Patient Medication Information: uses, side effects, how to take - Waymade-Trientine
What is WAYMADE-TRIENTINE used for?
- WAYMADE-TRIENTINE is used for the treatment of Wilson’s disease. It is used in adult patients who cannot take the drug penicillamine.
How does WAYMADE-TRIENTINE work?
WAYMADE-TRIENTINE works by attaching to the copper, and then passing it from your body. WAYMADE-TRIENTINE may also work by attaching to the copper in your stomach and stopping it from being absorbed.
What are the ingredients in WAYMADE-TRIENTINE?
Medicinal ingredients: trientine hydrochloride
Non-medicinal ingredients: black ink, gelatin, purified water, stearic acid, sunset yellow FCF, titanium dioxide
WAYMADE-TRIENTINE comes in the following dosage forms:
WAYMADE-TRIENTINE is available as 250 mg capsules.
Serious Warnings and Precautions
WAYMADE-TRIENTINE will only be given to you under the care of a healthcare professional who is experienced in the treatment of Wilson’s disease. Starting treatment with WAYMADE-TRIENTINE may result in permanent worsening of your existing nervous system problems. If you experience any worsening of the following symptoms while taking WAYMADE-TRIENTINE, stop taking the drug and get immediate medical help:
Your healthcare professional will monitor your response for these symptoms for the first few months when you start taking WAYMADE-TRIENTINE. |
Do not use WAYMADE-TRIENTINE if:
- You are allergic to trientine hydrochloride or any of the other ingredients in this drug or the container.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take WAYMADE-TRIENTINE. Talk about any health conditions or problems you may have, including if you:
- have breathing problems such as asthma or bronchitis (swelling of the bronchial tubes, the airways that carry air to your lungs).
- have dermatitis (red and itchy dry skin)
- have anemia (low iron in your blood)
are pregnant, think you are pregnant, or plan to become pregnant
- are breast feeding
- are older than 65 years of age.
Other warnings you should know about:
Monitoring and Testing
Your healthcare professional will order lab tests for you during your treatment. This will help determine copper levels in your body and how your body responds to the treatment with WAYMADE-TRIENTINE.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with WAYMADE-TRIENTINE:
- Mineral and iron supplements
How to take WAYMADE-TRIENTINE:
- Take WAYMADE-TRIENTINE exactly as your healthcare professional tells you. Your healthcare professional will determine the right dose for you.
Take WAYMADE-TRIENTINE on an empty stomach, at least 1 hour before meals or 2 hours after meals.
- Take WAYMADE-TRIENTINE at least 1 hour apart from any other drug, food, or milk.
- Your healthcare professional may give you an iron supplement if needed. Take the iron at least 2 hours apart from WAYMADE-TRIENTINE.
- Swallow the capsules whole with water, and do not open or chew the capsules.
- Touching the contents of the WAYMADE-TRIENTINE capsules may cause your skin to become red and itchy. Wash your hands with water if you accidentally touch the contents of the WAYMADE-TRIENTINE capsules.
Usual dose:
Adults: the starting dose is 3 capsules (750 mg) per day, given in divided doses 2 – 4 times a day. The maximum dose is 8 capsules (2,000 mg) per day.
Children and Adolescents (5 – 17 years old): the starting dose is 2 capsules per day (500 mg / day) given in divided doses 2 – 4 times a day. The maximum dose is 6 capsules a day (1,500 mg / day) for patients 12 years old or under.
Overdose:
| If you think you, or a person you are caring for, have taken too much WAYMADE-TRIENTINE, contact a healthcare professional, hospital emergency department, or regional poison control centre immediately, even if there are no symptoms. |
|---|
Missed Dose:
If you missed a dose of WAYMADE-TRIENTINE, take it as soon as you remember. But if it is almost time for your next dose, skip the missed dose and continue with your next scheduled dose. Go back to the regular dosing schedule. Do not take two doses at the same time or very close to each other.
What are possible side effects from using WAYMADE-TRIENTINE?
These are not all the possible side effects you may have when taking WAYMADE-TRIENTINE. If you experience any side effects not listed here, tell your healthcare professional.
Symptoms may include:
- Nausea
- Rash, itchy or red skin
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
|---|---|---|---|
| Only if severe | In all cases | ||
| UNCOMMON | |||
| Duodenitis and/or colitis (bowel inflammation): nausea, fatigue, vomiting, diarrhea, bloating, abdominal pain, fever | √ | ||
| RARE | |||
| Anemia (low levels of red blood cells): pale skin, feeling tired or weak, shortness of breath, irregular heartbeat | √ | ||
| UNKNOWN | |||
| Asthma, bronchitis (lung or airway problems): difficulty breathing and coughing, shortness of breath, chest tightness, wheezing or whistling sound when breathing, fever, runny nose | √ | ||
| Neurological deterioration (nervous system problems): | √ | ||
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help |
|---|---|---|
| Only if severe | In all cases | |
symptoms include:
| ||
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, tell your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
- Store WAYMADE-TRIENTINE at 2° to 8°C. Keep refrigerated. Do not freeze.
- After the first opening, the bottle can be stored at room temperature for 2 months.. Dispose after 2 months.
- Store the capsules in their original bottle. Keep the bottle tightly closed and leave the silica gel sachet in the bottle to protect from humidity.
- Keep out of reach and sight of children.
If you want more information about WAYMADE-TRIENTINE:
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website: (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/drug-product-database.html; the manufacturer’s website (www.waymade.co.uk), or by calling 1-800-970-8841.