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Clinimix E (Baxter, 10 G / 263 mg / 263 mg / 246 mg / 246..., ..., 25 G / 365 mg / 280 mg / 290 mg / 200...): Uses, Side Effects and Dosage

Updated:
Facts
Status:
Current status: Cancelled Post Market
Strength:
10 g / 263 mg / 263 mg / 246 mg / 246 mg / 880 mg / 880 mg / 440 mg / 203 mg / 195 mg / 186 mg / 178 mg / 76 mg / 178 mg / 17 mg / 297 mg / 261 mg / 77 mg / 51 mg, 25 g / 310 mg / 310 mg / 290 mg / 290 mg / 1.04 g / 1.04 g / 520 mg / 240 mg / 230 mg / 220 mg / 210 mg / 90 mg / 210 mg / 20 mg, 25 g / 310 mg / 310 mg / 290 mg / 290 mg / 1.04 g / 1.04 g / 520 mg / 240 mg / 230 mg / 220 mg / 210 mg / 90 mg / 210 mg / 20 mg / 340 mg / 261 mg / 58.5 mg / 51 mg, 25 g / 263 mg / 263 mg / 246 mg / 246 mg / 880 mg / 880 mg / 440 mg / 203 mg / 195 mg / 186 mg / 178 mg / 76 mg / 178 mg / 17 mg, 25 g / 263 mg / 263 mg / 246 mg / 246 mg / 880 mg / 880 mg / 440 mg / 203 mg / 195 mg / 186 mg / 178 mg / 76 mg / 178 mg / 17 mg / 297 mg / 261 mg / 77 mg / 51 mg, 10 g / 263 mg / 263 mg / 246 mg / 246 mg / 880 mg / 880 mg / 440 mg / 203 mg / 195 mg / 186 mg / 178 mg / 76 mg / 178 mg / 17 mg, 25 g / 365 mg / 280 mg / 290 mg / 200 mg / 300 mg / 290 mg / 240 mg / 210 mg / 90 mg / 1.04 g / 575 mg / 340 mg / 250 mg / 515 mg / 20 mg / 340 mg / 261 mg / 58.5 mg / 51 mg
Active ingredients:
ATC code:
Similar drugs:

Source: Health Canada – Drug Product Database (DPD) and product monographs · About this document

Patient Medication Information: uses, side effects, how to take - Clinimix E (Baxter, 10 G / 263 mg / 263 mg / 246 mg / 246..., ..., 25 G / 365 mg / 280 mg / 290 mg / 200...)

ABOUT THIS MEDICATION

What the medication is used for:

CLINIMIX E (amino acids with electrolytes in dextrose injection) and CLINIMIX (amino acids without electrolytes in dextrose injection) are intravenous nutritive supplements used to provide nutrition through a tube into a vein when normal feeding by mouth is not possible or suitable.

CLINIMIX E / CLINIMIX products must only be used under medical supervision.

What it does:

The use of CLINIMIX E / CLINIMIX products is a way to ensure that patients who are unable to eat get an adequate intake of energy, nitrogen and other nutrients, and helps to treat or prevent malnutrition.

When it should not be used:

CLINIMIX E and CLINIMIX products should not be used if:

  • You are allergic to any ingredients (See What the medicinal ingredients are and What the nonmedicinal ingredients are).
  • Your body has problems processing certain amino acids and these amino acids are included in CLINIMIX E / CLINIMIX products.
  • You are being administered ceftriaxone.
  • You have high plasma concentrations of one of the electrolytes included in CLINIMIX E.
  • You have liver failure or coma resulting from liver failure.
  • You have kidney failure and are not on dialysis.

  • You have hyperglycemia (too much sugar in your blood), which is not controlled.

    • You have an allergy to corn or corn products since this product contains dextrose from corn.

Also, CLINIMIX E products should not be used if:

  • You have a disorder resulting in high blood levels of substances such as potassium (hyperkalemia), calcium (hypercalcemia), phosphorus (hyperphosphatemia), sodium (hypernatremia) and magnesium (hypermagnesemia).
  • You are receiving calcium-containing intravenous solutions.

