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Redemplo: Uses, Side Effects and Dosage

Status:
Prescription (Rx) Facts
Strength:
25 mg
Active ingredient:

Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - Redemplo

What REDEMPLO is used for:

  • REDEMPLO is used along with diet to help treat a condition called familial chylomicronemia syndrome (FCS) in adults. It is for people whose blood fat levels (called triglycerides) stay high despite other treatments.

How REDEMPLO works:

REDEMPLO belongs to a group of medications called small interfering RNA. It helps lower triglycerides, which are fats in your blood. Keep following a low-fat diet while taking it. If you are also using other medicines to lower fats, keep taking them unless your healthcare professional tells you to stop.

The ingredients in REDEMPLO are:

Medicinal ingredient: plozasiran (as plozasiran sodium)

Non-medicinal ingredients: sodium chloride, water for injection

REDEMPLO comes in the following dosage form(s):

Sterile solution, 25 mg/0.5 mL (50 mg/mL)

Do not use REDEMPLO if:

  • You are allergic to plozasiran or to any other ingredient in REDEMPLO (see “The ingredients in REDEMPLO are”).

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take REDEMPLO. Talk about any health conditions or problems you may have, including if you:

  • You are breastfeeding or plan to breastfeed

  • You are pregnant or plan to become pregnant
  • You have serious kidney disease
  • You have moderate to serious liver disease
  • You have been told that your blood sugar is higher than normal, such as in prediabetes (an early stage where blood sugar is above normal but not yet diabetes) or diabetes.

Other warnings you should know about:

Blood Tests and Monitoring: Before you start taking REDEMPLO, and during treatment, your healthcare professional may order tests to check for side effects. These may include:

  • Blood tests to check:

    • Your blood sugar level – to see how your body handles sugar (glucose)
    • Your blood cholesterol level
    • Your Liver

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements, or alternative medicines.

How to take REDEMPLO:

  • Read the “Instructions For Use” before use, and each time you take the drug.
  • Follow your healthcare professional’s directions. Ask them if you are unsure about anything.

  • Before you use REDEMPLO

    • Keep the medicine in the fridge.
    • Let it sit at room temperature (20°C to 25°C)) for 30 minutes before using.
    • Never use heat (like hot water or a microwave) to warm the syringe.
    • Check the medicine before using. Do NOT use it if it looks cloudy or discolored.

  • Giving the injection

    • You will get this medicine as a shot under the skin (subcutaneous injection).

    • Pick a spot:

      • Outer upper arm (if a caregiver gives it)
      • Thigh
      • Stomach (belly) area.
    • Avoid damaged skin: Do NOT inject into areas that are bruised, red, hard, tender, cut, or have scars or stretch marks.

Usual dose:

You will get this medicine every 3 months

Overdose:

If you think you, or a person you are caring for, have received too much REDEMPLO, contact a healthcare professional, hospital emergency department, regional poison control centre or Health Canada’s toll-free number, 1-844 POISON-X (1-844-764-7669) immediately, even if there are no signs or symptoms.

Missed dose:

If you miss your injection, get it as soon as you can. Then continue getting it every 3 months from that new date.

Possible side effects from using REDEMPLO:

These are not all of the possible side effects you may have when taking REDEMPLO. If you experience any side effects not listed here, tell your healthcare professional.

  • Headache
  • Increase in blood sugar
  • Nausea
  • Pain or bruise at site of injection
  • Runny nose and sore throat
  • Dizziness
  • Itching or hives
  • Palpitations
  • Altered Taste
  • Abdominal pain
  • Constipation

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.

Reporting side effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

  • Visiting the Web page on Adverse Reaction Reporting (canada.ca/drug-device-reporting) for information on how to report online, by mail or by fax; or
  • Calling toll-free at 1-866-234-2345.

NOTE: Contact your healthcare professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

Storing REDEMPLO

  • Storing REDEMPLO prefilled syringe

    • Keep your medication in the fridge (between 2°C and 8°C) in its original box.
    • Once taken out of the fridge, you can keep it at room temperature (20°C to 25°C) for up to 30 days in its original box.
    • After 30 days at room temperature, throw away any unused medication in a sharps container.
    • Always keep the medication out of reach and sight of children.

    • Disposing of Used Syringes

      • After using the syringe, place it and the needle cap in a sharps disposal container right away.
      • Do NOT use any leftover medicine in the used syringe.
      • Never throw the syringe in the regular trash or recycling bin.

If you want more information about REDEMPLO:

  • Talk to your healthcare professional
  • Find the full product monograph that is prepared for healthcare professionals and includes the Patient Medication Information by visiting the Health Canada Drug Product Database website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html); the manufacturer’s website www.redemplo.com; or by calling 1-855-733-6756.

Date of Authorization: 2026-1-02

Instructions For Use

Pr REDEMPLO TM

Plozasiran injection for subcutaneous use

25 mg/0.5 mL

This Instructions for Use contains information on how to inject REDEMPLO (plozasiran).

Guide to Parts

Each carton contains a single-dose REDEMPLO (plozasiran) prefilled syringe for single use under the skin (subcutaneous) injection.

Important Information You Need to Know Before Injecting REDEMPLO

REDEMPLO is for subcutaneous injection only (injected directly under the skin)

Read this Instructions for Use before you start using your REDEMPLO prefilled syringe and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare professional about your medical condition or your treatment.

A healthcare professional who knows how to use the REDEMPLO prefilled syringe should be able to answer your questions. For more information, call 1-855-733-6756 or visit www.redemplo.com.

