ca, or by calling 1-800-668-6424.

Date of Revision: March 14, 2019

All trademarks are the property of their respective owners.

© 2019 Allergan. All rights reserved.

Reporting Side Effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

• Visiting the Web page on Adverse Reaction Reporting ( https://www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada.html ) for information on how to report online, by mail or by fax; or
• Calling toll-free at 1-866-234-2345.

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.