What the medicinal ingredients are:

CLINIMIX E products and CLINIMIX products are solutions for infusion, each supplied in a bag with two chambers:

  • one chamber contains a dextrose solution

  • one chamber contains a solution of an amino acids:

    Amino acid chamber in CLINIMIX (Blend B) contains: L-alanine, L-arginine, Glycine, L-histidine, L-isoleucine, L-leucine, L-lysine hydrochloride, L-methionine, L-phenylalanine, L-proline, L-threonine, L-tryptophan, L-tyrosine, L-valine

    Amino acid chamber in CLINIMIX E (Blend B) contains: all amino acids listed under CLINIMIX (Blend B) plus electrolytes in the form of sodium chloride, sodium acetate trihydrate, bibasic potassium phosphate and magnesium chloride hexahydrate

    Amino acid chamber in CLINIMIX (Blend C) contains: all amino acids listed under CLINIMIX (Blend B) plus L-Serine

    Amino acid chamber in CLINIMIX E (Blend C) contains: all amino acids listed under CLINIMIX (Blend C) plus electrolytes in the form of sodium chloride, sodium acetate trihydrate, bibasic potassium phosphate and magnesium chloride hexahydrate

What the nonmedicinal ingredients are:

Glacial acetic acid (for pH adjustment), Nitrogen and Water for injection.

What dosage forms it comes in:

CLINIMIX E / CLINIMIX products are solutions for infusion (into the veins). It is supplied in a bag with two chambers. The chambers are separated by a non-permanent seal. Just before administration, the contents of the two chambers are mixed together by rolling the top of the bag to open the seals.

The mixed solution for each of the different strengths provides a different amount of amino acids, dextrose, and, with some formulations, electrolytes so that your healthcare professional can tailor the infusion to your particular needs.

WARNINGS AND PRECAUTIONS

BEFORE you use CLINIMIX E (amino acids with electrolytes in dextrose injection) or CLINIMIX (amino acids without electrolytes in dextrose injection), talk to your healthcare professional if:

  • You are allergic to any ingredients. (See What the medicinal ingredients are and What the nonmedicinal ingredients are).
  • You suffer from metabolic acidosis (when the blood is excessively acid)
  • You have kidney or liver problems
  • You are taking any other medicines on a regular basis.

  • You are pregnant or intend to become pregnant

  • You are breastfeeding or intend to breastfeed
  • You have pulmonary edema (collection of fluid into the lung tissue)
  • You have heart failure
  • You have fluid overload (too much water in your body)
  • You are diabetic
  • You have hereditary fructose intolerance as this product may contain small amounts of fructose.

In all cases, your healthcare professional will base his/her decision to treat you or your child on factors such as age, weight and clinical condition, together with the results of any tests. Always be sure to check with your healthcare professional if anything about your condition changes.

In newborns and infants, your healthcare professional will measure blood ammonia frequently to check for the presence of a congenital abnormality of amino acid metabolism.

If you develop breathing problems during CLINIMIX E / CLINIMIX treatment, contact you doctor immediately.

Your healthcare professional will need to monitor how you are doing while you are on this intravenous nutritive supplement. This means that you will need to have laboratory tests done on a routine basis.

INTERACTIONS WITH THIS MEDICATION

No drug interaction studies have been done with CLINIMIX E (amino acids with electrolytes in dextrose injection) or CLINIMIX (amino acids without electrolytes in dextrose injection).

CLINIMIX E / CLINIMIX products must NOT be administered simultaneously with blood through the same infusion tubing.

Let your healthcare professional know if you are receiving corticosteroids or corticotropin.

There may be interactions between the nutrients in CLINIMIX E / CLINIMIX products and one or more of your medications, for example diuretics, blood pressure drugs, or drugs used to suppress your immune system. You should review your medications with your healthcare professional.

