Patient Medication Information: uses, side effects, how to take - 20% Prosol
What is 20% ProSol used for?
20% ProSol is given to you with other products that contain a source of energy as a source of amino acids. These are nutrients your body needs to make proteins. 20% ProSol is given to you where:
(1) You cannot or should not eat normally.
(2) Your stomach cannot absorb amino acids properly, or
(3) Your body needs more proteins than usual. An example is when you have extensive burns.
How does 20% ProSol work?
20% ProSol is given to you with other products through an infusion into your vein. It contains amino acids, which are used by your body to make proteins.
What are the ingredients in 20% ProSol?
Medicinal ingredients:
| Ingredients (g) | Per 100mL |
Essential Amino Acids L-Valine L-Histidine L-Isoleucine L-Leucine L-Phenylalanine L-Threonine L-Lysine L-Methionine L-Tryptophan Non-Essential Amino Acids L-Alanine Glycine L-Arginine L-Proline L-Glutamic Acid L-Serine L-Aspartic Acid L-Tyrosine | 1.44 g 1.18 g 1.08 g 1.08 g 1.00 g 0.980 g 0.957 g 0.760 g 0.320 g 2.76 g 2.06 g 1.96 g 1.34 g 1.02 g 1.02 g 0.600 g 0.050 g |
Non-medicinal ingredients: Glacial acetic acid (for pH adjustment), and water for injection.
20% ProSol comes in the following dosage forms:
Solution for infusion supplied in bags, 20% w/v amino acids.
Do not use 20% ProSol if:
- You are allergic to any of the ingredients in 20% ProSol or components of the container. (See What are the ingredients in 20% ProSol).
- Your body has problems processing certain amino acids and these amino acids are included in this 20% ProSol product.
- You have liver failure or coma resulting from liver failure.
- You have kidney failure and you are not currently getting any treatment for it.
To help avoid side effects and ensure proper use, talk to your healthcare professional before you take 20% ProSol. Talk about any health conditions or problems you may have, including if you:
- You suffer from metabolic acidosis (when the blood is very acidic).
- Have diabetes.
- Have problems with your metabolism.
- You have kidney problems.
- You have liver problems.
- You are taking calcium-containing intravenous solutions.
You are pregnant or intend to become pregnant.
- You are breastfeeding or intend to breastfeed.
- You have pulmonary edema (collection of fluid into the lung tissue).
- You have heart failure.
- You have fluid overload (too much water in your body) or problems with water and electrolytes.
Other warnings you should know about:
In all cases, your healthcare professional will base their decision to treat you or your child on factors such as age, weight and clinical condition, together with the results of any tests. Always check with your healthcare professional if anything about your condition changes.
20% ProSol can cause serious allergic reactions. Tell your healthcare professional right away if you have symptoms such as difficulty swallowing or breathing, fever, headache, shivering, skin rash or hives, shortness of breath, swelling of the face, lips, tongue or throat.
In newborns and infants, your healthcare professional will measure blood ammonia often to check for a condition called “congenital abnormality of amino acid metabolism.” This is a condition from birth where your child cannot metabolize amino acids properly.
Your healthcare professional will need to monitor how you are doing while you are on 20% ProSol. This means that you will need to have laboratory tests done on a routine basis.
Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
The following may interact with 20% ProSol:
- corticosteroids or corticotropin.
- tetracycline.
- medicines or infusions containing calcium.
How to take 20% ProSol:
- 20% ProSol will be given to you by a healthcare professional.
- Your healthcare professional will make sure that 20% ProSol is prepared correctly before it is given to you.
- 20% ProSol will be infused into your vein.
- 20% ProSol will be given to you with other with other products that contain a source of energy.
Usual dose:
- Your healthcare professional will decide about the amount of 20% ProSol you should receive based on your age, bodyweight, and medical condition.
Overdose:
If your dose is too high or is infused too quickly, the amino acid content may make your blood too acidic. Giving too high a volume may cause fluid overload. This may cause severe side effects or death.
To prevent these events occurring, your healthcare professional will regularly monitor your condition and test your blood and urine levels.
| In case you feel you have been administered too much 20% ProSol product, contact your healthcare practitioner (e.g. healthcare professional), hospital emergency department or the regional poison control centre, even if there are no symptoms. |
Missed Dose:
If you feel a dose has been missed, contact your attending healthcare professional.
What are possible side effects from using 20% ProSol?
These are not all the possible side effects you may feel when taking 20% ProSol. If you experience any side effects not listed here, contact your healthcare professional.
If you notice any changes in the way you feel during or after the treatment, tell your healthcare professional or another member of your medical team immediately.
Side effects may include:
- rapid heart beat
- sweating
- nausea
- vomiting
- stomach swelling
- pain on the right side of your stomach area (liver)
- muscle and joint pain
Serious side effects and what to do about them
| Symptom / effect | Talk to your healthcare professional | Stop taking drug and get immediate medical help | |
| Only if severe | In all cases | ||
| UNCOMMON* | |||
Allergic reaction: difficulty swallowing or breathing, fever, headache, shivering, skin rash or hives, shortness of breath, swelling of the face, lips, tongue or throat. | √ | ||
| Hyperammonemia (high ammonia levels in the blood): headache, vomiting, confusion, irritability | √ | ||
| Azotemia (high nitrogen levels in the body): fatigue, fever, chills, nausea, swelling of feet or ankles, dark or red-coloured urine, change in how often you urinate | √ | ||
| Pulmonary vascular precipitates (a condition where solids from the solution form in the lungs): chest pain, cough, shortness of breath | √ | ||
| Liver Problems: yellow colour to skin, whites of the eyes (jaundice), Abdominal pain, itching, fatigue, fever, confusion, sleepiness | √ | ||
| Infusion site reaction: redness, pain, swelling, and stinging at the point where the tubing enters the body for infusion. | √ | ||
* Side effects that have been reported with injectable nutrition products.
If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice. |
Storage:
The heatlhcare professional will store 20% ProSol at temperatures between 15°C and 25°C, protected from light, excessive heat, and freezing.
Keep out of reach and sight of children.
If you want more information about 20% ProSol:
- Talk to your healthcare professional
- Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada/services/drugs-health-products/drug- products/drug-product-database.html); the manufacturer’s website www.baxter.ca, or by calling 1-800-719-9955.
Baxter, ProSol and Viaflex are registered trademarks of Baxter International Inc.