Storing REDEMPLO prefilled syringe

  • Keep the syringe in its original box at all times.
  • Store it in the fridge between 2°C and 8°C.
  • If needed, you can keep it at room temperature (20°C to 25°C) for up to 30 days — but still in the original box.
  • If the syringe was not stored properly (outside these temperature ranges or time limits), throw it away in a sharps container and use a new one.
  • Always keep the syringe out of reach of children.

Preparing to Inject REDEMPLO

Step 1: Gather all materials needed for your REDEMPLO injection

Figure A

On a clean, well-lit, flat work surface, place (see Figure A):

  • 1 REDEMPLO prefilled syringe in carton

  • Alcohol wipes (not provided)

  • Cotton ball or gauze pad (not provided)
  • Adhesive bandage (not provided)
  • Sharps disposal container (not provided)

Step 2: Prepare to use the REDEMPLO prefilled syringe

Figure B

Figure C

  • If refrigerated, remove the carton from the refrigerator.

  • Open carton lid and remove syringe by the barrel and place on the flat surface (see Figure B).

    • Do not use the prefilled syringe if tamper evident seal on the carton is broken.
    • Do not pick up or pull the prefilled syringe by the plunger rod or gray needle cap.

  • Check the expiration date on the REDEMPLO prefilled syringe (see Figure C).

    • Do not use if the expiration date has passed.

  • Wait 30 minutes for the prefilled syringe to reach room temperature before injecting (see Figure D).

    • Do not try to warm the prefilled syringe by using heat (like hot water or a microwave).

Figure D

  • Do not remove the gray needle cap from the prefilled syringe until you are ready to inject.
Step 3: Check the medicine and syringe

Figure E

Figure F

Check the medicine in the prefilled syringe (see Figure E).

  • The medicine should be clear and colorless to yellow.

    • Do not use the prefilled syringe if the medicine is cloudy, discolored or contains particles.
  • It is normal to see air bubbles in the medicine.

Inspect the prefilled syringe (see Figure F).

  • Do not use the prefilled syringe if any part appears cracked or broken.
  • Do not use the prefilled syringe if the gray needle cap is missing or not securely attached.
  • Do not use the prefilled syringe if it has been dropped onto a hard surface as the syringe may be damaged.

In any of the above cases, call 1-855-733-6756 or visit www.redemplo.com.

Injecting REDEMPLO

Step 4: Choose your injection site

Figure G

Where to Inject (see Figure G):

  • You can inject into:

    • your thigh
    • your stomach (belly) — but avoid the 2-inch area around your belly button
  • Only your healthcare providers or caregivers can inject into the outer part of your upper arm (see Figure G).

Areas to Avoid

  • Do not inject into skin that is tender, bruised, red, hard, cut
  • Avoid areas with scars or stretch marks

Step 5: Wash hands and clean the injection site

Figure H

  • Wash your hands thoroughly with soap and water (see Figure H).

  • Clean your injection site with an alcohol wipe. Let your skin dry before injecting (see Figure I).

    • Do not touch the cleaned skin before injecting.

Figure I

Step 6: Remove the needle cap
Figure J
  • Hold the prefilled syringe by the syringe barrel, with the needle facing away from you.

  • Pull the gray needle cap straight up and away from your body (see Figure J).

    • Do not twist or bend the gray needle cap.

  • Avoid pushing the plunger head before you are ready to inject.

    • Do not let the needle touch any surface.
    • Do not put the needle cap back onto the syringe.
Step 7: Pinch the skin and Insert the needle
Figure K
  • Hold your prefilled syringe by the finger flange in one hand.
  • Gently pinch and hold a fold of skin at injection site with your other hand.
  • Insert needle at 45°(degree) to 90° angle (see Figure K).

  • Keep the skin pinched while inserting the needle and during injection.

    • Do not place your finger on the plunger head before the injection.
Step 8: Hold skin pinch and Push down the plunger head

Figure L

  • While pinching the skin, push the plunger head all the way down using slow and constant pressure (see Figure L).
Step 9: Complete the Injection

Figure M

  • After the plunger is pushed all the way down, take the needle out of the skin by gently lifting the syringe up and off the skin until the needle is completely removed (see Figure M).

    • Do not pull the plunger head up. Lift the whole syringe straight up.
    • Do not rub the injection site.

  • There may be a small amount of blood or liquid where you inject. This is normal.

    • If needed, press a cotton ball or gauze pad on the area and apply an adhesive bandage.

  • Place the used cap and syringe in a sharps disposal container right away. (See section – “Disposing of REDEMPLO”).

    • Do not put the needle cap back onto the syringe.
Disposing of REDEMPLO

Figure N

  • Do not use any leftover medicine in a used syringe.

  • Right after use, place the syringe and needle cap into a sharps disposal container.

    • Do not put the needle cap back onto the syringe.

  • Never throw the syringe in your household trash or recycling bin (see Figure J). If you do not have a Sharps Container, you can use a household container that meets these safety rules:

    • made of heavy-duty plastic
    • has a strong, protective lid that prevents needles from poking through
    • is upright and stable during use
    • is leak-resistant
    • is clearly labeled to warn of hazardous waste inside

  • When the container Is almost full

    • Follow your local or provincial guidelines for proper disposal.
    • Do not throw away the sharps container in household trash unless your community allows it.
    • Do not recycle your sharps container.

For more help, contact your local pharmacy or healthcare professional

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02564327

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Redemplo

Rx or OTC
Prescription (Rx)?
DIN 02564327
Schedule(s) PRESCRIPTION
Active ingredient(s) Plozasiran (plozasiran sodium) 25 MG
Dosage form(s) Solution
Route(s) of administration Subcutaneous
Company ARROWHEAD PHARMACEUTICALS, INC.
Current status Marketed
Current status date July 2, 2026

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.