PROPER USE OF THIS MEDICATION

Usual dose:

Your healthcare professional will select the best CLINIMIX E (amino acids with electrolytes in dextrose injection) or CLINIMIX (amino acids without electrolytes in dextrose injection) product for you, based on your age and body weight. Your healthcare professional will ensure that you are getting sufficient calories so that the amino acids from TRAVASOL E (amino acids with electrolytes injection) and TRAVASOL (amino acids without electrolytes injection) will be absorbed. Your healthcare professional will also specify a flow rate corresponding to your needs and medical condition.

Overdose:

If your dose is too high or is infused too quickly, the amino acid content may make your blood too acid, or the dextrose content may increase the glucose in your blood and urine. Giving too high a volume may cause fluid overload.

To prevent these events occurring, your healthcare professional will regularly monitor your condition and test your blood and urine parameters.

In case you feel you have been administered too much CLINIMIX E / CLINIMIX products, contact your healthcare practitioner (e.g. healthcare professional), hospital emergency
department or the regional poison control centre, even if there are no symptoms.

Missed Dose:

If you feel a dose has been missed contact your attending healthcare professional.

SIDE EFFECTS AND WHAT TO DO ABOUT THEM

If you notice any changes in the way you feel during or after the treatment, tell your healthcare professional or another member of your medical team immediately.

The tests your healthcare professional will perform while you are taking the intravenous nutritive supplement should reduce the risk of side effects.

If any symptoms of an allergic reaction develop, such as fever or chills, shivering, skin rashes, severe headache or breathing difficulties, contact your attending healthcare professional immediately.

Other side effects may include rapid heart beat, sweating, nausea, and vomiting.

If any side effect gets serious, or if you notice any side effect not listed in this leaflet, please tell your healthcare professional or a member of your medical team right away.

Occasional reddening and stinging may occur at the point where the tubing enters the body. If this occurs, tell your healthcare professional or nurse immediately.

SERIOUS SIDE EFFECTS, HOW OFTEN THEY HAPPEN AND WHAT TO DO ABOUT THEM
Symptom / effectTalk with your healthcare professionalStop the infusion and contact your doctor (or healthcare professional)
Only if severeIn all cases
Uncommon
Allergic reactions with symptoms such as fever or chills, shivering, skin rashes, breathing difficulties, severe headache
√

This is not a complete list of side effects. For any unexpected effects while taking CLINIMIX E (amino acids with electrolytes in dextrose injection) and CLINIMIX (amino acids without electrolytes in dextrose injection), contact your healthcare professional.

HOW TO STORE IT

The heatlhcare professional will store the CLINIMIX E / CLNIMIX product at temperatures between 15°C and 25°C, protected from light and kept from freezing.

Once the seals between the chambers have been broken and the product has been mixed, it should be administered to you immediately.

REPORTING SUSPECTED SIDE EFFECTS

You can report any suspected adverse reactions associated with the use of health products to the Canada Vigilance Program by one of the following 3 ways:

  • Report online at www.healthcanada.gc.ca/medeffect
  • Call toll-free at 1-866-234-2345

  • Complete a Canada Vigilance Reporting Form and:

    • Fax toll-free to 1-866-678-6789, or

    • Mail to: Canada Vigilance Program

      Health Canada

      Postal Locator 0701E

      Ottawa, Ontario K1A 0K9

Postage paid labels, Canada Vigilance Reporting Form and the adverse reaction reporting guidelines are available on the MedEffect™ Canada Web site at www.healthcanada.gc.ca/medeffect.

NOTE: Should you require information related to the management of side effects, contact your health professional. The Canada Vigilance Program does not provide medical advice.

MORE INFORMATION

This document plus the full product monograph, prepared for health professionals can be obtained by contacting the sponsor, Baxter Corporation, at 1-888-719-9955.

Baxter, Clinimix, Clarity and Travasol are registered trademarks of Baxter International Inc.

Last revised: April 30, 2015

About this document

Source: Health Canada – Drug Product Database (DPD) and product monographs · DIN (Drug Identification Number): 02014025

Revision date stated in the text: April 30, 2015

Found a mistake? Write to us via the contact page.

The information on this site does not replace the advice of a doctor or pharmacist.

Drug information for Clinimix E (Baxter, 10 G / 263 mg / 263 mg / 246 mg / 246..., ..., 25 G / 365 mg / 280 mg / 290 mg / 200...)

DIN 02014025, 02013959, 02014084, 02013916, 02014041, 02013924, 02142341
Schedule(s) ETHICAL
Active ingredient(s) Dextrose, L-leucine hydrochloride, L-phenylalanine hydrochloride, L-lysine hydrochloride, Methionine, L-alanine, Glycine, L-arginine, L-isoleucine, L-valine, Histidine, L-threonine, Tryptophan, L-proline, L-tyrosine, Sodium acetate, Potassium phosphate dibasic, Sodium chloride, Magnesium chloride
Dosage form(s) Solution
Route(s) of administration Intravenous
Drug class (WHO ATC)
  1. B Blood and blood forming organ drugs
    1. B05 Blood substitutes and perfusion solutions
      1. B05B IV solutions used in parenteral administration of fluids, electrolytes and nutrients
        1. B05BA Solutions for parenteral nutrition
          1. B05BA10 Combinations
Company BAXTER CORPORATION
Current status Cancelled Post Market
Strengths and forms
DIN Strength Dosage form(s) Current status
02014025 10 G / 263 MG / 263 MG / 246 MG / 246 MG / 880 MG / 880 MG / 440 MG / 203 MG / 195 MG / 186 MG / 178 MG / 76 MG / 178 MG / 17 MG / 297 MG / 261 MG / 77 MG / 51 MG Solution Cancelled Post Market June 28, 2018
02013959 25 G / 310 MG / 310 MG / 290 MG / 290 MG / 1.04 G / 1.04 G / 520 MG / 240 MG / 230 MG / 220 MG / 210 MG / 90 MG / 210 MG / 20 MG Solution Cancelled Post Market June 28, 2018
02014084 25 G / 310 MG / 310 MG / 290 MG / 290 MG / 1.04 G / 1.04 G / 520 MG / 240 MG / 230 MG / 220 MG / 210 MG / 90 MG / 210 MG / 20 MG / 340 MG / 261 MG / 58.5 MG / 51 MG Solution Cancelled Post Market July 15, 2016
02013916 25 G / 263 MG / 263 MG / 246 MG / 246 MG / 880 MG / 880 MG / 440 MG / 203 MG / 195 MG / 186 MG / 178 MG / 76 MG / 178 MG / 17 MG Solution Cancelled Post Market July 15, 2016
02014041 25 G / 263 MG / 263 MG / 246 MG / 246 MG / 880 MG / 880 MG / 440 MG / 203 MG / 195 MG / 186 MG / 178 MG / 76 MG / 178 MG / 17 MG / 297 MG / 261 MG / 77 MG / 51 MG Solution Cancelled Post Market June 28, 2018
02013924 10 G / 263 MG / 263 MG / 246 MG / 246 MG / 880 MG / 880 MG / 440 MG / 203 MG / 195 MG / 186 MG / 178 MG / 76 MG / 178 MG / 17 MG Solution Cancelled Post Market July 15, 2016
02142341 25 G / 365 MG / 280 MG / 290 MG / 200 MG / 300 MG / 290 MG / 240 MG / 210 MG / 90 MG / 1.04 G / 575 MG / 340 MG / 250 MG / 515 MG / 20 MG / 340 MG / 261 MG / 58.5 MG / 51 MG Solution Cancelled Post Market June 28, 2018

Source: Health Canada – Drug Product Database (DPD) and product monographs, data as of November 1, 2026. Data from the Health Canada Drug Product Database, as published there. Not a substitute for the advice of a doctor or pharmacist.